Psychological and hormonal features of smokers at risk to gain weight after smoking cessation--results of a multicenter study.
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Psychological and hormonal features of smokers at risk to gain weight after smoking cessation--results of a multicenter study. / Koopmann, Anne; Dinter, Christina; Grosshans, Martin; von der Goltz, Christoph; Hentschel, Rahel; Dahmen, Norbert; Gallinat, Jürgen; Wagner, Michael; Gründer, Gerd; Thürauf, Norbert; Wienker, Thomas; Brinkmeyer, Jürgen; Mobascher, Arian; Spreckelmeyer, Katja N; Clepce, Marion; de Millas, Walter; Wiedemann, Klaus; Winterer, Georg; Kiefer, Falk.
In: HORM BEHAV, Vol. 60, No. 1, 1, 2011, p. 58-64.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Psychological and hormonal features of smokers at risk to gain weight after smoking cessation--results of a multicenter study.
AU - Koopmann, Anne
AU - Dinter, Christina
AU - Grosshans, Martin
AU - von der Goltz, Christoph
AU - Hentschel, Rahel
AU - Dahmen, Norbert
AU - Gallinat, Jürgen
AU - Wagner, Michael
AU - Gründer, Gerd
AU - Thürauf, Norbert
AU - Wienker, Thomas
AU - Brinkmeyer, Jürgen
AU - Mobascher, Arian
AU - Spreckelmeyer, Katja N
AU - Clepce, Marion
AU - de Millas, Walter
AU - Wiedemann, Klaus
AU - Winterer, Georg
AU - Kiefer, Falk
PY - 2011
Y1 - 2011
N2 - Preclinical and clinical data suggest modulating effects of appetite-regulating hormones and stress perception on food intake. Nicotine intake also interferes with regulation of body weight. Especially following smoking cessation gaining weight is a common but only partially understood consequence. The aim of this study was to examine the interaction between smoking habits, the appetite regulating hormone leptin, negative affectivity, and stress vulnerability on eating behavior in a clinical case-control study under standardized conditions. In a large population-based study sample, we compared leptin and cortisol plasma concentrations (radioimmunoassay) between current tobacco smokers with high cognitive restraint and disinhibition in eating behavior and smokers scoring low in both categories as assessed with the Three Factor Eating Questionnaire (TFEQ; Stunkard & Messick, 1985). As a measure for smoking effects on the stress axis, the saliva cortisol concentrations were compared before and after nicotine smoking. Additionally, stress perception was assessed with the Perceived Stress Scale (PSS), symptoms of depression and anxiety with the Beck Depression Inventory (BDI) and the State Trait Anxiety Inventory (STAI). In smokers showing high cognitive restraint and disinhibition we found significantly higher leptin concentrations than in the group of smokers scoring low in both categories. Furthermore there was a significant group difference in saliva cortisol concentrations after nicotine intake. Smokers showing high cognitive restraint and disinhibition were also characterized by significantly higher scores in the STAI, the PSS and the BDI. Our results suggest that smokers with a pathological eating behavior show an impaired neuroendocrine regulation of appetite and are prone to experience higher levels of stress and negative affectivity. This interaction of behavioral and neuroendocrinological factors may constitute a high risk condition for gaining weight following smoking cessation.
AB - Preclinical and clinical data suggest modulating effects of appetite-regulating hormones and stress perception on food intake. Nicotine intake also interferes with regulation of body weight. Especially following smoking cessation gaining weight is a common but only partially understood consequence. The aim of this study was to examine the interaction between smoking habits, the appetite regulating hormone leptin, negative affectivity, and stress vulnerability on eating behavior in a clinical case-control study under standardized conditions. In a large population-based study sample, we compared leptin and cortisol plasma concentrations (radioimmunoassay) between current tobacco smokers with high cognitive restraint and disinhibition in eating behavior and smokers scoring low in both categories as assessed with the Three Factor Eating Questionnaire (TFEQ; Stunkard & Messick, 1985). As a measure for smoking effects on the stress axis, the saliva cortisol concentrations were compared before and after nicotine smoking. Additionally, stress perception was assessed with the Perceived Stress Scale (PSS), symptoms of depression and anxiety with the Beck Depression Inventory (BDI) and the State Trait Anxiety Inventory (STAI). In smokers showing high cognitive restraint and disinhibition we found significantly higher leptin concentrations than in the group of smokers scoring low in both categories. Furthermore there was a significant group difference in saliva cortisol concentrations after nicotine intake. Smokers showing high cognitive restraint and disinhibition were also characterized by significantly higher scores in the STAI, the PSS and the BDI. Our results suggest that smokers with a pathological eating behavior show an impaired neuroendocrine regulation of appetite and are prone to experience higher levels of stress and negative affectivity. This interaction of behavioral and neuroendocrinological factors may constitute a high risk condition for gaining weight following smoking cessation.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Questionnaires
KW - Young Adult
KW - Case-Control Studies
KW - Risk
KW - Saliva/chemistry
KW - Anxiety/blood/epidemiology/physiopathology
KW - Feeding Behavior/physiology/psychology
KW - Hydrocortisone/blood/physiology
KW - Leptin/blood/physiology
KW - Smoking/blood/epidemiology/psychology
KW - Smoking Cessation/psychology/statistics & numerical data
KW - Stress, Psychological/epidemiology/physiopathology
KW - Weight Gain/physiology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Questionnaires
KW - Young Adult
KW - Case-Control Studies
KW - Risk
KW - Saliva/chemistry
KW - Anxiety/blood/epidemiology/physiopathology
KW - Feeding Behavior/physiology/psychology
KW - Hydrocortisone/blood/physiology
KW - Leptin/blood/physiology
KW - Smoking/blood/epidemiology/psychology
KW - Smoking Cessation/psychology/statistics & numerical data
KW - Stress, Psychological/epidemiology/physiopathology
KW - Weight Gain/physiology
M3 - SCORING: Journal article
VL - 60
SP - 58
EP - 64
JO - HORM BEHAV
JF - HORM BEHAV
SN - 0018-506X
IS - 1
M1 - 1
ER -
