Psychological Outcome, Fatigue, and Quality of Life After Infection With Shiga Toxin-Producing Escherichia coli O104
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Psychological Outcome, Fatigue, and Quality of Life After Infection With Shiga Toxin-Producing Escherichia coli O104. / Löwe, Bernd; Andresen, Viola; Zimmermann-Fraedrich, Katharina; Gappmayer, Kerrin; Wegscheider, Karl; Treszl, András; Riegel, Björn; Rose, Matthias; Lohse, Ansgar W; Broicher, Wiebke.
In: CLIN GASTROENTEROL H, 13.03.2014.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Psychological Outcome, Fatigue, and Quality of Life After Infection With Shiga Toxin-Producing Escherichia coli O104
AU - Löwe, Bernd
AU - Andresen, Viola
AU - Zimmermann-Fraedrich, Katharina
AU - Gappmayer, Kerrin
AU - Wegscheider, Karl
AU - Treszl, András
AU - Riegel, Björn
AU - Rose, Matthias
AU - Lohse, Ansgar W
AU - Broicher, Wiebke
N1 - Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.
PY - 2014/3/13
Y1 - 2014/3/13
N2 - BACKGROUND & AIMS: From May through July 2011 in northern Germany, there was a large outbreak of hemolytic uremic syndrome and bloody diarrhea, which was related to infections from Shiga toxin-producing Escherichia coli O104 (STEC). We investigated the depression, posttraumatic symptoms, fatigue, and health-related quality of life among patients within the first 6 months after STEC infection and aimed to identify factors associated with poor outcome.METHODS: In a cohort study, we performed baseline assessments of 389 patients (69% female) 3 months after STEC infection (82 ± 36 days) and follow-up assessments of 308 of the patients 6 months afterward (199 ± 17 days). Data were collected at 13 hospitals in northern Germany. Patients completed validated self-report scales and a diagnostic interview.RESULTS: At baseline, hemolytic uremic syndrome was diagnosed in 31% of the patients. Six months after the infection, mean self-reported severity of depression and posttraumatic symptoms and fatigue were significantly greater than in the general population, and the mean score from the mental component of health-related quality of life survey was significantly lower than average. Posttraumatic stress disorder had recently developed in 3% of patients (95% confidence interval, 1%-5%), and 43% of patients had clinically relevant fatigue (95% confidence interval, 41%-45%). The most important baseline factors associated with poor psychological health 6 months after STEC infection were previous traumatic events, neuroticism, and low social support (all P < .05).CONCLUSIONS: Six months after the major outbreak of STEC infection in northern Germany, a substantial number of patients had poor psychological health, persistent fatigue, and impaired quality of life. For future outbreaks, patients' premorbid risk factors should be considered, which might minimize the long-term effects of infections on mental health.
AB - BACKGROUND & AIMS: From May through July 2011 in northern Germany, there was a large outbreak of hemolytic uremic syndrome and bloody diarrhea, which was related to infections from Shiga toxin-producing Escherichia coli O104 (STEC). We investigated the depression, posttraumatic symptoms, fatigue, and health-related quality of life among patients within the first 6 months after STEC infection and aimed to identify factors associated with poor outcome.METHODS: In a cohort study, we performed baseline assessments of 389 patients (69% female) 3 months after STEC infection (82 ± 36 days) and follow-up assessments of 308 of the patients 6 months afterward (199 ± 17 days). Data were collected at 13 hospitals in northern Germany. Patients completed validated self-report scales and a diagnostic interview.RESULTS: At baseline, hemolytic uremic syndrome was diagnosed in 31% of the patients. Six months after the infection, mean self-reported severity of depression and posttraumatic symptoms and fatigue were significantly greater than in the general population, and the mean score from the mental component of health-related quality of life survey was significantly lower than average. Posttraumatic stress disorder had recently developed in 3% of patients (95% confidence interval, 1%-5%), and 43% of patients had clinically relevant fatigue (95% confidence interval, 41%-45%). The most important baseline factors associated with poor psychological health 6 months after STEC infection were previous traumatic events, neuroticism, and low social support (all P < .05).CONCLUSIONS: Six months after the major outbreak of STEC infection in northern Germany, a substantial number of patients had poor psychological health, persistent fatigue, and impaired quality of life. For future outbreaks, patients' premorbid risk factors should be considered, which might minimize the long-term effects of infections on mental health.
U2 - 10.1016/j.cgh.2014.02.035
DO - 10.1016/j.cgh.2014.02.035
M3 - SCORING: Journal article
C2 - 24632347
JO - CLIN GASTROENTEROL H
JF - CLIN GASTROENTEROL H
SN - 1542-3565
ER -