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Radiation therapy after radical prostatectomy is associated with higher other-cause mortality

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Radiation therapy after radical prostatectomy is associated with higher other-cause mortality. / Würnschimmel, Christoph; Wenzel, Mike; Chierigo, Francesco; Flammia, Rocco Simone; Horlemann, Benedikt; Tian, Zhe; Saad, Fred; Briganti, Alberto; Shariat, Sharokh F; Gallucci, Michele; Suardi, Nazareno; Chun, Felix K H; Tilki, Derya; Graefen, Markus; Karakiewicz, Pierre I.

In: CANCER CAUSE CONTROL, Vol. 33, No. 5, 05.2022, p. 769-777.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Würnschimmel, C, Wenzel, M, Chierigo, F, Flammia, RS, Horlemann, B, Tian, Z, Saad, F, Briganti, A, Shariat, SF, Gallucci, M, Suardi, N, Chun, FKH, Tilki, D, Graefen, M & Karakiewicz, PI 2022, 'Radiation therapy after radical prostatectomy is associated with higher other-cause mortality', CANCER CAUSE CONTROL, vol. 33, no. 5, pp. 769-777. https://doi.org/10.1007/s10552-022-01564-z

APA

Würnschimmel, C., Wenzel, M., Chierigo, F., Flammia, R. S., Horlemann, B., Tian, Z., Saad, F., Briganti, A., Shariat, S. F., Gallucci, M., Suardi, N., Chun, F. K. H., Tilki, D., Graefen, M., & Karakiewicz, P. I. (2022). Radiation therapy after radical prostatectomy is associated with higher other-cause mortality. CANCER CAUSE CONTROL, 33(5), 769-777. https://doi.org/10.1007/s10552-022-01564-z

Vancouver

Würnschimmel C, Wenzel M, Chierigo F, Flammia RS, Horlemann B, Tian Z et al. Radiation therapy after radical prostatectomy is associated with higher other-cause mortality. CANCER CAUSE CONTROL. 2022 May;33(5):769-777. https://doi.org/10.1007/s10552-022-01564-z

Bibtex

@article{f4fd829722574b79a477ac3d0803c583,
title = "Radiation therapy after radical prostatectomy is associated with higher other-cause mortality",
abstract = "PURPOSE: To test the association between external beam radiotherapy (EBRT) after radical prostatectomy (RP) vs RP only on rates of other-cause mortality (OCM) in men with prostate cancer (PCa).PATIENTS AND METHODS: Within the 2004-2016 Surveillance, Epidemiology, and End Results database, we identified 181,849 localized PCa patients, of whom 168,041 received RP only vs 13,808 who received RP + EBRT. Cumulative incidence plots displayed OCM between RP vs RP + EBRT after propensity score matching for age, PSA, clinical T- and N-stages, and biopsy Gleason scores. Multivariable competing risks regression models addressed OCM, accounting prostate cancer-specific mortality (CSM) as a competing event. Stratifications were made according to low- vs intermediate- vs high-risk groups and additionally according to age groups of ≤ 60, 61-70, and ≥ 71 years, within each risk group.RESULTS: In low-, intermediate-, and high-risk patients, RP + EBRT rates were 2.7, 5.4 and 17.0%, respectively. After matching, 10-year OCM rates between RP and RP + EBRT were 7.7 vs 16.2% in low-, 9.4 vs 13.6% in intermediate-, and 11.4 vs 13.5% in high-risk patients (all p < 0.001), which, respectively, resulted in multivariable HR of 2.1, 1.3, and 1.2 (all p < 0.001). In subgroup analyses, excess OCM was recorded in low-risk RP + EBRT patients of all age groups (all p ≤ 0.03), but only in the older age group in intermediate-risk patients (61-70 years, p = 0.03) and finally, only in the oldest age group in high-risk patients (≥ 71 years, p = 0.02).CONCLUSION: Excess OCM was recorded in patients exposed to RT after RP. Its extent was most pronounced in low-risk patients, decreased in intermediate-risk patients, and was lowest in high-risk patients.",
keywords = "Aged, Humans, Male, Neoplasm Grading, Prostate, Prostatectomy/methods, Prostatic Neoplasms/radiotherapy, Treatment Outcome",
author = "Christoph W{\"u}rnschimmel and Mike Wenzel and Francesco Chierigo and Flammia, {Rocco Simone} and Benedikt Horlemann and Zhe Tian and Fred Saad and Alberto Briganti and Shariat, {Sharokh F} and Michele Gallucci and Nazareno Suardi and Chun, {Felix K H} and Derya Tilki and Markus Graefen and Karakiewicz, {Pierre I}",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = may,
doi = "10.1007/s10552-022-01564-z",
language = "English",
volume = "33",
pages = "769--777",
journal = "CANCER CAUSE CONTROL",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "5",

}

RIS

TY - JOUR

T1 - Radiation therapy after radical prostatectomy is associated with higher other-cause mortality

AU - Würnschimmel, Christoph

AU - Wenzel, Mike

AU - Chierigo, Francesco

AU - Flammia, Rocco Simone

AU - Horlemann, Benedikt

AU - Tian, Zhe

AU - Saad, Fred

AU - Briganti, Alberto

AU - Shariat, Sharokh F

AU - Gallucci, Michele

AU - Suardi, Nazareno

AU - Chun, Felix K H

AU - Tilki, Derya

AU - Graefen, Markus

AU - Karakiewicz, Pierre I

N1 - © 2022. The Author(s).

