Psychological burden associated with incident persistent symptoms and their evolution during the COVID-19 pandemic: a prospective population-based study
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Psychological burden associated with incident persistent symptoms and their evolution during the COVID-19 pandemic: a prospective population-based study. / Pignon, Baptiste; Matta, Joane; Wiernik, Emmanuel; Toussaint, Anne-Kristin; Löwe, Bernd; Robineau, Olivier; Carrat, Fabrice; Severi, Gianluca; Touvier, Mathilde; Gouraud, Clément; Ouazana-Vedrines, Charles; Pitron, Victor; Ranque, Brigitte; Hoertel, Nicolas; Kab, Sofiane; Goldberg, Marcel; Zins, Marie; Lemogne, Cédric.
In: BMJ Mental Health, Vol. 27, No. 1, e300907, 15.03.2024.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Psychological burden associated with incident persistent symptoms and their evolution during the COVID-19 pandemic: a prospective population-based study
AU - Pignon, Baptiste
AU - Matta, Joane
AU - Wiernik, Emmanuel
AU - Toussaint, Anne-Kristin
AU - Löwe, Bernd
AU - Robineau, Olivier
AU - Carrat, Fabrice
AU - Severi, Gianluca
AU - Touvier, Mathilde
AU - Gouraud, Clément
AU - Ouazana-Vedrines, Charles
AU - Pitron, Victor
AU - Ranque, Brigitte
AU - Hoertel, Nicolas
AU - Kab, Sofiane
AU - Goldberg, Marcel
AU - Zins, Marie
AU - Lemogne, Cédric
PY - 2024/3/15
Y1 - 2024/3/15
N2 - Background Identifying factors that predict the course of persistent symptoms that occurred during the COVID-19 pandemic is a public health issue. Modifiable factors could be targeted in therapeutic interventions.Objective This prospective study based on the population-based CONSTANCES cohort examined whether the psychological burden associated with incident persistent symptoms (ie, that first occurred from March 2020) would predict having ≥1 persistent symptom 6–10 months later.Methods A total of 8424 participants (mean age=54.6 years (SD=12.6), 57.2% women) having ≥1 incident persistent symptom at baseline (ie, between December 2020 and February 2021) were included. The psychological burden associated with these persistent symptoms was assessed with the Somatic Symptom Disorder-B Criteria Scale (SSD-12). The outcome was having ≥1 persistent symptom at follow-up. Adjusted binary logistic regression models examined the association between the SSD-12 score and the outcome.Findings At follow-up, 1124 participants (13.3%) still had ≥1 persistent symptom. The SSD-12 score at baseline was associated with persistent symptoms at follow-up in both participants with (OR (95% CI) for one IQR increase: 1.42 (1.09 to 1.84)) and without SARS-CoV-2 infection prior to baseline (1.39 (1.25 to 1.55)). Female gender, older age, poorer self-rated health and infection prior to baseline were also associated with persistent symptoms at follow-up.Conclusions The psychological burden associated with persistent symptoms at baseline predicted the presence of ≥1 persistent symptom at follow-up regardless of infection prior to baseline.Clinical implications Intervention studies should test whether reducing the psychological burden associated with persistent symptoms could improve the course of these symptoms.
AB - Background Identifying factors that predict the course of persistent symptoms that occurred during the COVID-19 pandemic is a public health issue. Modifiable factors could be targeted in therapeutic interventions.Objective This prospective study based on the population-based CONSTANCES cohort examined whether the psychological burden associated with incident persistent symptoms (ie, that first occurred from March 2020) would predict having ≥1 persistent symptom 6–10 months later.Methods A total of 8424 participants (mean age=54.6 years (SD=12.6), 57.2% women) having ≥1 incident persistent symptom at baseline (ie, between December 2020 and February 2021) were included. The psychological burden associated with these persistent symptoms was assessed with the Somatic Symptom Disorder-B Criteria Scale (SSD-12). The outcome was having ≥1 persistent symptom at follow-up. Adjusted binary logistic regression models examined the association between the SSD-12 score and the outcome.Findings At follow-up, 1124 participants (13.3%) still had ≥1 persistent symptom. The SSD-12 score at baseline was associated with persistent symptoms at follow-up in both participants with (OR (95% CI) for one IQR increase: 1.42 (1.09 to 1.84)) and without SARS-CoV-2 infection prior to baseline (1.39 (1.25 to 1.55)). Female gender, older age, poorer self-rated health and infection prior to baseline were also associated with persistent symptoms at follow-up.Conclusions The psychological burden associated with persistent symptoms at baseline predicted the presence of ≥1 persistent symptom at follow-up regardless of infection prior to baseline.Clinical implications Intervention studies should test whether reducing the psychological burden associated with persistent symptoms could improve the course of these symptoms.
U2 - 10.1136/bmjment-2023-300907
DO - 10.1136/bmjment-2023-300907
M3 - SCORING: Journal article
C2 - 38490690
VL - 27
JO - BMJ Mental Health
JF - BMJ Mental Health
SN - 2755-9734
IS - 1
M1 - e300907
ER -
