PSA-Anstieg nach definitiver Therapie
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PSA-Anstieg nach definitiver Therapie. / Maurer, T; Hadaschik, B; Budäus, L; Steuber, T; Salomon, G; Horn, T; Herrmann, K; Weber, M; Giesel, F L; Berliner, C; Eiber, M.
In: UROLOGE, Vol. 58, No. 5, 05.2019, p. 569-582.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - PSA-Anstieg nach definitiver Therapie
AU - Maurer, T
AU - Hadaschik, B
AU - Budäus, L
AU - Steuber, T
AU - Salomon, G
AU - Horn, T
AU - Herrmann, K
AU - Weber, M
AU - Giesel, F L
AU - Berliner, C
AU - Eiber, M
PY - 2019/5
Y1 - 2019/5
N2 - Following definitive treatment with curative intent a subset of patients with prostate cancer experience biochemical recurrence. In these patients clinical parameters are mostly used to decide if a local or systemic disease recurrence is present. While salvage radiation treatment is advocated for local recurrence after radical prostatectomy, no standard recommendations exist in cases of local recurrence after primary radiation therapy although salvage prostatectomy may be considered. Imaging procedures have traditionally not routinely been recommended for the onset of prostate-specific antigen (PSA) relapse; however, prostate-specific membrane antigen (PSMA) positron emission tomography (PET) computed tomography (CT) exhibits high detection rates even at low PSA values. Thus, the current German guidelines state that PSMA PET/CT can be considered if this could result in a decisive change in further treatment management. Currently, a positive influence on oncological long-term outcome, however, has not yet been proven.
AB - Following definitive treatment with curative intent a subset of patients with prostate cancer experience biochemical recurrence. In these patients clinical parameters are mostly used to decide if a local or systemic disease recurrence is present. While salvage radiation treatment is advocated for local recurrence after radical prostatectomy, no standard recommendations exist in cases of local recurrence after primary radiation therapy although salvage prostatectomy may be considered. Imaging procedures have traditionally not routinely been recommended for the onset of prostate-specific antigen (PSA) relapse; however, prostate-specific membrane antigen (PSMA) positron emission tomography (PET) computed tomography (CT) exhibits high detection rates even at low PSA values. Thus, the current German guidelines state that PSMA PET/CT can be considered if this could result in a decisive change in further treatment management. Currently, a positive influence on oncological long-term outcome, however, has not yet been proven.
KW - English Abstract
KW - Journal Article
U2 - 10.1007/s00120-019-0931-4
DO - 10.1007/s00120-019-0931-4
M3 - SCORING: Zeitschriftenaufsatz
C2 - 31049635
VL - 58
SP - 569
EP - 582
JO - UROLOGE
JF - UROLOGE
SN - 0340-2592
IS - 5
ER -