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Rat tumors following fractionated irradiation

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Rat tumors following fractionated irradiation. / Bartel-Friedrich, S; Friedrich, R E; Arps, H.

In: ANTICANCER RES, Vol. 19, No. 4A, 1999, p. 2725-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bartel-Friedrich, S, Friedrich, RE & Arps, H 1999, 'Rat tumors following fractionated irradiation', ANTICANCER RES, vol. 19, no. 4A, pp. 2725-6.

APA

Bartel-Friedrich, S., Friedrich, R. E., & Arps, H. (1999). Rat tumors following fractionated irradiation. ANTICANCER RES, 19(4A), 2725-6.

Vancouver

Bartel-Friedrich S, Friedrich RE, Arps H. Rat tumors following fractionated irradiation. ANTICANCER RES. 1999;19(4A):2725-6.

Bibtex

@article{6938464c1be64cc4a66f3116eddbf179,
title = "Rat tumors following fractionated irradiation",
abstract = "BACKGROUND: Rats are susceptible to irradiation and can develop benign and malignant tumors either spontaneously or in the field of irradiation. In the head and neck region, there are no reports available on the type of tumor after fractionated irradiation using a human therapy protocol.MATERIAL AND METHODS: We analyzed 19 tumors, in 19 rats, which developed after external X-irradiation of the left neck area in Wistar rats (2 Gy/day, monofractions, 5 days/week, total dosage 60 Gy) and compared the findings with tumors in untreated rats of the same strain.RESULTS: Tumors in the irradiation field proved to be squamous cell carcinoma or adenoid cystic carcinoma (ACC), not sarcoma. These entities were sporadically found in non-irradiated rats at a higher age.CONCLUSIONS: ACC has rarely been reported in the literature on laboratory rats. The development of this highly aggressive malignant tumor can be expected 3 months to 1 year after completion of irradiation.",
keywords = "Animals, Carcinoma, Adenoid Cystic, Carcinoma, Squamous Cell, Dose Fractionation, Female, Head and Neck Neoplasms, Humans, Neoplasms, Radiation-Induced, Radiation Dosage, Rats, Rats, Wistar, X-Rays",
author = "S Bartel-Friedrich and Friedrich, {R E} and H Arps",
year = "1999",
language = "English",
volume = "19",
pages = "2725--6",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "4A",

}

RIS

TY - JOUR

T1 - Rat tumors following fractionated irradiation

AU - Bartel-Friedrich, S

AU - Friedrich, R E

AU - Arps, H

PY - 1999

Y1 - 1999

N2 - BACKGROUND: Rats are susceptible to irradiation and can develop benign and malignant tumors either spontaneously or in the field of irradiation. In the head and neck region, there are no reports available on the type of tumor after fractionated irradiation using a human therapy protocol.MATERIAL AND METHODS: We analyzed 19 tumors, in 19 rats, which developed after external X-irradiation of the left neck area in Wistar rats (2 Gy/day, monofractions, 5 days/week, total dosage 60 Gy) and compared the findings with tumors in untreated rats of the same strain.RESULTS: Tumors in the irradiation field proved to be squamous cell carcinoma or adenoid cystic carcinoma (ACC), not sarcoma. These entities were sporadically found in non-irradiated rats at a higher age.CONCLUSIONS: ACC has rarely been reported in the literature on laboratory rats. The development of this highly aggressive malignant tumor can be expected 3 months to 1 year after completion of irradiation.

AB - BACKGROUND: Rats are susceptible to irradiation and can develop benign and malignant tumors either spontaneously or in the field of irradiation. In the head and neck region, there are no reports available on the type of tumor after fractionated irradiation using a human therapy protocol.MATERIAL AND METHODS: We analyzed 19 tumors, in 19 rats, which developed after external X-irradiation of the left neck area in Wistar rats (2 Gy/day, monofractions, 5 days/week, total dosage 60 Gy) and compared the findings with tumors in untreated rats of the same strain.RESULTS: Tumors in the irradiation field proved to be squamous cell carcinoma or adenoid cystic carcinoma (ACC), not sarcoma. These entities were sporadically found in non-irradiated rats at a higher age.CONCLUSIONS: ACC has rarely been reported in the literature on laboratory rats. The development of this highly aggressive malignant tumor can be expected 3 months to 1 year after completion of irradiation.

KW - Animals

KW - Carcinoma, Adenoid Cystic

KW - Carcinoma, Squamous Cell

KW - Dose Fractionation

KW - Female

KW - Head and Neck Neoplasms

KW - Humans

KW - Neoplasms, Radiation-Induced

KW - Radiation Dosage

KW - Rats

KW - Rats, Wistar

KW - X-Rays

M3 - SCORING: Journal article

C2 - 10470229

VL - 19

SP - 2725

EP - 2726

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 4A

ER -