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Quantification of prenatal liver and spleen iron in a sheep model and assessment of iron stores in a human neonate with neonatal hemochromatosis using R2* mapping

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Quantification of prenatal liver and spleen iron in a sheep model and assessment of iron stores in a human neonate with neonatal hemochromatosis using R2* mapping. / Schoennagel, Bjoern P; Remus, Chressen C; Wedegärtner, Ulrike; Salzmann, Ina; Grabhorn, Enke; Adam, Gerhard; Fischer, Roland; Harmatz, Paul; Kooijman, Hendrik; Yamamura, Jin.

In: MAGN RESON MED, Vol. 13, No. 3, 01.01.2014, p. 167-173.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schoennagel, BP, Remus, CC, Wedegärtner, U, Salzmann, I, Grabhorn, E, Adam, G, Fischer, R, Harmatz, P, Kooijman, H & Yamamura, J 2014, 'Quantification of prenatal liver and spleen iron in a sheep model and assessment of iron stores in a human neonate with neonatal hemochromatosis using R2* mapping', MAGN RESON MED, vol. 13, no. 3, pp. 167-173. https://doi.org/10.2463/mrms.2013-0096

APA

Schoennagel, B. P., Remus, C. C., Wedegärtner, U., Salzmann, I., Grabhorn, E., Adam, G., Fischer, R., Harmatz, P., Kooijman, H., & Yamamura, J. (2014). Quantification of prenatal liver and spleen iron in a sheep model and assessment of iron stores in a human neonate with neonatal hemochromatosis using R2* mapping. MAGN RESON MED, 13(3), 167-173. https://doi.org/10.2463/mrms.2013-0096

Vancouver

Schoennagel BP, Remus CC, Wedegärtner U, Salzmann I, Grabhorn E, Adam G et al. Quantification of prenatal liver and spleen iron in a sheep model and assessment of iron stores in a human neonate with neonatal hemochromatosis using R2* mapping. MAGN RESON MED. 2014 Jan 1;13(3):167-173. https://doi.org/10.2463/mrms.2013-0096

Bibtex

@article{6f2348c604cb45f2a8132051b18b580f,
title = "Quantification of prenatal liver and spleen iron in a sheep model and assessment of iron stores in a human neonate with neonatal hemochromatosis using R2* mapping",
abstract = "PURPOSE: We evaluated the feasibility of prenatal quantification of liver and spleen iron by magnetic resonance imaging (MRI) gradient recalled echo (GRE) measurements of transverse relaxation time (R2*) (MRI-GRE-R2*) in a fetal sheep model and applied the method to a human neonate with suspected neonatal hemochromatosis.METHODS: We subjected 13 fetal sheep to MRI at 1.5 Tesla using a breath-triggered (ewe) multi-echo sequence to determine the transverse relaxation rate (R2*) of the liver and spleen. In the human neonate, we measured the R2* of the liver, spleen, and pancreas on the 30th postgestational day.RESULTS: The median R2* of the fetal sheep liver was 25.6 s(-1) (range 20 to 114 s(-1)) and of the spleen, 40.2 s(-1) (range 20 to 70 s(-1)), and the corresponding median iron concentration in the liver was 0.85 mg/g dry weight (d.w.) and in the spleen, 1.22 mg/gd.w.. R2* rates in the human neonate liver were elevated between 67 s(-1) (average), which corresponded with an iron concentration of 1.9 mg Fe/gd.w., and 126 s(-1) (regional maximum), which corresponded with 3.4 mg Fe/gd.w.. The average pancreatic R2* (72.4 s(-1)) was significantly above normal values, which indicated iron overload.CONCLUSION: We demonstrated the feasibility of prenatal quantification of tissue iron by fetal MRI in this sheep model and successfully quantified iron, including that in the pancreas, in a human neonate to confirm the diagnosis of neonatal hemochromatosis. Transferring the successful approach of quantifying iron in intrauterine tissue in fetal sheep to human pregnancies with suspected fetal siderosis could aid early diagnosis.",
author = "Schoennagel, {Bjoern P} and Remus, {Chressen C} and Ulrike Wedeg{\"a}rtner and Ina Salzmann and Enke Grabhorn and Gerhard Adam and Roland Fischer and Paul Harmatz and Hendrik Kooijman and Jin Yamamura",
year = "2014",
month = jan,
day = "1",
doi = "10.2463/mrms.2013-0096",
language = "English",
volume = "13",
pages = "167--173",
journal = "MAGN RESON MED",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Quantification of prenatal liver and spleen iron in a sheep model and assessment of iron stores in a human neonate with neonatal hemochromatosis using R2* mapping

