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Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis

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Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis. / Pöttgen, Jana; Moss-Morris, Rona; Wendebourg, Janina-Maria; Feddersen, Lena; Lau, Stefanie; Köpke, Sascha; Meyer, Björn; Friede, Tim; Penner, Iris-Katharina; Heesen, Christoph; Gold, Stefan M.

In: J NEUROL NEUROSUR PS, Vol. 89, No. 9, 09.2018, p. 970-976.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pöttgen, J, Moss-Morris, R, Wendebourg, J-M, Feddersen, L, Lau, S, Köpke, S, Meyer, B, Friede, T, Penner, I-K, Heesen, C & Gold, SM 2018, 'Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis', J NEUROL NEUROSUR PS, vol. 89, no. 9, pp. 970-976. https://doi.org/10.1136/jnnp-2017-317463

APA

Pöttgen, J., Moss-Morris, R., Wendebourg, J-M., Feddersen, L., Lau, S., Köpke, S., Meyer, B., Friede, T., Penner, I-K., Heesen, C., & Gold, S. M. (2018). Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis. J NEUROL NEUROSUR PS, 89(9), 970-976. https://doi.org/10.1136/jnnp-2017-317463

Vancouver

Pöttgen J, Moss-Morris R, Wendebourg J-M, Feddersen L, Lau S, Köpke S et al. Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis. J NEUROL NEUROSUR PS. 2018 Sep;89(9):970-976. https://doi.org/10.1136/jnnp-2017-317463

Bibtex

@article{5713d33d37214112a69d35ae032259c6,
title = "Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis",
abstract = "OBJECTIVE: Fatigue is a major disabling symptom in many chronic diseases including multiple sclerosis (MS), but treatment options are limited.Here, we tested the effectiveness of a self-guided , interactive, online fatigue management programme (ELEVIDA) based on principles of cognitive behavioural therapy (CBT) and related psychotherapeutic approaches (eg, mindfulness) for reducing fatigue in MS.METHODS: Patients with MS and self-reported fatigue were recruited via the website of the German MS Society and assigned via an automated randomisation generator (1:1, no blocking or stratification) to a 12-week online intervention (ELEVIDA, n=139, 82% female, mean age 40.8, median patient determined disease steps (PDDS) 3.0) or a waitlist control group (n=136, 79% female, mean age 41.9, median PDDS 3.0). The primary outcome was the Chalder Fatigue Scale. Outcomes were assessed at baseline, at week 12 (postintervention) and at follow-up (week 24).RESULTS: Compared with the control group, significantly greater reductions in Chalder Fatigue Scale scores were seen in the ELEVIDA group at week 12 (primary endpoint, intention-to-treat analysis: between-group mean difference 2.74 points; 95% CI 1.16 to 4.32; p=0.0007; effect size d=0.53), with effects sustained at week 24 (intention-to-treat analysis: between-group mean difference 2.19 points; 95% CI 0.57 to 3.82; p=0.0080).CONCLUSIONS: Our trial provides evidence for the effectiveness of a self-guided , internet-based intervention to reduce fatigue in MS. Interventions such as ELEVIDA may be a suitable low barrier, cost-effective treatment option for MS fatigue.TRIAL REGISTRATION NUMBER: ISRCTN registry (number ISRCTN25692173).",
keywords = "Journal Article",
author = "Jana P{\"o}ttgen and Rona Moss-Morris and Janina-Maria Wendebourg and Lena Feddersen and Stefanie Lau and Sascha K{\"o}pke and Bj{\"o}rn Meyer and Tim Friede and Iris-Katharina Penner and Christoph Heesen and Gold, {Stefan M}",
note = "{\textcopyright} Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.",
year = "2018",
month = sep,
doi = "10.1136/jnnp-2017-317463",
language = "English",
volume = "89",
pages = "970--976",
journal = "J NEUROL NEUROSUR PS",
issn = "0022-3050",
publisher = "BMJ PUBLISHING GROUP",
number = "9",