PY - 2022/5

Y1 - 2022/5

N2 - PURPOSE: To test the association between external beam radiotherapy (EBRT) after radical prostatectomy (RP) vs RP only on rates of other-cause mortality (OCM) in men with prostate cancer (PCa).PATIENTS AND METHODS: Within the 2004-2016 Surveillance, Epidemiology, and End Results database, we identified 181,849 localized PCa patients, of whom 168,041 received RP only vs 13,808 who received RP + EBRT. Cumulative incidence plots displayed OCM between RP vs RP + EBRT after propensity score matching for age, PSA, clinical T- and N-stages, and biopsy Gleason scores. Multivariable competing risks regression models addressed OCM, accounting prostate cancer-specific mortality (CSM) as a competing event. Stratifications were made according to low- vs intermediate- vs high-risk groups and additionally according to age groups of ≤ 60, 61-70, and ≥ 71 years, within each risk group.RESULTS: In low-, intermediate-, and high-risk patients, RP + EBRT rates were 2.7, 5.4 and 17.0%, respectively. After matching, 10-year OCM rates between RP and RP + EBRT were 7.7 vs 16.2% in low-, 9.4 vs 13.6% in intermediate-, and 11.4 vs 13.5% in high-risk patients (all p < 0.001), which, respectively, resulted in multivariable HR of 2.1, 1.3, and 1.2 (all p < 0.001). In subgroup analyses, excess OCM was recorded in low-risk RP + EBRT patients of all age groups (all p ≤ 0.03), but only in the older age group in intermediate-risk patients (61-70 years, p = 0.03) and finally, only in the oldest age group in high-risk patients (≥ 71 years, p = 0.02).CONCLUSION: Excess OCM was recorded in patients exposed to RT after RP. Its extent was most pronounced in low-risk patients, decreased in intermediate-risk patients, and was lowest in high-risk patients.

AB - PURPOSE: To test the association between external beam radiotherapy (EBRT) after radical prostatectomy (RP) vs RP only on rates of other-cause mortality (OCM) in men with prostate cancer (PCa).PATIENTS AND METHODS: Within the 2004-2016 Surveillance, Epidemiology, and End Results database, we identified 181,849 localized PCa patients, of whom 168,041 received RP only vs 13,808 who received RP + EBRT. Cumulative incidence plots displayed OCM between RP vs RP + EBRT after propensity score matching for age, PSA, clinical T- and N-stages, and biopsy Gleason scores. Multivariable competing risks regression models addressed OCM, accounting prostate cancer-specific mortality (CSM) as a competing event. Stratifications were made according to low- vs intermediate- vs high-risk groups and additionally according to age groups of ≤ 60, 61-70, and ≥ 71 years, within each risk group.RESULTS: In low-, intermediate-, and high-risk patients, RP + EBRT rates were 2.7, 5.4 and 17.0%, respectively. After matching, 10-year OCM rates between RP and RP + EBRT were 7.7 vs 16.2% in low-, 9.4 vs 13.6% in intermediate-, and 11.4 vs 13.5% in high-risk patients (all p < 0.001), which, respectively, resulted in multivariable HR of 2.1, 1.3, and 1.2 (all p < 0.001). In subgroup analyses, excess OCM was recorded in low-risk RP + EBRT patients of all age groups (all p ≤ 0.03), but only in the older age group in intermediate-risk patients (61-70 years, p = 0.03) and finally, only in the oldest age group in high-risk patients (≥ 71 years, p = 0.02).CONCLUSION: Excess OCM was recorded in patients exposed to RT after RP. Its extent was most pronounced in low-risk patients, decreased in intermediate-risk patients, and was lowest in high-risk patients.

KW - Aged

KW - Humans

KW - Male

KW - Neoplasm Grading

KW - Prostate

KW - Prostatectomy/methods

KW - Prostatic Neoplasms/radiotherapy

KW - Treatment Outcome

U2 - 10.1007/s10552-022-01564-z

DO - 10.1007/s10552-022-01564-z

M3 - SCORING: Journal article

C2 - 35230576

VL - 33

SP - 769

EP - 777

JO - CANCER CAUSE CONTROL

JF - CANCER CAUSE CONTROL

SN - 0957-5243

IS - 5

ER -