Quantification of mechanical ventricular dyssynchrony: direct comparison of velocity-encoded and cine magnetic resonance imaging
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Quantification of mechanical ventricular dyssynchrony: direct comparison of velocity-encoded and cine magnetic resonance imaging. / Muellerleile, K; Baholli, L; Groth, M; Koopmann, K; Barmeyer, A; Gosau, N; Ventura, R; Rostock, T; Koester, R; Adam, G; Willems, S; Lund, G.
In: ROFO-FORTSCHR RONTG, Vol. 183, No. 6, 6, 06.2011, p. 554-560.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Quantification of mechanical ventricular dyssynchrony: direct comparison of velocity-encoded and cine magnetic resonance imaging
AU - Muellerleile, K
AU - Baholli, L
AU - Groth, M
AU - Koopmann, K
AU - Barmeyer, A
AU - Gosau, N
AU - Ventura, R
AU - Rostock, T
AU - Koester, R
AU - Adam, G
AU - Willems, S
AU - Lund, G
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2011/6
Y1 - 2011/6
N2 - PURPOSE: The preoperative assessment of mechanical dyssynchrony can help to improve patient selection in candidates for cardiac resynchronization therapy (CRT). The present study compared the performance of velocity-encoded (VENC) MRI to cine-magnetic resonance imaging (MRI) for quantifying mechanical ventricular dyssynchrony.MATERIALS AND METHODS: VENC-MRI and cine-MRI were performed in 20 patients with heart failure NYHA class III and reduced ejection fraction (median: 24 %, interquartile range: 18 - 28 %) before CRT device implantation. The interventricular mechanical delay (IVMD) was assessed by VENC-MRI as the temporal difference between the onset of aortic and pulmonary flow. Intraventricular dyssynchrony was quantified by cine-MRI, using the standard deviation of time to maximal wall thickening in sixteen left ventricular segments (SDt-16). The response to CRT was assessed in a six-month follow-up.RESULTS: 14 patients (70 %) clinically responded to CRT. A similar accuracy was found to predict the response to CRT by measurements of the IVMD and SDt-16 (75 vs. 70 %; p = ns). The time needed for data analysis was significantly shorter for the IVMD at 1.69 min (interquartile range: 1.66 - 1.88 min) compared to 9.63 min (interquartile range: 8.92 - 11.63 min) for the SDt-16 (p < 0.0001).CONCLUSION: Measurements of the IVMD by VENC-MRI and the SDt-16 by cine-MRI provide a similar accuracy to identify clinical responders to CRT. However, data analysis of the IVMD is significantly less time-consuming compared to data analysis of the SDt-16.
AB - PURPOSE: The preoperative assessment of mechanical dyssynchrony can help to improve patient selection in candidates for cardiac resynchronization therapy (CRT). The present study compared the performance of velocity-encoded (VENC) MRI to cine-magnetic resonance imaging (MRI) for quantifying mechanical ventricular dyssynchrony.MATERIALS AND METHODS: VENC-MRI and cine-MRI were performed in 20 patients with heart failure NYHA class III and reduced ejection fraction (median: 24 %, interquartile range: 18 - 28 %) before CRT device implantation. The interventricular mechanical delay (IVMD) was assessed by VENC-MRI as the temporal difference between the onset of aortic and pulmonary flow. Intraventricular dyssynchrony was quantified by cine-MRI, using the standard deviation of time to maximal wall thickening in sixteen left ventricular segments (SDt-16). The response to CRT was assessed in a six-month follow-up.RESULTS: 14 patients (70 %) clinically responded to CRT. A similar accuracy was found to predict the response to CRT by measurements of the IVMD and SDt-16 (75 vs. 70 %; p = ns). The time needed for data analysis was significantly shorter for the IVMD at 1.69 min (interquartile range: 1.66 - 1.88 min) compared to 9.63 min (interquartile range: 8.92 - 11.63 min) for the SDt-16 (p < 0.0001).CONCLUSION: Measurements of the IVMD by VENC-MRI and the SDt-16 by cine-MRI provide a similar accuracy to identify clinical responders to CRT. However, data analysis of the IVMD is significantly less time-consuming compared to data analysis of the SDt-16.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Reproducibility of Results
KW - Predictive Value of Tests
KW - Time Factors
KW - Cardiac Resynchronization Therapy
KW - Heart Failure/diagnosis/pathology/therapy
KW - Magnetic Resonance Imaging/standards
KW - Magnetic Resonance Imaging, Cine/standards
KW - Statistics as Topic/standards
KW - Ventricular Dysfunction/diagnosis
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Reproducibility of Results
KW - Predictive Value of Tests
KW - Time Factors
KW - Cardiac Resynchronization Therapy
KW - Heart Failure/diagnosis/pathology/therapy
KW - Magnetic Resonance Imaging/standards
KW - Magnetic Resonance Imaging, Cine/standards
KW - Statistics as Topic/standards
KW - Ventricular Dysfunction/diagnosis
U2 - 10.1055/s-0031-1273320
DO - 10.1055/s-0031-1273320
M3 - SCORING: Journal article
C2 - 21487982
VL - 183
SP - 554
EP - 560
JO - ROFO-FORTSCHR RONTG
JF - ROFO-FORTSCHR RONTG
SN - 1438-9029
IS - 6
M1 - 6
ER -
