Psychosocial Stress and Brain Function in Adolescent Psychopathology
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Psychosocial Stress and Brain Function in Adolescent Psychopathology. / Quinlan, Erin Burke; Cattrell, Anna; Jia, Tianye; Artiges, Eric; Banaschewski, Tobias; Barker, Gareth; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Brühl, Rüdiger; Conrod, Patricia J; Desrivieres, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Nees, Frauke; Papadopoulos-Orfanos, Dimitri; Paus, Tomáš; Poustka, Luise; Smolka, Michael N; Vetter, Nora C; Walter, Henrik; Whelan, Robert; Glennon, Jeffrey C; Buitelaar, Jan K; Happé, Francesca; Loth, Eva; Barker, Edward D; Schumann, Gunter; IMAGEN Consortium.
In: AM J PSYCHIAT, Vol. 174, No. 8, 01.08.2017, p. 785-794.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Psychosocial Stress and Brain Function in Adolescent Psychopathology
AU - Quinlan, Erin Burke
AU - Cattrell, Anna
AU - Jia, Tianye
AU - Artiges, Eric
AU - Banaschewski, Tobias
AU - Barker, Gareth
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Brühl, Rüdiger
AU - Conrod, Patricia J
AU - Desrivieres, Sylvane
AU - Flor, Herta
AU - Frouin, Vincent
AU - Gallinat, Jürgen
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Martinot, Jean-Luc
AU - Paillère Martinot, Marie-Laure
AU - Nees, Frauke
AU - Papadopoulos-Orfanos, Dimitri
AU - Paus, Tomáš
AU - Poustka, Luise
AU - Smolka, Michael N
AU - Vetter, Nora C
AU - Walter, Henrik
AU - Whelan, Robert
AU - Glennon, Jeffrey C
AU - Buitelaar, Jan K
AU - Happé, Francesca
AU - Loth, Eva
AU - Barker, Edward D
AU - Schumann, Gunter
AU - IMAGEN Consortium
PY - 2017/8/1
Y1 - 2017/8/1
N2 - OBJECTIVE: The authors sought to explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships.METHOD: Participants were community adolescents recruited as part of the European IMAGEN study. Bilateral amygdala regions of interest were used to assess the relationship between the three symptom domains and functional MRI neural reactivity during passive viewing of dynamic angry and neutral facial expressions. Exploratory functional connectivity and whole brain multiple regression approaches were used to analyze how the symptoms and psychosocial stress relate to other brain regions.RESULTS: In response to the social-emotional stimuli, adolescents with high levels of conduct or hyperactivity/inattention symptoms who had also experienced a greater number of stressful life events showed hyperactivity of the amygdala and several regions across the brain. This effect was not observed with emotional symptoms. A cluster in the midcingulate was found to be common to both conduct problems and hyperactivity symptoms. Exploratory functional connectivity analyses suggested that amygdala-precuneus connectivity is associated with hyperactivity/inattention symptoms.CONCLUSIONS: The results link hyperactive amygdala responses and regions critical for top-down emotional processing with high levels of psychosocial stress in individuals with greater conduct and hyperactivity/inattention symptoms. This work highlights the importance of studying how psychosocial stress affects functional brain responses to social-emotional stimuli, particularly in adolescents with externalizing symptoms.
AB - OBJECTIVE: The authors sought to explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships.METHOD: Participants were community adolescents recruited as part of the European IMAGEN study. Bilateral amygdala regions of interest were used to assess the relationship between the three symptom domains and functional MRI neural reactivity during passive viewing of dynamic angry and neutral facial expressions. Exploratory functional connectivity and whole brain multiple regression approaches were used to analyze how the symptoms and psychosocial stress relate to other brain regions.RESULTS: In response to the social-emotional stimuli, adolescents with high levels of conduct or hyperactivity/inattention symptoms who had also experienced a greater number of stressful life events showed hyperactivity of the amygdala and several regions across the brain. This effect was not observed with emotional symptoms. A cluster in the midcingulate was found to be common to both conduct problems and hyperactivity symptoms. Exploratory functional connectivity analyses suggested that amygdala-precuneus connectivity is associated with hyperactivity/inattention symptoms.CONCLUSIONS: The results link hyperactive amygdala responses and regions critical for top-down emotional processing with high levels of psychosocial stress in individuals with greater conduct and hyperactivity/inattention symptoms. This work highlights the importance of studying how psychosocial stress affects functional brain responses to social-emotional stimuli, particularly in adolescents with externalizing symptoms.
KW - Adolescent
KW - Amygdala
KW - Attention Deficit Disorder with Hyperactivity
KW - Brain
KW - Conduct Disorder
KW - Emotions
KW - Facial Expression
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Neural Pathways
KW - Parietal Lobe
KW - Pattern Recognition, Visual
KW - Social Environment
KW - Stress, Psychological
KW - Journal Article
U2 - 10.1176/appi.ajp.2017.16040464
DO - 10.1176/appi.ajp.2017.16040464
M3 - SCORING: Journal article
C2 - 28618856
VL - 174
SP - 785
EP - 794
JO - AM J PSYCHIAT
JF - AM J PSYCHIAT
SN - 0002-953X
IS - 8
ER -
