Radiobiology of the rhabdomyosarcoma R1H of the rat: influence of the size of irradiation field on tumor response, tumor bed effect, and neovascularization kinetics.
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Radiobiology of the rhabdomyosarcoma R1H of the rat: influence of the size of irradiation field on tumor response, tumor bed effect, and neovascularization kinetics. / Würschmidt, F; Beck-Bornholdt, Hans-Peter; Vogler, H.
In: INT J RADIAT ONCOL, Vol. 18, No. 4, 4, 1990, p. 879-882.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Radiobiology of the rhabdomyosarcoma R1H of the rat: influence of the size of irradiation field on tumor response, tumor bed effect, and neovascularization kinetics.
AU - Würschmidt, F
AU - Beck-Bornholdt, Hans-Peter
AU - Vogler, H
PY - 1990
Y1 - 1990
N2 - R1H tumors were irradiated with a single dose of 15 Gy X rays using varying sizes of treatment fields. Damage to tumor cells and tumor stroma was determined separately by analysis of growth delay to ten times treatment volume (GD10vo) and net growth delay. GD10vo comprises irradiation effects on tumor parenchymal cells and on tumor stroma, whereas net growth delay only measures effects on tumor parenchymal cells. Stromal damage was observed to increase with increasing field size; the effect on the tumor parenchymal cells, however, was independent of the field size. An increase of GD10vo of 13 days per cm increase of field size diameter was observed. From this the velocity of neovascularization of the irradiated tumor bed was calculated to be 0.30 to 0.38 mm per day.
AB - R1H tumors were irradiated with a single dose of 15 Gy X rays using varying sizes of treatment fields. Damage to tumor cells and tumor stroma was determined separately by analysis of growth delay to ten times treatment volume (GD10vo) and net growth delay. GD10vo comprises irradiation effects on tumor parenchymal cells and on tumor stroma, whereas net growth delay only measures effects on tumor parenchymal cells. Stromal damage was observed to increase with increasing field size; the effect on the tumor parenchymal cells, however, was independent of the field size. An increase of GD10vo of 13 days per cm increase of field size diameter was observed. From this the velocity of neovascularization of the irradiated tumor bed was calculated to be 0.30 to 0.38 mm per day.
M3 - SCORING: Zeitschriftenaufsatz
VL - 18
SP - 879
EP - 882
JO - INT J RADIAT ONCOL
JF - INT J RADIAT ONCOL
SN - 0360-3016
IS - 4
M1 - 4
ER -
