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Rates of metastatic prostate cancer in newly diagnosed patients: Numbers needed to image according to risk level

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Rates of metastatic prostate cancer in newly diagnosed patients: Numbers needed to image according to risk level. / Sorce, Gabriele; Hoeh, Benedikt; Flammia, Rocco S; Chierigo, Francesco; Hohenhorst, Lukas; Panunzio, Andrea; Nimer, Nancy; Tian, Zhe; Gandaglia, Giorgio; Tilki, Derya; Terrone, Carlo; Gallucci, Michele; Chun, Felix K H; Antonelli, Alessandro; Saad, Fred; Shariat, Shahrokh F; Montorsi, Francesco; Briganti, Alberto; Karakiewicz, Pierre I.

In: PROSTATE, Vol. 82, No. 12, 09.2022, p. 1210-1218.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sorce, G, Hoeh, B, Flammia, RS, Chierigo, F, Hohenhorst, L, Panunzio, A, Nimer, N, Tian, Z, Gandaglia, G, Tilki, D, Terrone, C, Gallucci, M, Chun, FKH, Antonelli, A, Saad, F, Shariat, SF, Montorsi, F, Briganti, A & Karakiewicz, PI 2022, 'Rates of metastatic prostate cancer in newly diagnosed patients: Numbers needed to image according to risk level', PROSTATE, vol. 82, no. 12, pp. 1210-1218. https://doi.org/10.1002/pros.24376

APA

Sorce, G., Hoeh, B., Flammia, R. S., Chierigo, F., Hohenhorst, L., Panunzio, A., Nimer, N., Tian, Z., Gandaglia, G., Tilki, D., Terrone, C., Gallucci, M., Chun, F. K. H., Antonelli, A., Saad, F., Shariat, S. F., Montorsi, F., Briganti, A., & Karakiewicz, P. I. (2022). Rates of metastatic prostate cancer in newly diagnosed patients: Numbers needed to image according to risk level. PROSTATE, 82(12), 1210-1218. https://doi.org/10.1002/pros.24376

Vancouver

Sorce G, Hoeh B, Flammia RS, Chierigo F, Hohenhorst L, Panunzio A et al. Rates of metastatic prostate cancer in newly diagnosed patients: Numbers needed to image according to risk level. PROSTATE. 2022 Sep;82(12):1210-1218. https://doi.org/10.1002/pros.24376

Bibtex

@article{f4402872f3a64b87b3708cb03f52d83d,
title = "Rates of metastatic prostate cancer in newly diagnosed patients: Numbers needed to image according to risk level",
abstract = "BACKGROUND: The numbers needed to image to identify pelvic lymph node and/or distant metastases in newly diagnosed prostate cancer (PCa) patients according to risk level are unknown.METHODS: Relying on Surveillance, Epidemiology, and End Results (2010-2016), we tabulated rates and proportions of patients with (a) lymph node or (b) distant metastases according to National Comprehensive Cancer Network (NCCN) risk level and calculated the number needed to image (NNI) for both endpoints. Multivariable logistic regression analyses were performed.RESULTS: Of 145,939 newly diagnosed PCa patients assessable for analyses of pelvic lymph node metastases (cN1), 4559 (3.1%) harbored cN1 stage: 13 (0.02%), 18 (0.08%), 63 (0.3%), 512 (2.8%), and 3954 (14.9%) in low, intermediate favorable, intermediate unfavorable, high, and very high-risk levels. These resulted in NNI of 4619, 1182, 319, 35, and 7, respectively. Of 181,109 newly diagnosed PCa patients assessable for analyses of distant metastases (M1a-c ), 8920 (4.9%) harbored M1a-c stage: 50 (0.07%), 45 (0.1%), 161 (0.5%), 1290 (5.1%), and 7374 (22.0%) in low, intermediate favorable, intermediate unfavorable, high, and very high-risk. These resulted in NNI of 1347, 602, 174, 20, and 5, respectively.CONCLUSIONS: Our observations perfectly validated the NCCN recommendations for imaging in newly diagnosed high and very high-risk PCa patients. However, in unfavorable intermediate-risk PCa patients, in whom bone and soft tissue imaging is recommended, the NNI might be somewhat elevated to support routine imaging in clinical practice.",
keywords = "Humans, Lymph Nodes/pathology, Lymphatic Metastasis/pathology, Male, Pelvis/pathology, Prostatic Neoplasms/pathology",
author = "Gabriele Sorce and Benedikt Hoeh and Flammia, {Rocco S} and Francesco Chierigo and Lukas Hohenhorst and Andrea Panunzio and Nancy Nimer and Zhe Tian and Giorgio Gandaglia and Derya Tilki and Carlo Terrone and Michele Gallucci and Chun, {Felix K H} and Alessandro Antonelli and Fred Saad and Shariat, {Shahrokh F} and Francesco Montorsi and Alberto Briganti and Karakiewicz, {Pierre I}",
note = "{\textcopyright} 2022 Wiley Periodicals LLC.",
year = "2022",
month = sep,
doi = "10.1002/pros.24376",
language = "English",
volume = "82",
pages = "1210--1218",
journal = "PROSTATE",
issn = "0270-4137",
publisher = "Wiley-Liss Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Rates of metastatic prostate cancer in newly diagnosed patients: Numbers needed to image according to risk level