AU - Schoennagel, Bjoern P

AU - Remus, Chressen C

AU - Wedegärtner, Ulrike

AU - Salzmann, Ina

AU - Grabhorn, Enke

AU - Adam, Gerhard

AU - Fischer, Roland

AU - Harmatz, Paul

AU - Kooijman, Hendrik

AU - Yamamura, Jin

PY - 2014/1/1

Y1 - 2014/1/1

N2 - PURPOSE: We evaluated the feasibility of prenatal quantification of liver and spleen iron by magnetic resonance imaging (MRI) gradient recalled echo (GRE) measurements of transverse relaxation time (R2*) (MRI-GRE-R2*) in a fetal sheep model and applied the method to a human neonate with suspected neonatal hemochromatosis.METHODS: We subjected 13 fetal sheep to MRI at 1.5 Tesla using a breath-triggered (ewe) multi-echo sequence to determine the transverse relaxation rate (R2*) of the liver and spleen. In the human neonate, we measured the R2* of the liver, spleen, and pancreas on the 30th postgestational day.RESULTS: The median R2* of the fetal sheep liver was 25.6 s(-1) (range 20 to 114 s(-1)) and of the spleen, 40.2 s(-1) (range 20 to 70 s(-1)), and the corresponding median iron concentration in the liver was 0.85 mg/g dry weight (d.w.) and in the spleen, 1.22 mg/gd.w.. R2* rates in the human neonate liver were elevated between 67 s(-1) (average), which corresponded with an iron concentration of 1.9 mg Fe/gd.w., and 126 s(-1) (regional maximum), which corresponded with 3.4 mg Fe/gd.w.. The average pancreatic R2* (72.4 s(-1)) was significantly above normal values, which indicated iron overload.CONCLUSION: We demonstrated the feasibility of prenatal quantification of tissue iron by fetal MRI in this sheep model and successfully quantified iron, including that in the pancreas, in a human neonate to confirm the diagnosis of neonatal hemochromatosis. Transferring the successful approach of quantifying iron in intrauterine tissue in fetal sheep to human pregnancies with suspected fetal siderosis could aid early diagnosis.

AB - PURPOSE: We evaluated the feasibility of prenatal quantification of liver and spleen iron by magnetic resonance imaging (MRI) gradient recalled echo (GRE) measurements of transverse relaxation time (R2*) (MRI-GRE-R2*) in a fetal sheep model and applied the method to a human neonate with suspected neonatal hemochromatosis.METHODS: We subjected 13 fetal sheep to MRI at 1.5 Tesla using a breath-triggered (ewe) multi-echo sequence to determine the transverse relaxation rate (R2*) of the liver and spleen. In the human neonate, we measured the R2* of the liver, spleen, and pancreas on the 30th postgestational day.RESULTS: The median R2* of the fetal sheep liver was 25.6 s(-1) (range 20 to 114 s(-1)) and of the spleen, 40.2 s(-1) (range 20 to 70 s(-1)), and the corresponding median iron concentration in the liver was 0.85 mg/g dry weight (d.w.) and in the spleen, 1.22 mg/gd.w.. R2* rates in the human neonate liver were elevated between 67 s(-1) (average), which corresponded with an iron concentration of 1.9 mg Fe/gd.w., and 126 s(-1) (regional maximum), which corresponded with 3.4 mg Fe/gd.w.. The average pancreatic R2* (72.4 s(-1)) was significantly above normal values, which indicated iron overload.CONCLUSION: We demonstrated the feasibility of prenatal quantification of tissue iron by fetal MRI in this sheep model and successfully quantified iron, including that in the pancreas, in a human neonate to confirm the diagnosis of neonatal hemochromatosis. Transferring the successful approach of quantifying iron in intrauterine tissue in fetal sheep to human pregnancies with suspected fetal siderosis could aid early diagnosis.

U2 - 10.2463/mrms.2013-0096

DO - 10.2463/mrms.2013-0096

M3 - SCORING: Journal article

C2 - 24990465

VL - 13

SP - 167

EP - 173

JO - MAGN RESON MED

JF - MAGN RESON MED

SN - 0740-3194

IS - 3

ER -