Rapid isotropic diffusion mapping without susceptibility artifacts: whole brain studies using diffusion-weighted single-shot STEAM MR imaging.
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Rapid isotropic diffusion mapping without susceptibility artifacts: whole brain studies using diffusion-weighted single-shot STEAM MR imaging. / Nolte, U G; Finsterbusch, Jürgen; Frahm, J.
In: MAGN RESON MED, Vol. 44, No. 5, 5, 2000, p. 731-736.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Rapid isotropic diffusion mapping without susceptibility artifacts: whole brain studies using diffusion-weighted single-shot STEAM MR imaging.
AU - Nolte, U G
AU - Finsterbusch, Jürgen
AU - Frahm, J
PY - 2000
Y1 - 2000
N2 - A subsecond magnetic resonance imaging (MRI) technique for isotropic diffusion mapping is described which, in contrast to echo-planar imaging (EPI), is insensitive to resonance offsets, i.e., tissue susceptibility differences, magnetic field inhomogeneities, and chemical shifts. It combines a diffusion-weighted (DW) spin-echo preparation period and a high-speed stimulated echo acquisition mode (STEAM) MRI sequence and yields single-shot images within measuring times of 559 msec (80 echoes). Here, diffusion encoding involved one scan without DW, three DW scans with b = 490 sec mm(-2), and three DW scans with b = 1000 sec mm(-2) (orthogonal gradient orientations). An automated on-line evaluation resulted in isotropic DW images as well as ADC maps (trace of the diffusion tensor). Experiments at 2.0 T covered the brain of healthy subjects in 20 contiguous sections of 6 mm thickness and 2.0 x 2.0 mm(2) in-plane resolution within a total measuring time of 78 sec. High-resolution studies at 1.0 x 1.0 mm(2) (interpolated from 2.0 x 1.0 mm(2) acquisitions) were obtained within 5 min 13 sec using four averages. In comparison with EPI, DW single-shot STEAM MRI exhibits only about half the SNR, but completely avoids regional signal losses, high intensity artifacts, and geometric distortions.
AB - A subsecond magnetic resonance imaging (MRI) technique for isotropic diffusion mapping is described which, in contrast to echo-planar imaging (EPI), is insensitive to resonance offsets, i.e., tissue susceptibility differences, magnetic field inhomogeneities, and chemical shifts. It combines a diffusion-weighted (DW) spin-echo preparation period and a high-speed stimulated echo acquisition mode (STEAM) MRI sequence and yields single-shot images within measuring times of 559 msec (80 echoes). Here, diffusion encoding involved one scan without DW, three DW scans with b = 490 sec mm(-2), and three DW scans with b = 1000 sec mm(-2) (orthogonal gradient orientations). An automated on-line evaluation resulted in isotropic DW images as well as ADC maps (trace of the diffusion tensor). Experiments at 2.0 T covered the brain of healthy subjects in 20 contiguous sections of 6 mm thickness and 2.0 x 2.0 mm(2) in-plane resolution within a total measuring time of 78 sec. High-resolution studies at 1.0 x 1.0 mm(2) (interpolated from 2.0 x 1.0 mm(2) acquisitions) were obtained within 5 min 13 sec using four averages. In comparison with EPI, DW single-shot STEAM MRI exhibits only about half the SNR, but completely avoids regional signal losses, high intensity artifacts, and geometric distortions.
M3 - SCORING: Zeitschriftenaufsatz
VL - 44
SP - 731
EP - 736
JO - MAGN RESON MED
JF - MAGN RESON MED
SN - 0740-3194
IS - 5
M1 - 5
ER -
