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Radioprotektive Wirksamkeit von Amifostin auf die Speicheldrüsen der Ratte unter fraktionierter Bestrahlung

Standard

Radioprotektive Wirksamkeit von Amifostin auf die Speicheldrüsen der Ratte unter fraktionierter Bestrahlung. / Sagowski, C; Wenzel, S; Neumann, B; Kehrl, W; Zywietz, F; Roeser, K; Ussmüller, J.

In: HNO, Vol. 50, No. 2, 02.2002, p. 139-45.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sagowski, C, Wenzel, S, Neumann, B, Kehrl, W, Zywietz, F, Roeser, K & Ussmüller, J 2002, 'Radioprotektive Wirksamkeit von Amifostin auf die Speicheldrüsen der Ratte unter fraktionierter Bestrahlung', HNO, vol. 50, no. 2, pp. 139-45.

APA

Sagowski, C., Wenzel, S., Neumann, B., Kehrl, W., Zywietz, F., Roeser, K., & Ussmüller, J. (2002). Radioprotektive Wirksamkeit von Amifostin auf die Speicheldrüsen der Ratte unter fraktionierter Bestrahlung. HNO, 50(2), 139-45.

Vancouver

Sagowski C, Wenzel S, Neumann B, Kehrl W, Zywietz F, Roeser K et al. Radioprotektive Wirksamkeit von Amifostin auf die Speicheldrüsen der Ratte unter fraktionierter Bestrahlung. HNO. 2002 Feb;50(2):139-45.

Bibtex

@article{2c0763d7bcc1457dbc4208264f022232,
title = "Radioprotektive Wirksamkeit von Amifostin auf die Speicheldr{\"u}sen der Ratte unter fraktionierter Bestrahlung",
abstract = "BACKGROUND: The aim of this study was to evaluate the cytoprotective potency of amifostine during a fractioned irradiation of salivary glands but also on the tumor response of rhabdomyosarcomas R1H in rats.METHOD: The head-neck-area of male WAG/RijH rats and the tumor in the flank were irradiated with 60Co-gamma-rays (60 Gy/30 f/6 weeks). Amifostine (250 mg/m2) was applicated 15 min before irradiation. The control group was treated with an equal volume of physiologic sodium chloride. The salivary glands were exstirpated and examined histopathologically. Tumour volume was measured, the body-weight of rats determined.RESULTS: A dose dependent radiosialadenitis developed in all salivary glands. Amifostine had no influence on the response of R1H tumours to radiation. The animal weight loss in the amifostine group was higher as compared to control group.CONCLUSIONS: No cytoprotective effects on acute toxicity of salivary glands of rats could be detected under irradiation with synchronous application of amifostine. In addition, no effects on tumor response were observed. The general animal constitution decreased by additional medication of amifostine.",
keywords = "Amifostine, Animals, Cobalt Radioisotopes, Dose Fractionation, Male, Neoplasm Transplantation, Radiation Injuries, Experimental, Radiation-Protective Agents, Radioisotope Teletherapy, Rats, Rats, Inbred Strains, Rhabdomyosarcoma, Salivary Glands, Soft Tissue Neoplasms, English Abstract, Journal Article",
author = "C Sagowski and S Wenzel and B Neumann and W Kehrl and F Zywietz and K Roeser and J Ussm{\"u}ller",
year = "2002",
month = feb,
language = "Deutsch",
volume = "50",
pages = "139--45",
journal = "HNO",
issn = "0017-6192",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Radioprotektive Wirksamkeit von Amifostin auf die Speicheldrüsen der Ratte unter fraktionierter Bestrahlung

AU - Sagowski, C

AU - Wenzel, S

AU - Neumann, B

AU - Kehrl, W

AU - Zywietz, F

AU - Roeser, K

AU - Ussmüller, J

PY - 2002/2

Y1 - 2002/2

N2 - BACKGROUND: The aim of this study was to evaluate the cytoprotective potency of amifostine during a fractioned irradiation of salivary glands but also on the tumor response of rhabdomyosarcomas R1H in rats.METHOD: The head-neck-area of male WAG/RijH rats and the tumor in the flank were irradiated with 60Co-gamma-rays (60 Gy/30 f/6 weeks). Amifostine (250 mg/m2) was applicated 15 min before irradiation. The control group was treated with an equal volume of physiologic sodium chloride. The salivary glands were exstirpated and examined histopathologically. Tumour volume was measured, the body-weight of rats determined.RESULTS: A dose dependent radiosialadenitis developed in all salivary glands. Amifostine had no influence on the response of R1H tumours to radiation. The animal weight loss in the amifostine group was higher as compared to control group.CONCLUSIONS: No cytoprotective effects on acute toxicity of salivary glands of rats could be detected under irradiation with synchronous application of amifostine. In addition, no effects on tumor response were observed. The general animal constitution decreased by additional medication of amifostine.

AB - BACKGROUND: The aim of this study was to evaluate the cytoprotective potency of amifostine during a fractioned irradiation of salivary glands but also on the tumor response of rhabdomyosarcomas R1H in rats.METHOD: The head-neck-area of male WAG/RijH rats and the tumor in the flank were irradiated with 60Co-gamma-rays (60 Gy/30 f/6 weeks). Amifostine (250 mg/m2) was applicated 15 min before irradiation. The control group was treated with an equal volume of physiologic sodium chloride. The salivary glands were exstirpated and examined histopathologically. Tumour volume was measured, the body-weight of rats determined.RESULTS: A dose dependent radiosialadenitis developed in all salivary glands. Amifostine had no influence on the response of R1H tumours to radiation. The animal weight loss in the amifostine group was higher as compared to control group.CONCLUSIONS: No cytoprotective effects on acute toxicity of salivary glands of rats could be detected under irradiation with synchronous application of amifostine. In addition, no effects on tumor response were observed. The general animal constitution decreased by additional medication of amifostine.

KW - Amifostine

KW - Animals

KW - Cobalt Radioisotopes

KW - Dose Fractionation

KW - Male

KW - Neoplasm Transplantation

KW - Radiation Injuries, Experimental

KW - Radiation-Protective Agents

KW - Radioisotope Teletherapy

KW - Rats

KW - Rats, Inbred Strains

KW - Rhabdomyosarcoma

KW - Salivary Glands

KW - Soft Tissue Neoplasms

KW - English Abstract

KW - Journal Article

M3 - SCORING: Zeitschriftenaufsatz

C2 - 12080624

VL - 50

SP - 139

EP - 145

JO - HNO

JF - HNO

SN - 0017-6192

IS - 2

ER -