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Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies

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Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies. / Steinbach, Silke; Hummel, Thomas; Böhner, Christina; Berktold, Sabina; Hundt, Walter; Kriner, Monika; Heinrich, Petra; Sommer, Harald; Hanusch, Claus; Prechtl, Anita; Schmidt, Burghart; Bauerfeind, Ingo; Seck, Katharina; Jacobs, Volker R; Schmalfeldt, Barbara; Harbeck, Nadia.

In: J CLIN ONCOL, Vol. 27, No. 11, 10.04.2009, p. 1899-905.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Steinbach, S, Hummel, T, Böhner, C, Berktold, S, Hundt, W, Kriner, M, Heinrich, P, Sommer, H, Hanusch, C, Prechtl, A, Schmidt, B, Bauerfeind, I, Seck, K, Jacobs, VR, Schmalfeldt, B & Harbeck, N 2009, 'Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies', J CLIN ONCOL, vol. 27, no. 11, pp. 1899-905. https://doi.org/10.1200/JCO.2008.19.2690

APA

Steinbach, S., Hummel, T., Böhner, C., Berktold, S., Hundt, W., Kriner, M., Heinrich, P., Sommer, H., Hanusch, C., Prechtl, A., Schmidt, B., Bauerfeind, I., Seck, K., Jacobs, V. R., Schmalfeldt, B., & Harbeck, N. (2009). Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies. J CLIN ONCOL, 27(11), 1899-905. https://doi.org/10.1200/JCO.2008.19.2690

Vancouver

Steinbach S, Hummel T, Böhner C, Berktold S, Hundt W, Kriner M et al. Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies. J CLIN ONCOL. 2009 Apr 10;27(11):1899-905. https://doi.org/10.1200/JCO.2008.19.2690

Bibtex

@article{c1932df639ee47a1b1c66c4ab8181927,
title = "Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies",
abstract = "PURPOSE: Smell and taste changes during chemotherapy are significant complaints of cancer patients. Loss of olfactory/gustatory function can lead to malnutrition, weight loss, and possibly a prolonged morbidity of chemotherapy-induced adverse effects, decreased quality of life, poor compliance, and even decreased therapy response. This prospective study comprehensively investigated, to our knowledge for the first time, smell and taste changes in a cohort of 87 patients undergoing chemotherapy for breast cancer or gynecologic malignancies.PATIENTS AND METHODS: Olfactory function was tested using Sniffin' Sticks (Burghart; Wedel, Germany) and gustatory function was tested using taste strips before, during, and immediately and 3 months after chemotherapy.RESULTS: Olfactory and gustatory function significantly decreased during chemotherapy and recovered almost completely 3 months after chemotherapy. Scores of odor thresholds were affected more than those of discrimination or identification. The olfactory function of older patients was affected more than that of younger patients. There was no difference in the olfactory function during chemotherapy with respect to the chemotherapeutic agent or initial diagnosis (breast or ovarian cancer). Regarding taste, scores of salty taste were affected more than scores of sweet, sour, or bitter taste. The gustatory function did not differ significantly during chemotherapy with respect to age or diagnosis but did differ with respect to the chemotherapeutic agent. Taxane-based chemotherapy caused the most severe disorders.CONCLUSION: Chemotherapy has a significant but transient effect on olfactory and gustatory function, possibly causing reduced appetite, a low energy intake, and weight loss. Additional spices and flavoring may compensate for this diminished chemosensory function, enhancing patient compliance and quality of life.",
keywords = "Adult, Aged, Antineoplastic Agents, Breast Neoplasms, Female, Genital Neoplasms, Female, Humans, Middle Aged, Olfaction Disorders, Prospective Studies, Taste Disorders, Young Adult",
author = "Silke Steinbach and Thomas Hummel and Christina B{\"o}hner and Sabina Berktold and Walter Hundt and Monika Kriner and Petra Heinrich and Harald Sommer and Claus Hanusch and Anita Prechtl and Burghart Schmidt and Ingo Bauerfeind and Katharina Seck and Jacobs, {Volker R} and Barbara Schmalfeldt and Nadia Harbeck",
year = "2009",
month = apr,
day = "10",
doi = "10.1200/JCO.2008.19.2690",
language = "English",
volume = "27",
pages = "1899--905",
journal = "J CLIN ONCOL",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "11",

