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ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline.

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ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline. / Hentschke, Moritz; Wolters, Manuel; Sobottka, Ingo; Rohde, Holger; Aepfelbacher, Martin.

In: ANTIMICROB AGENTS CH, Vol. 54, No. 6, 6, 2010, p. 2720-2723.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hentschke, M, Wolters, M, Sobottka, I, Rohde, H & Aepfelbacher, M 2010, 'ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline.', ANTIMICROB AGENTS CH, vol. 54, no. 6, 6, pp. 2720-2723. <http://www.ncbi.nlm.nih.gov/pubmed/20350947?dopt=Citation>

APA

Hentschke, M., Wolters, M., Sobottka, I., Rohde, H., & Aepfelbacher, M. (2010). ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline. ANTIMICROB AGENTS CH, 54(6), 2720-2723. [6]. http://www.ncbi.nlm.nih.gov/pubmed/20350947?dopt=Citation

Vancouver

Hentschke M, Wolters M, Sobottka I, Rohde H, Aepfelbacher M. ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline. ANTIMICROB AGENTS CH. 2010;54(6):2720-2723. 6.

Bibtex

@article{4494c3b1f5de4988b6673aee2cbca3fb,
title = "ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline.",
abstract = "Five Klebsiella pneumoniae isolates with reduced susceptibility to tigecycline (MIC, 2 microg/ml) were analyzed. A gene homologous to ramR of Salmonella enterica was identified in Klebsiella pneumoniae. Sequencing of ramR in the nonsusceptible Klebsiella strains revealed deletions, insertions, and point mutations. Transformation of mutants with wild-type ramR genes, but not with mutant ramR genes, restored susceptibility to tigecycline and repressed overexpression of ramA and acrB. Thus, this study reveals a molecular mechanism for tigecycline resistance in Klebsiella pneumoniae.",
author = "Moritz Hentschke and Manuel Wolters and Ingo Sobottka and Holger Rohde and Martin Aepfelbacher",
year = "2010",
language = "Deutsch",
volume = "54",
pages = "2720--2723",
journal = "ANTIMICROB AGENTS CH",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "6",

}

RIS

TY - JOUR

T1 - ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline.

AU - Hentschke, Moritz

AU - Wolters, Manuel

AU - Sobottka, Ingo

AU - Rohde, Holger

AU - Aepfelbacher, Martin

PY - 2010

Y1 - 2010

N2 - Five Klebsiella pneumoniae isolates with reduced susceptibility to tigecycline (MIC, 2 microg/ml) were analyzed. A gene homologous to ramR of Salmonella enterica was identified in Klebsiella pneumoniae. Sequencing of ramR in the nonsusceptible Klebsiella strains revealed deletions, insertions, and point mutations. Transformation of mutants with wild-type ramR genes, but not with mutant ramR genes, restored susceptibility to tigecycline and repressed overexpression of ramA and acrB. Thus, this study reveals a molecular mechanism for tigecycline resistance in Klebsiella pneumoniae.

AB - Five Klebsiella pneumoniae isolates with reduced susceptibility to tigecycline (MIC, 2 microg/ml) were analyzed. A gene homologous to ramR of Salmonella enterica was identified in Klebsiella pneumoniae. Sequencing of ramR in the nonsusceptible Klebsiella strains revealed deletions, insertions, and point mutations. Transformation of mutants with wild-type ramR genes, but not with mutant ramR genes, restored susceptibility to tigecycline and repressed overexpression of ramA and acrB. Thus, this study reveals a molecular mechanism for tigecycline resistance in Klebsiella pneumoniae.

M3 - SCORING: Zeitschriftenaufsatz

VL - 54

SP - 2720

EP - 2723

JO - ANTIMICROB AGENTS CH

JF - ANTIMICROB AGENTS CH

SN - 0066-4804

IS - 6

M1 - 6

ER -