Prostate-specific antigen improves the ability of clinical stage and biopsy Gleason sum to predict the pathologic stage at radical prostatectomy in the new millennium.
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Prostate-specific antigen improves the ability of clinical stage and biopsy Gleason sum to predict the pathologic stage at radical prostatectomy in the new millennium. / Chun, Felix; Briganti, Alberto; Gallina, Andrea; Hutterer, Georg C; Shariat, Shahrokh F; Antebie, Elie; Walz, Jochen; Roehrborn, Claus G; Salonia, Andrea; Rigatti, Patrizio; Saad, Fred; Huland, Hartwig; Montorsi, Francesco; Graefen, Markus; Karakiewicz, Pierre I.
In: EUR UROL, Vol. 52, No. 4, 4, 2007, p. 1067-1074.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Prostate-specific antigen improves the ability of clinical stage and biopsy Gleason sum to predict the pathologic stage at radical prostatectomy in the new millennium.
AU - Chun, Felix
AU - Briganti, Alberto
AU - Gallina, Andrea
AU - Hutterer, Georg C
AU - Shariat, Shahrokh F
AU - Antebie, Elie
AU - Walz, Jochen
AU - Roehrborn, Claus G
AU - Salonia, Andrea
AU - Rigatti, Patrizio
AU - Saad, Fred
AU - Huland, Hartwig
AU - Montorsi, Francesco
AU - Graefen, Markus
AU - Karakiewicz, Pierre I
PY - 2007
Y1 - 2007
N2 - OBJECTIVES: The contemporary ability of prostate-specific antigen (PSA) to predict pathologic stage in men with localized prostate cancer was recently questioned. METHODS: We quantified the added value related to the addition of pretreatment PSA to established pathologic stage predictors (namely clinical stage and biopsy Gleason sum) in 5921 consecutive radical prostatectomy (RP) patients. Univariable and multivariable logistic regression analyses predicting pathologic stage (extracapsular extension [ECE], seminal vesicle invasion [SVI], lymph node invasion [LNI], and organ-confined disease [OC]) were stratified according to four time quartiles. The gain in predictive accuracy (PA) related to the inclusion of PSA to multivariable models was quantified by using the area under the curve method. RESULTS: Temporal analyses showed a decrease in PSA levels over the study years (p
AB - OBJECTIVES: The contemporary ability of prostate-specific antigen (PSA) to predict pathologic stage in men with localized prostate cancer was recently questioned. METHODS: We quantified the added value related to the addition of pretreatment PSA to established pathologic stage predictors (namely clinical stage and biopsy Gleason sum) in 5921 consecutive radical prostatectomy (RP) patients. Univariable and multivariable logistic regression analyses predicting pathologic stage (extracapsular extension [ECE], seminal vesicle invasion [SVI], lymph node invasion [LNI], and organ-confined disease [OC]) were stratified according to four time quartiles. The gain in predictive accuracy (PA) related to the inclusion of PSA to multivariable models was quantified by using the area under the curve method. RESULTS: Temporal analyses showed a decrease in PSA levels over the study years (p
M3 - SCORING: Zeitschriftenaufsatz
VL - 52
SP - 1067
EP - 1074
JO - EUR UROL
JF - EUR UROL
SN - 0302-2838
IS - 4
M1 - 4
ER -