}

RIS

TY - JOUR

T1 - Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies

AU - Steinbach, Silke

AU - Hummel, Thomas

AU - Böhner, Christina

AU - Berktold, Sabina

AU - Hundt, Walter

AU - Kriner, Monika

AU - Heinrich, Petra

AU - Sommer, Harald

AU - Hanusch, Claus

AU - Prechtl, Anita

AU - Schmidt, Burghart

AU - Bauerfeind, Ingo

AU - Seck, Katharina

AU - Jacobs, Volker R

AU - Schmalfeldt, Barbara

AU - Harbeck, Nadia

PY - 2009/4/10

Y1 - 2009/4/10

N2 - PURPOSE: Smell and taste changes during chemotherapy are significant complaints of cancer patients. Loss of olfactory/gustatory function can lead to malnutrition, weight loss, and possibly a prolonged morbidity of chemotherapy-induced adverse effects, decreased quality of life, poor compliance, and even decreased therapy response. This prospective study comprehensively investigated, to our knowledge for the first time, smell and taste changes in a cohort of 87 patients undergoing chemotherapy for breast cancer or gynecologic malignancies.PATIENTS AND METHODS: Olfactory function was tested using Sniffin' Sticks (Burghart; Wedel, Germany) and gustatory function was tested using taste strips before, during, and immediately and 3 months after chemotherapy.RESULTS: Olfactory and gustatory function significantly decreased during chemotherapy and recovered almost completely 3 months after chemotherapy. Scores of odor thresholds were affected more than those of discrimination or identification. The olfactory function of older patients was affected more than that of younger patients. There was no difference in the olfactory function during chemotherapy with respect to the chemotherapeutic agent or initial diagnosis (breast or ovarian cancer). Regarding taste, scores of salty taste were affected more than scores of sweet, sour, or bitter taste. The gustatory function did not differ significantly during chemotherapy with respect to age or diagnosis but did differ with respect to the chemotherapeutic agent. Taxane-based chemotherapy caused the most severe disorders.CONCLUSION: Chemotherapy has a significant but transient effect on olfactory and gustatory function, possibly causing reduced appetite, a low energy intake, and weight loss. Additional spices and flavoring may compensate for this diminished chemosensory function, enhancing patient compliance and quality of life.

AB - PURPOSE: Smell and taste changes during chemotherapy are significant complaints of cancer patients. Loss of olfactory/gustatory function can lead to malnutrition, weight loss, and possibly a prolonged morbidity of chemotherapy-induced adverse effects, decreased quality of life, poor compliance, and even decreased therapy response. This prospective study comprehensively investigated, to our knowledge for the first time, smell and taste changes in a cohort of 87 patients undergoing chemotherapy for breast cancer or gynecologic malignancies.PATIENTS AND METHODS: Olfactory function was tested using Sniffin' Sticks (Burghart; Wedel, Germany) and gustatory function was tested using taste strips before, during, and immediately and 3 months after chemotherapy.RESULTS: Olfactory and gustatory function significantly decreased during chemotherapy and recovered almost completely 3 months after chemotherapy. Scores of odor thresholds were affected more than those of discrimination or identification. The olfactory function of older patients was affected more than that of younger patients. There was no difference in the olfactory function during chemotherapy with respect to the chemotherapeutic agent or initial diagnosis (breast or ovarian cancer). Regarding taste, scores of salty taste were affected more than scores of sweet, sour, or bitter taste. The gustatory function did not differ significantly during chemotherapy with respect to age or diagnosis but did differ with respect to the chemotherapeutic agent. Taxane-based chemotherapy caused the most severe disorders.CONCLUSION: Chemotherapy has a significant but transient effect on olfactory and gustatory function, possibly causing reduced appetite, a low energy intake, and weight loss. Additional spices and flavoring may compensate for this diminished chemosensory function, enhancing patient compliance and quality of life.

KW - Adult

KW - Aged

KW - Antineoplastic Agents

KW - Breast Neoplasms

KW - Female

KW - Genital Neoplasms, Female

KW - Humans

KW - Middle Aged

KW - Olfaction Disorders

KW - Prospective Studies

KW - Taste Disorders

KW - Young Adult

U2 - 10.1200/JCO.2008.19.2690

DO - 10.1200/JCO.2008.19.2690

M3 - SCORING: Journal article

C2 - 19289621

VL - 27

SP - 1899

EP - 1905

JO - J CLIN ONCOL

JF - J CLIN ONCOL

SN - 0732-183X

IS - 11

ER -