Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications

Maria Andres-Alonso; Katarzyna M Grochowska; Eckart D Gundelfinger; Anna Karpova; Michael R Kreutz

doi:10.1016/j.mcn.2023.103854

Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications

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Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications. / Andres-Alonso, Maria; Grochowska, Katarzyna M; Gundelfinger, Eckart D; Karpova, Anna; Kreutz, Michael R.

In: MOL CELL NEUROSCI, Vol. 125, 103854, 06.2023.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Andres-Alonso, M, Grochowska, KM, Gundelfinger, ED, Karpova, A & Kreutz, MR 2023, 'Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications', MOL CELL NEUROSCI, vol. 125, 103854. https://doi.org/10.1016/j.mcn.2023.103854

APA

Andres-Alonso, M., Grochowska, K. M., Gundelfinger, E. D., Karpova, A., & Kreutz, M. R. (2023). Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications. MOL CELL NEUROSCI, 125, [103854]. https://doi.org/10.1016/j.mcn.2023.103854

Vancouver

Andres-Alonso M, Grochowska KM, Gundelfinger ED, Karpova A, Kreutz MR. Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications. MOL CELL NEUROSCI. 2023 Jun;125. 103854. https://doi.org/10.1016/j.mcn.2023.103854

Bibtex

@article{4c17ef1ed7f2408a84dadcbd9dbec875,

title = "Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications",

abstract = "The extreme length of neuronal processes poses a challenge for synapse-to-nucleus communication. In response to this challenge several different mechanisms have evolved in neurons to couple synaptic activity to the regulation of gene expression. One of these mechanisms concerns the long-distance transport of proteins from pre- and postsynaptic sites to the nucleus. In this review we summarize current evidence on mechanisms of transport and consequences of nuclear import of these proteins for gene transcription. In addition, we discuss how information from pre- and postsynaptic sites might be relayed to the nucleus by this type of long-distance signaling. When applicable, we highlight how long-distance protein transport from synapse-to-nucleus can provide insight into the pathophysiology of disease or reveal new opportunities for therapeutic intervention.",

keywords = "Protein Transport/physiology, Cell Nucleus/metabolism, Synapses/metabolism, Active Transport, Cell Nucleus/physiology, Neurons/physiology",

author = "Maria Andres-Alonso and Grochowska, {Katarzyna M} and Gundelfinger, {Eckart D} and Anna Karpova and Kreutz, {Michael R}",

year = "2023",

month = jun,

doi = "10.1016/j.mcn.2023.103854",

language = "English",

volume = "125",

journal = "MOL CELL NEUROSCI",

issn = "1044-7431",

publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications

AU - Andres-Alonso, Maria

AU - Grochowska, Katarzyna M

AU - Gundelfinger, Eckart D

AU - Karpova, Anna

AU - Kreutz, Michael R

PY - 2023/6

Y1 - 2023/6

N2 - The extreme length of neuronal processes poses a challenge for synapse-to-nucleus communication. In response to this challenge several different mechanisms have evolved in neurons to couple synaptic activity to the regulation of gene expression. One of these mechanisms concerns the long-distance transport of proteins from pre- and postsynaptic sites to the nucleus. In this review we summarize current evidence on mechanisms of transport and consequences of nuclear import of these proteins for gene transcription. In addition, we discuss how information from pre- and postsynaptic sites might be relayed to the nucleus by this type of long-distance signaling. When applicable, we highlight how long-distance protein transport from synapse-to-nucleus can provide insight into the pathophysiology of disease or reveal new opportunities for therapeutic intervention.

AB - The extreme length of neuronal processes poses a challenge for synapse-to-nucleus communication. In response to this challenge several different mechanisms have evolved in neurons to couple synaptic activity to the regulation of gene expression. One of these mechanisms concerns the long-distance transport of proteins from pre- and postsynaptic sites to the nucleus. In this review we summarize current evidence on mechanisms of transport and consequences of nuclear import of these proteins for gene transcription. In addition, we discuss how information from pre- and postsynaptic sites might be relayed to the nucleus by this type of long-distance signaling. When applicable, we highlight how long-distance protein transport from synapse-to-nucleus can provide insight into the pathophysiology of disease or reveal new opportunities for therapeutic intervention.

KW - Protein Transport/physiology

KW - Cell Nucleus/metabolism

KW - Synapses/metabolism

KW - Active Transport, Cell Nucleus/physiology

KW - Neurons/physiology

U2 - 10.1016/j.mcn.2023.103854

DO - 10.1016/j.mcn.2023.103854

M3 - SCORING: Review article

C2 - 37084990

VL - 125

JO - MOL CELL NEUROSCI

JF - MOL CELL NEUROSCI

SN - 1044-7431

M1 - 103854

ER -