Protein phosphatases and their potential implications in neuroprotective processes

C E Gee; I M Mansuy

doi:10.1007/s00018-005-5008-4

Protein phosphatases and their potential implications in neuroprotective processes

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Protein phosphatases and their potential implications in neuroprotective processes. / Gee, C E; Mansuy, I M.

In: CELL MOL LIFE SCI, Vol. 62, No. 10, 01.05.2005, p. 1120-30.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gee, CE & Mansuy, IM 2005, 'Protein phosphatases and their potential implications in neuroprotective processes', CELL MOL LIFE SCI, vol. 62, no. 10, pp. 1120-30. https://doi.org/10.1007/s00018-005-5008-4

APA

Gee, C. E., & Mansuy, I. M. (2005). Protein phosphatases and their potential implications in neuroprotective processes. CELL MOL LIFE SCI, 62(10), 1120-30. https://doi.org/10.1007/s00018-005-5008-4

Vancouver

Gee CE, Mansuy IM. Protein phosphatases and their potential implications in neuroprotective processes. CELL MOL LIFE SCI. 2005 May 1;62(10):1120-30. https://doi.org/10.1007/s00018-005-5008-4

Bibtex

@article{4a9df0fa81a541ec96ac7fbba494df0c,

title = "Protein phosphatases and their potential implications in neuroprotective processes",

abstract = "Several neurological disorders such as stroke, amyotrophic lateral sclerosis and epilepsy result from excitotoxic events and are accompanied by neuronal cell death. These processes engage multiple signalling pathways and recruit numerous molecular components, in particular several families of protein kinases and protein phosphatases. While many investigations have examined the importance of protein kinases in excitotoxicity, protein phosphatases have not been well studied in this context. However, recent advances in understanding the functions of protein phosphatases have suggested that they may play a neuroprotective role. In this review, we summarize some of the recent findings that illustrate the pleiotropic and complex functions of tyrosine and serine/threonine protein phosphatases in the cascade of events leading to neuronal cell death, and highlight their potential intervention in limiting the extent of neuronal death.",

keywords = "Animals, Cell Death, Cell Survival, Humans, Models, Biological, Nervous System, Phosphoprotein Phosphatases, Protein Tyrosine Phosphatases, Signal Transduction",

author = "Gee, {C E} and Mansuy, {I M}",

year = "2005",

month = may,

day = "1",

doi = "10.1007/s00018-005-5008-4",

language = "English",

volume = "62",

pages = "1120--30",

journal = "CELL MOL LIFE SCI",

issn = "1420-682X",

publisher = "Birkhauser Verlag Basel",

number = "10",

}

RIS

TY - JOUR

T1 - Protein phosphatases and their potential implications in neuroprotective processes

AU - Gee, C E

AU - Mansuy, I M

PY - 2005/5/1

Y1 - 2005/5/1

N2 - Several neurological disorders such as stroke, amyotrophic lateral sclerosis and epilepsy result from excitotoxic events and are accompanied by neuronal cell death. These processes engage multiple signalling pathways and recruit numerous molecular components, in particular several families of protein kinases and protein phosphatases. While many investigations have examined the importance of protein kinases in excitotoxicity, protein phosphatases have not been well studied in this context. However, recent advances in understanding the functions of protein phosphatases have suggested that they may play a neuroprotective role. In this review, we summarize some of the recent findings that illustrate the pleiotropic and complex functions of tyrosine and serine/threonine protein phosphatases in the cascade of events leading to neuronal cell death, and highlight their potential intervention in limiting the extent of neuronal death.

AB - Several neurological disorders such as stroke, amyotrophic lateral sclerosis and epilepsy result from excitotoxic events and are accompanied by neuronal cell death. These processes engage multiple signalling pathways and recruit numerous molecular components, in particular several families of protein kinases and protein phosphatases. While many investigations have examined the importance of protein kinases in excitotoxicity, protein phosphatases have not been well studied in this context. However, recent advances in understanding the functions of protein phosphatases have suggested that they may play a neuroprotective role. In this review, we summarize some of the recent findings that illustrate the pleiotropic and complex functions of tyrosine and serine/threonine protein phosphatases in the cascade of events leading to neuronal cell death, and highlight their potential intervention in limiting the extent of neuronal death.

KW - Animals

KW - Cell Death

KW - Cell Survival

KW - Humans

KW - Models, Biological

KW - Nervous System

KW - Phosphoprotein Phosphatases

KW - Protein Tyrosine Phosphatases

KW - Signal Transduction

U2 - 10.1007/s00018-005-5008-4

DO - 10.1007/s00018-005-5008-4

M3 - SCORING: Journal article

C2 - 15928806

VL - 62

SP - 1120

EP - 1130

JO - CELL MOL LIFE SCI

JF - CELL MOL LIFE SCI

SN - 1420-682X

IS - 10

ER -