Psychopathological characteristics and treatment response of first episode compared with multiple episode schizophrenic disorders.
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Psychopathological characteristics and treatment response of first episode compared with multiple episode schizophrenic disorders. / Jäger, Markus; Riedel, Michael; Messer, Thomas; Laux, Gerd; Pfeiffer, Herbert; Naber, Dieter; Schmidt, Lutz G; Gaebel, Wolfgang; Huff, Wolfgang; Heuser, Isabella; Kühn, Kai-Uwe; Lemke, Matthias R; Rüther, Eckart; Buchkremer, Gerhard; Gastpar, Markus; Bottlender, Ronald; Strauss, Anton; Möller, Hans-Jürgen.
In: EUR ARCH PSY CLIN N, Vol. 257, No. 1, 1, 2007, p. 47-53.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Psychopathological characteristics and treatment response of first episode compared with multiple episode schizophrenic disorders.
AU - Jäger, Markus
AU - Riedel, Michael
AU - Messer, Thomas
AU - Laux, Gerd
AU - Pfeiffer, Herbert
AU - Naber, Dieter
AU - Schmidt, Lutz G
AU - Gaebel, Wolfgang
AU - Huff, Wolfgang
AU - Heuser, Isabella
AU - Kühn, Kai-Uwe
AU - Lemke, Matthias R
AU - Rüther, Eckart
AU - Buchkremer, Gerhard
AU - Gastpar, Markus
AU - Bottlender, Ronald
AU - Strauss, Anton
AU - Möller, Hans-Jürgen
PY - 2007
Y1 - 2007
N2 - OBJECTIVE: The aim was to investigate the hypothesis that patients with first episode schizophrenic disorders have a more favorable treatment response than those with multiple episodes. METHOD: A total of 400 inpatients from an ongoing multi-centre, follow-up program who fulfilled ICD-10 criteria for schizophrenic disorders (F2) were assessed at admission to and discharge from hospital using the Positive and Negative Syndrome Scale (PANSS). RESULTS: At admission, first episode patients (n = 121) showed higher levels of positive symptoms (PANSS positive subscore) and lower ones of negative symptoms (PANSS negative subscore) than multiple episode patients (n = 279), whereas the global disease severity (PANSS total score) was comparable. Analyses of covariance revealed that treatment response (adjusted symptom levels at discharge) was more favorable in first-episode patients, with respect to both positive and negative symptoms. CONCLUSION: The results are compatible with the hypothesis that treatment response becomes less favorable during the course of schizophrenic illness. This finding might be associated with progressive neurobiological alterations.
AB - OBJECTIVE: The aim was to investigate the hypothesis that patients with first episode schizophrenic disorders have a more favorable treatment response than those with multiple episodes. METHOD: A total of 400 inpatients from an ongoing multi-centre, follow-up program who fulfilled ICD-10 criteria for schizophrenic disorders (F2) were assessed at admission to and discharge from hospital using the Positive and Negative Syndrome Scale (PANSS). RESULTS: At admission, first episode patients (n = 121) showed higher levels of positive symptoms (PANSS positive subscore) and lower ones of negative symptoms (PANSS negative subscore) than multiple episode patients (n = 279), whereas the global disease severity (PANSS total score) was comparable. Analyses of covariance revealed that treatment response (adjusted symptom levels at discharge) was more favorable in first-episode patients, with respect to both positive and negative symptoms. CONCLUSION: The results are compatible with the hypothesis that treatment response becomes less favorable during the course of schizophrenic illness. This finding might be associated with progressive neurobiological alterations.
M3 - SCORING: Zeitschriftenaufsatz
VL - 257
SP - 47
EP - 53
JO - EUR ARCH PSY CLIN N
JF - EUR ARCH PSY CLIN N
SN - 0940-1334
IS - 1
M1 - 1
ER -