}

RIS

TY - JOUR

T1 - Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis

AU - Pöttgen, Jana

AU - Moss-Morris, Rona

AU - Wendebourg, Janina-Maria

AU - Feddersen, Lena

AU - Lau, Stefanie

AU - Köpke, Sascha

AU - Meyer, Björn

AU - Friede, Tim

AU - Penner, Iris-Katharina

AU - Heesen, Christoph

AU - Gold, Stefan M

N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2018/9

Y1 - 2018/9

N2 - OBJECTIVE: Fatigue is a major disabling symptom in many chronic diseases including multiple sclerosis (MS), but treatment options are limited.Here, we tested the effectiveness of a self-guided , interactive, online fatigue management programme (ELEVIDA) based on principles of cognitive behavioural therapy (CBT) and related psychotherapeutic approaches (eg, mindfulness) for reducing fatigue in MS.METHODS: Patients with MS and self-reported fatigue were recruited via the website of the German MS Society and assigned via an automated randomisation generator (1:1, no blocking or stratification) to a 12-week online intervention (ELEVIDA, n=139, 82% female, mean age 40.8, median patient determined disease steps (PDDS) 3.0) or a waitlist control group (n=136, 79% female, mean age 41.9, median PDDS 3.0). The primary outcome was the Chalder Fatigue Scale. Outcomes were assessed at baseline, at week 12 (postintervention) and at follow-up (week 24).RESULTS: Compared with the control group, significantly greater reductions in Chalder Fatigue Scale scores were seen in the ELEVIDA group at week 12 (primary endpoint, intention-to-treat analysis: between-group mean difference 2.74 points; 95% CI 1.16 to 4.32; p=0.0007; effect size d=0.53), with effects sustained at week 24 (intention-to-treat analysis: between-group mean difference 2.19 points; 95% CI 0.57 to 3.82; p=0.0080).CONCLUSIONS: Our trial provides evidence for the effectiveness of a self-guided , internet-based intervention to reduce fatigue in MS. Interventions such as ELEVIDA may be a suitable low barrier, cost-effective treatment option for MS fatigue.TRIAL REGISTRATION NUMBER: ISRCTN registry (number ISRCTN25692173).

AB - OBJECTIVE: Fatigue is a major disabling symptom in many chronic diseases including multiple sclerosis (MS), but treatment options are limited.Here, we tested the effectiveness of a self-guided , interactive, online fatigue management programme (ELEVIDA) based on principles of cognitive behavioural therapy (CBT) and related psychotherapeutic approaches (eg, mindfulness) for reducing fatigue in MS.METHODS: Patients with MS and self-reported fatigue were recruited via the website of the German MS Society and assigned via an automated randomisation generator (1:1, no blocking or stratification) to a 12-week online intervention (ELEVIDA, n=139, 82% female, mean age 40.8, median patient determined disease steps (PDDS) 3.0) or a waitlist control group (n=136, 79% female, mean age 41.9, median PDDS 3.0). The primary outcome was the Chalder Fatigue Scale. Outcomes were assessed at baseline, at week 12 (postintervention) and at follow-up (week 24).RESULTS: Compared with the control group, significantly greater reductions in Chalder Fatigue Scale scores were seen in the ELEVIDA group at week 12 (primary endpoint, intention-to-treat analysis: between-group mean difference 2.74 points; 95% CI 1.16 to 4.32; p=0.0007; effect size d=0.53), with effects sustained at week 24 (intention-to-treat analysis: between-group mean difference 2.19 points; 95% CI 0.57 to 3.82; p=0.0080).CONCLUSIONS: Our trial provides evidence for the effectiveness of a self-guided , internet-based intervention to reduce fatigue in MS. Interventions such as ELEVIDA may be a suitable low barrier, cost-effective treatment option for MS fatigue.TRIAL REGISTRATION NUMBER: ISRCTN registry (number ISRCTN25692173).

KW - Journal Article

U2 - 10.1136/jnnp-2017-317463

DO - 10.1136/jnnp-2017-317463

M3 - SCORING: Journal article

C2 - 29549193

VL - 89

SP - 970

EP - 976

JO - J NEUROL NEUROSUR PS

JF - J NEUROL NEUROSUR PS

SN - 0022-3050

IS - 9

ER -