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RAI3 is overexpressed in gastric adenocarcinoma but unrelated to prognosis

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RAI3 is overexpressed in gastric adenocarcinoma but unrelated to prognosis. / Melling, Nathaniel; Bachmann, Kai; Bockhorn, Maximillian; Mann, Oliver; Izbicki, Jakob Robert; Grupp, Katharina.

In: INT J CLIN EXP PATHO, Vol. 12, No. 2, 2019, p. 606-612.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Melling, N, Bachmann, K, Bockhorn, M, Mann, O, Izbicki, JR & Grupp, K 2019, 'RAI3 is overexpressed in gastric adenocarcinoma but unrelated to prognosis', INT J CLIN EXP PATHO, vol. 12, no. 2, pp. 606-612.

APA

Melling, N., Bachmann, K., Bockhorn, M., Mann, O., Izbicki, J. R., & Grupp, K. (2019). RAI3 is overexpressed in gastric adenocarcinoma but unrelated to prognosis. INT J CLIN EXP PATHO, 12(2), 606-612.

Vancouver

Melling N, Bachmann K, Bockhorn M, Mann O, Izbicki JR, Grupp K. RAI3 is overexpressed in gastric adenocarcinoma but unrelated to prognosis. INT J CLIN EXP PATHO. 2019;12(2):606-612.

Bibtex

@article{a0b35e48b68446e282102f5c7f8aeac1,
title = "RAI3 is overexpressed in gastric adenocarcinoma but unrelated to prognosis",
abstract = "PURPOSE: Retinoic acid-induced gene 3 (RAI3) has been associated with tumorigeneses in several cancer types. To clarify the clinical significance of RAI3 expression in premalignant and malignant gastric epithelium, RAI3 protein expression was assessed by immunohistochemistry on tissue microarrays (TMAs) containing 140 gastric dysplasia and 230 GC samples.FINDINGS: RAI3 protein expression was predominantly localized in the cell membrane and was detectable in low intensities in most of the benign gastric tissue samples. RAI3 expression was found in increased intensities in premalignant and malignant epithelium relative to non-malignant gastric epithelium (P < 0.0001). High RAI3 expression was found in 66.2% of interpretable gastric adenocarcinomas and was associated with advanced pathological tumor stage (P = 0.0014) and positive lymph node status (P = 0.0137) but was unrelated to overall survival of patients (P = 0.3743).CONCLUSION: The deregulation of RAI3 in premalignant and gastric epithelium suggests a relevant role of RAI3 during gastric carcinogenesis. Additionally, RAI3 overexpression defines a subset of GCs with aggressive tumor features. However, since RAI3 expression was not associated with clinical outcome of patients, RAI3 cannot be considered as a prognostic biomarker in patients with GCs.",
author = "Nathaniel Melling and Kai Bachmann and Maximillian Bockhorn and Oliver Mann and Izbicki, {Jakob Robert} and Katharina Grupp",
note = "IJCEP Copyright {\textcopyright} 2019.",
year = "2019",
language = "English",
volume = "12",
pages = "606--612",
journal = "INT J CLIN EXP PATHO",
issn = "1936-2625",
publisher = "e-Century Publishing Corporation",
number = "2",

}

RIS

TY - JOUR

T1 - RAI3 is overexpressed in gastric adenocarcinoma but unrelated to prognosis

AU - Melling, Nathaniel

AU - Bachmann, Kai

AU - Bockhorn, Maximillian

AU - Mann, Oliver

AU - Izbicki, Jakob Robert

AU - Grupp, Katharina

N1 - IJCEP Copyright © 2019.

PY - 2019

Y1 - 2019

N2 - PURPOSE: Retinoic acid-induced gene 3 (RAI3) has been associated with tumorigeneses in several cancer types. To clarify the clinical significance of RAI3 expression in premalignant and malignant gastric epithelium, RAI3 protein expression was assessed by immunohistochemistry on tissue microarrays (TMAs) containing 140 gastric dysplasia and 230 GC samples.FINDINGS: RAI3 protein expression was predominantly localized in the cell membrane and was detectable in low intensities in most of the benign gastric tissue samples. RAI3 expression was found in increased intensities in premalignant and malignant epithelium relative to non-malignant gastric epithelium (P < 0.0001). High RAI3 expression was found in 66.2% of interpretable gastric adenocarcinomas and was associated with advanced pathological tumor stage (P = 0.0014) and positive lymph node status (P = 0.0137) but was unrelated to overall survival of patients (P = 0.3743).CONCLUSION: The deregulation of RAI3 in premalignant and gastric epithelium suggests a relevant role of RAI3 during gastric carcinogenesis. Additionally, RAI3 overexpression defines a subset of GCs with aggressive tumor features. However, since RAI3 expression was not associated with clinical outcome of patients, RAI3 cannot be considered as a prognostic biomarker in patients with GCs.

AB - PURPOSE: Retinoic acid-induced gene 3 (RAI3) has been associated with tumorigeneses in several cancer types. To clarify the clinical significance of RAI3 expression in premalignant and malignant gastric epithelium, RAI3 protein expression was assessed by immunohistochemistry on tissue microarrays (TMAs) containing 140 gastric dysplasia and 230 GC samples.FINDINGS: RAI3 protein expression was predominantly localized in the cell membrane and was detectable in low intensities in most of the benign gastric tissue samples. RAI3 expression was found in increased intensities in premalignant and malignant epithelium relative to non-malignant gastric epithelium (P < 0.0001). High RAI3 expression was found in 66.2% of interpretable gastric adenocarcinomas and was associated with advanced pathological tumor stage (P = 0.0014) and positive lymph node status (P = 0.0137) but was unrelated to overall survival of patients (P = 0.3743).CONCLUSION: The deregulation of RAI3 in premalignant and gastric epithelium suggests a relevant role of RAI3 during gastric carcinogenesis. Additionally, RAI3 overexpression defines a subset of GCs with aggressive tumor features. However, since RAI3 expression was not associated with clinical outcome of patients, RAI3 cannot be considered as a prognostic biomarker in patients with GCs.

M3 - SCORING: Journal article

C2 - 31933866

VL - 12

SP - 606

EP - 612

JO - INT J CLIN EXP PATHO

JF - INT J CLIN EXP PATHO

SN - 1936-2625

IS - 2

ER -