Living renal donation is of benefit to the allograft recipient. Careful analysis of the donor outcome is necessary with respect to the medical condition, socioeconomic status, and health-related quality of life. All living kidney donors of the Transplant Center at Heidelberg were included. Renal function and comorbidities were assessed. HRQoL and fatigue symptoms were determined by self-reporting validated test systems [Short-Form 36 (SF-36), Multidimensional Fatigue Inventory (MFI-20), Patient Health Questionnaire (PHQ)]. In total, 430 of 519 living renal donors were eligible to participate: 295 living donors (68.6%) provided informed consent (age at donation 49 ± 11 years) with a median time after donation of 77 (24-484) months. Renal function was lower compared with predonation (66 ± 15 ml/min vs. 88 ± 14 ml/min). Blood pressure remained stable (128 ± 14 mmHg vs. 129 ± 15 mmHg) with an increase of 56 donors receiving antihypertensive treatment (27.1% vs. 19%). The SF-36 physical component summary score was significantly better for both genders compared with the general population; the SF-36 mental component summary score was lower for female donors, caused by a reduced role functioning. Prevalence of fatigue was increased in female donors between the ages of 40 and 59 years. Renal function and blood pressure were as expected from previous studies. Concerning the psychosocial outcome, female donors might be at risk of impairments postdonation. Future evaluations will confirm and specify whether these results are necessary.