AU - Sorce, Gabriele

AU - Hoeh, Benedikt

AU - Flammia, Rocco S

AU - Chierigo, Francesco

AU - Hohenhorst, Lukas

AU - Panunzio, Andrea

AU - Nimer, Nancy

AU - Tian, Zhe

AU - Gandaglia, Giorgio

AU - Tilki, Derya

AU - Terrone, Carlo

AU - Gallucci, Michele

AU - Chun, Felix K H

AU - Antonelli, Alessandro

AU - Saad, Fred

AU - Shariat, Shahrokh F

AU - Montorsi, Francesco

AU - Briganti, Alberto

AU - Karakiewicz, Pierre I

N1 - © 2022 Wiley Periodicals LLC.

PY - 2022/9

Y1 - 2022/9

N2 - BACKGROUND: The numbers needed to image to identify pelvic lymph node and/or distant metastases in newly diagnosed prostate cancer (PCa) patients according to risk level are unknown.METHODS: Relying on Surveillance, Epidemiology, and End Results (2010-2016), we tabulated rates and proportions of patients with (a) lymph node or (b) distant metastases according to National Comprehensive Cancer Network (NCCN) risk level and calculated the number needed to image (NNI) for both endpoints. Multivariable logistic regression analyses were performed.RESULTS: Of 145,939 newly diagnosed PCa patients assessable for analyses of pelvic lymph node metastases (cN1), 4559 (3.1%) harbored cN1 stage: 13 (0.02%), 18 (0.08%), 63 (0.3%), 512 (2.8%), and 3954 (14.9%) in low, intermediate favorable, intermediate unfavorable, high, and very high-risk levels. These resulted in NNI of 4619, 1182, 319, 35, and 7, respectively. Of 181,109 newly diagnosed PCa patients assessable for analyses of distant metastases (M1a-c ), 8920 (4.9%) harbored M1a-c stage: 50 (0.07%), 45 (0.1%), 161 (0.5%), 1290 (5.1%), and 7374 (22.0%) in low, intermediate favorable, intermediate unfavorable, high, and very high-risk. These resulted in NNI of 1347, 602, 174, 20, and 5, respectively.CONCLUSIONS: Our observations perfectly validated the NCCN recommendations for imaging in newly diagnosed high and very high-risk PCa patients. However, in unfavorable intermediate-risk PCa patients, in whom bone and soft tissue imaging is recommended, the NNI might be somewhat elevated to support routine imaging in clinical practice.

AB - BACKGROUND: The numbers needed to image to identify pelvic lymph node and/or distant metastases in newly diagnosed prostate cancer (PCa) patients according to risk level are unknown.METHODS: Relying on Surveillance, Epidemiology, and End Results (2010-2016), we tabulated rates and proportions of patients with (a) lymph node or (b) distant metastases according to National Comprehensive Cancer Network (NCCN) risk level and calculated the number needed to image (NNI) for both endpoints. Multivariable logistic regression analyses were performed.RESULTS: Of 145,939 newly diagnosed PCa patients assessable for analyses of pelvic lymph node metastases (cN1), 4559 (3.1%) harbored cN1 stage: 13 (0.02%), 18 (0.08%), 63 (0.3%), 512 (2.8%), and 3954 (14.9%) in low, intermediate favorable, intermediate unfavorable, high, and very high-risk levels. These resulted in NNI of 4619, 1182, 319, 35, and 7, respectively. Of 181,109 newly diagnosed PCa patients assessable for analyses of distant metastases (M1a-c ), 8920 (4.9%) harbored M1a-c stage: 50 (0.07%), 45 (0.1%), 161 (0.5%), 1290 (5.1%), and 7374 (22.0%) in low, intermediate favorable, intermediate unfavorable, high, and very high-risk. These resulted in NNI of 1347, 602, 174, 20, and 5, respectively.CONCLUSIONS: Our observations perfectly validated the NCCN recommendations for imaging in newly diagnosed high and very high-risk PCa patients. However, in unfavorable intermediate-risk PCa patients, in whom bone and soft tissue imaging is recommended, the NNI might be somewhat elevated to support routine imaging in clinical practice.

KW - Humans

KW - Lymph Nodes/pathology

KW - Lymphatic Metastasis/pathology

KW - Male

KW - Pelvis/pathology

KW - Prostatic Neoplasms/pathology

U2 - 10.1002/pros.24376

DO - 10.1002/pros.24376

M3 - SCORING: Journal article

C2 - 35652586

VL - 82

SP - 1210

EP - 1218

JO - PROSTATE

JF - PROSTATE

SN - 0270-4137

IS - 12

ER -