Rationale and design of the long-Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients (TIGRIS) study
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Rationale and design of the long-Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients (TIGRIS) study. / Westermann, Dirk; Goodman, Shaun G; Nicolau, José C; Requena, Gema; Maguire, Andrew; Chen, Ji Yan; Granger, Christopher B; Grieve, Richard; Pocock, Stuart J; Blankenberg, Stefan; Vega, Ana Maria; Yasuda, Satoshi; Simon, Tabassome; Brieger, David; TIGRIS Study Investigators.
In: CLIN CARDIOL, Vol. 40, No. 12, 12.2017, p. 1197-1204.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Rationale and design of the long-Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients (TIGRIS) study
AU - Westermann, Dirk
AU - Goodman, Shaun G
AU - Nicolau, José C
AU - Requena, Gema
AU - Maguire, Andrew
AU - Chen, Ji Yan
AU - Granger, Christopher B
AU - Grieve, Richard
AU - Pocock, Stuart J
AU - Blankenberg, Stefan
AU - Vega, Ana Maria
AU - Yasuda, Satoshi
AU - Simon, Tabassome
AU - Brieger, David
AU - TIGRIS Study Investigators
N1 - © 2017 Wiley Periodicals, Inc.
PY - 2017/12
Y1 - 2017/12
N2 - The long-term progression of coronary artery disease as defined by the natural disease course years after a myocardial infarction (MI) is an important but poorly studied area of clinical research. The long-Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients (TIGRIS) study was designed to address this knowledge gap by evaluating patient management and clinical outcomes following MI in different regions worldwide. TIGRIS (ClinicalTrials.gov Identifier: NCT01866904) is a multicenter, observational, prospective, longitudinal study enrolling patients with history of MI 1 to 3 years previously and high risk of developing atherothrombotic events in a general-practice setting. The primary objective of TIGRIS is to evaluate clinical events (time to first occurrence of any event from the composite cardiovascular endpoint of MI, unstable angina with urgent revascularization, stroke, or death from any cause), and healthcare resource utilization associated with hospitalization for these events (hospitalization duration and procedures) during follow-up. Overall, 9225 patients were enrolled between June 2013 and November 2014 and are being followed in 369 different centers worldwide. This will allow for the description of regional differences in patient characteristics, risk profiles, medical treatment patterns, clinical outcomes, and healthcare resource utilization. Patients will be followed for up to 3 years. Here we report the rationale, design, patient distribution, and selected baseline characteristics of the TIGRIS study. TIGRIS will describe real-world management, quality of life (self-reported health), and healthcare resource utilization for patients with stable coronary artery disease ≥1 year post-MI.
AB - The long-term progression of coronary artery disease as defined by the natural disease course years after a myocardial infarction (MI) is an important but poorly studied area of clinical research. The long-Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients (TIGRIS) study was designed to address this knowledge gap by evaluating patient management and clinical outcomes following MI in different regions worldwide. TIGRIS (ClinicalTrials.gov Identifier: NCT01866904) is a multicenter, observational, prospective, longitudinal study enrolling patients with history of MI 1 to 3 years previously and high risk of developing atherothrombotic events in a general-practice setting. The primary objective of TIGRIS is to evaluate clinical events (time to first occurrence of any event from the composite cardiovascular endpoint of MI, unstable angina with urgent revascularization, stroke, or death from any cause), and healthcare resource utilization associated with hospitalization for these events (hospitalization duration and procedures) during follow-up. Overall, 9225 patients were enrolled between June 2013 and November 2014 and are being followed in 369 different centers worldwide. This will allow for the description of regional differences in patient characteristics, risk profiles, medical treatment patterns, clinical outcomes, and healthcare resource utilization. Patients will be followed for up to 3 years. Here we report the rationale, design, patient distribution, and selected baseline characteristics of the TIGRIS study. TIGRIS will describe real-world management, quality of life (self-reported health), and healthcare resource utilization for patients with stable coronary artery disease ≥1 year post-MI.
KW - Aged
KW - Coronary Artery Disease/epidemiology
KW - Disease Management
KW - Disease Progression
KW - Female
KW - Follow-Up Studies
KW - Global Health
KW - Humans
KW - Male
KW - Morbidity/trends
KW - Myocardial Infarction/complications
KW - Patient Acceptance of Health Care/statistics & numerical data
KW - Prognosis
KW - Prospective Studies
KW - Quality of Life
KW - Risk Assessment
KW - Risk Factors
KW - Time Factors
U2 - 10.1002/clc.22837
DO - 10.1002/clc.22837
M3 - SCORING: Journal article
C2 - 29247524
VL - 40
SP - 1197
EP - 1204
JO - CLIN CARDIOL
JF - CLIN CARDIOL
SN - 0160-9289
IS - 12
ER -