Rapid rule out of acute myocardial infarction using undetectable levels of high-sensitivity cardiac troponin
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Rapid rule out of acute myocardial infarction using undetectable levels of high-sensitivity cardiac troponin. / Rubini Giménez, Maria; Hoeller, Rebeca; Reichlin, Tobias; Zellweger, Christa; Twerenbold, Raphael; Reiter, Miriam; Moehring, Berit; Wildi, Karin; Mosimann, Tamina; Mueller, Mira; Meller, Bernadette; Hochgruber, Thomas; Ziller, Ronny; Sou, Seoung Mann; Murray, Karsten; Sakarikos, Konstantin; Ernst, Susanne; Gea, Joaquim; Campodarve, Isabel; Vilaplana, Carles; Haaf, Philip; Steuer, Stephan; Minners, Jan; Osswald, Stefan; Mueller, Christian.
In: INT J CARDIOL, Vol. 168, No. 4, 09.10.2013, p. 3896-3901.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Rapid rule out of acute myocardial infarction using undetectable levels of high-sensitivity cardiac troponin
AU - Rubini Giménez, Maria
AU - Hoeller, Rebeca
AU - Reichlin, Tobias
AU - Zellweger, Christa
AU - Twerenbold, Raphael
AU - Reiter, Miriam
AU - Moehring, Berit
AU - Wildi, Karin
AU - Mosimann, Tamina
AU - Mueller, Mira
AU - Meller, Bernadette
AU - Hochgruber, Thomas
AU - Ziller, Ronny
AU - Sou, Seoung Mann
AU - Murray, Karsten
AU - Sakarikos, Konstantin
AU - Ernst, Susanne
AU - Gea, Joaquim
AU - Campodarve, Isabel
AU - Vilaplana, Carles
AU - Haaf, Philip
AU - Steuer, Stephan
AU - Minners, Jan
AU - Osswald, Stefan
AU - Mueller, Christian
N1 - Funding Information: This study was supported by research grants from the Swiss National Science Foundation ( PP00B-102853 ), the Swiss Heart Foundation , Abbott , Roche , Siemens , and the Department of Internal Medicine, University Hospital Basel . Funding Information: Prof. Mueller has received research grants from the Swiss National Science Foundation (PP00B-102853) and the Swiss Heart Foundation, the StiftungfürkardiovaskuläreForschung Basel, 8sense, Abbott, ALERE, Brahms, Critical Diagnostics, Nanosphere, Roche, Siemens, and the Department of Internal Medicine, of the University Hospital Basel, as well as speaker honoraria from Abbott, ALERE, Brahms, Novartis, Roche, and Siemens. We disclose that Dr. Reichlin has received research grants from the Swiss National Science Foundation (PASMP3-136995), the Swiss Heart Foundation, the University of Basel, the Professor Max Cloetta Foundation and the Department of Internal Medicine, University Hospital Basel as well as speakers honoraria from Brahms and Roche. All other authors declare that they have no conflict of interest with this study. The hs-cTn assays were donated by their respective manufacturers, who had no role in the design of the study, the analysis of the data, the preparation of the manuscript, or the decision to submit the manuscript for publication.
PY - 2013/10/9
Y1 - 2013/10/9
N2 - Background We examined whether undetectable levels of high-sensitivity cardiac Troponin (hs-cTn) can be used to rule out acute myocardial infarction (AMI) with a single blood draw at presentation to the emergency department (ED). Methods and results In a prospective multicenter study we used 4 different hs-cTn assays (hs-cTnT Roche, and hs-cTnI Siemens, hs-cTnI Beckman Coulter and hs-cTnI Abbott) in consecutive patients presenting with acute chest pain. The final diagnosis of AMI was adjudicated by two independent cardiologists using all available data including serial hs-cTnT levels. Mean follow up was 24 months. Among 2072 consecutive patients with available hs-cTnT levels, 21% had an adjudicated diagnosis of AMI. Among AMI patients, 98.2% had initially detectable levels of hs-cTnT (sensitivity 98.2%, 95%CI 96.3%-99.2%, negative predictive value (NPV) 98.6%, 95%CI 97.0%-99.3%). Undetectable levels of hs-cTnT ruled out AMI in 26.5% of patients at presentation. The NPV was similar with the three hs-cTnI assays: among 1180 consecutive patients with available hs-cTnI (Siemens), the NPV was 98.8%; among 1151 consecutive patients with available hs-cTnI (Beckman Coulter), the NPV was 99.2%; among 1567 consecutive patients with available hs-cTnI (Abbott), the NPV was 100.0%. The percentage of patients with undetectable levels of hs-cTnI was similar among the three hs-cTnI assays and ranged from 11.4% to 13.9%. Conclusions Undetectable levels of hs-cTn at presentation have a very high NPV and seem to allow the simple and rapid rule out of AMI. This criteria applies to much more patients with hs-TnT as compared to the investigated hs-cTnI assays.
AB - Background We examined whether undetectable levels of high-sensitivity cardiac Troponin (hs-cTn) can be used to rule out acute myocardial infarction (AMI) with a single blood draw at presentation to the emergency department (ED). Methods and results In a prospective multicenter study we used 4 different hs-cTn assays (hs-cTnT Roche, and hs-cTnI Siemens, hs-cTnI Beckman Coulter and hs-cTnI Abbott) in consecutive patients presenting with acute chest pain. The final diagnosis of AMI was adjudicated by two independent cardiologists using all available data including serial hs-cTnT levels. Mean follow up was 24 months. Among 2072 consecutive patients with available hs-cTnT levels, 21% had an adjudicated diagnosis of AMI. Among AMI patients, 98.2% had initially detectable levels of hs-cTnT (sensitivity 98.2%, 95%CI 96.3%-99.2%, negative predictive value (NPV) 98.6%, 95%CI 97.0%-99.3%). Undetectable levels of hs-cTnT ruled out AMI in 26.5% of patients at presentation. The NPV was similar with the three hs-cTnI assays: among 1180 consecutive patients with available hs-cTnI (Siemens), the NPV was 98.8%; among 1151 consecutive patients with available hs-cTnI (Beckman Coulter), the NPV was 99.2%; among 1567 consecutive patients with available hs-cTnI (Abbott), the NPV was 100.0%. The percentage of patients with undetectable levels of hs-cTnI was similar among the three hs-cTnI assays and ranged from 11.4% to 13.9%. Conclusions Undetectable levels of hs-cTn at presentation have a very high NPV and seem to allow the simple and rapid rule out of AMI. This criteria applies to much more patients with hs-TnT as compared to the investigated hs-cTnI assays.
KW - Acute myocardial infarction
KW - High sensitive cardiac troponin
KW - Rapid rule-out
UR - http://www.scopus.com/inward/record.url?scp=84886304639&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2013.06.049
DO - 10.1016/j.ijcard.2013.06.049
M3 - SCORING: Journal article
C2 - 23876467
AN - SCOPUS:84886304639
VL - 168
SP - 3896
EP - 3901
JO - INT J CARDIOL
JF - INT J CARDIOL
SN - 0167-5273
IS - 4
ER -