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Prospective Sero-epidemiological Evaluation of SARS-CoV-2 among Health Care Workers in a German Secondary Care Hospital

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Prospective Sero-epidemiological Evaluation of SARS-CoV-2 among Health Care Workers in a German Secondary Care Hospital. / Herzberg, Jonas; Vollmer, Tanja; Fischer, Bastian; Becher, Heiko; Becker, Ann-Kristin; Sahly, Hany; Honarpisheh, Human; Guraya, Salman Yousuf; Strate, Tim; Knabbe, Cornelius.

In: INT J INFECT DIS, Vol. 102, 01.2021, p. 136-143.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Herzberg, J, Vollmer, T, Fischer, B, Becher, H, Becker, A-K, Sahly, H, Honarpisheh, H, Guraya, SY, Strate, T & Knabbe, C 2021, 'Prospective Sero-epidemiological Evaluation of SARS-CoV-2 among Health Care Workers in a German Secondary Care Hospital', INT J INFECT DIS, vol. 102, pp. 136-143. https://doi.org/10.1016/j.ijid.2020.10.026

APA

Herzberg, J., Vollmer, T., Fischer, B., Becher, H., Becker, A-K., Sahly, H., Honarpisheh, H., Guraya, S. Y., Strate, T., & Knabbe, C. (2021). Prospective Sero-epidemiological Evaluation of SARS-CoV-2 among Health Care Workers in a German Secondary Care Hospital. INT J INFECT DIS, 102, 136-143. https://doi.org/10.1016/j.ijid.2020.10.026

Vancouver

Herzberg J, Vollmer T, Fischer B, Becher H, Becker A-K, Sahly H et al. Prospective Sero-epidemiological Evaluation of SARS-CoV-2 among Health Care Workers in a German Secondary Care Hospital. INT J INFECT DIS. 2021 Jan;102:136-143. https://doi.org/10.1016/j.ijid.2020.10.026

Bibtex

@article{37b9699a35e44021a2701f8724373ba2,
title = "Prospective Sero-epidemiological Evaluation of SARS-CoV-2 among Health Care Workers in a German Secondary Care Hospital",
abstract = "OBJECTIVES: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the pulmonary disease coronavirus disease 2019 (COVID-19, which has challenged health care facilities worldwide. The sustainability of health care systems is largely reliant on the health status of their health care workers (HCW). This study aimed to detect the SARS-CoV-2 virus and specific antibodies among HCWs in a German hospital as a model system for the potential spread of the pandemic.METHODS: Between March and June 2020, we used a combination of RT-PCR testing to detect SARS-CoV-2 RNA and an enzyme-linked immunosorbent assay to detect the presence of anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies among HCWs in a German hospital based on repetitive oropharyngeal swabs (OPSs) and blood samples.RESULTS: In total, 871/1081 employees participated in this prospective longitudinal study. During the study period of 9 weeks, 5329 OPSs and 2136 blood samples were analyzed. SARS-CoV-2 RNA was detected in three participants (0.34%). Anti-SARS-CoV-2 IgG antibodies were detected in 38 (4.36%) participants.CONCLUSION: Our study determined a low prevalence of COVID-19 in HCW, which may reflect the effectiveness of hygiene protocols. However, it could also indicate a low prevalence of SARS CoV-2 in hospital employees. Our study protocol may serve as an instructive example for future pandemic containment protocols in hospitals.",
author = "Jonas Herzberg and Tanja Vollmer and Bastian Fischer and Heiko Becher and Ann-Kristin Becker and Hany Sahly and Human Honarpisheh and Guraya, {Salman Yousuf} and Tim Strate and Cornelius Knabbe",
note = "Copyright {\textcopyright} 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.",
year = "2021",
month = jan,
doi = "10.1016/j.ijid.2020.10.026",
language = "English",
volume = "102",
pages = "136--143",
journal = "INT J INFECT DIS",
issn = "1201-9712",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Prospective Sero-epidemiological Evaluation of SARS-CoV-2 among Health Care Workers in a German Secondary Care Hospital

AU - Herzberg, Jonas

AU - Vollmer, Tanja

AU - Fischer, Bastian

AU - Becher, Heiko

AU - Becker, Ann-Kristin

AU - Sahly, Hany

AU - Honarpisheh, Human

AU - Guraya, Salman Yousuf

AU - Strate, Tim

AU - Knabbe, Cornelius

N1 - Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

PY - 2021/1

Y1 - 2021/1

N2 - OBJECTIVES: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the pulmonary disease coronavirus disease 2019 (COVID-19, which has challenged health care facilities worldwide. The sustainability of health care systems is largely reliant on the health status of their health care workers (HCW). This study aimed to detect the SARS-CoV-2 virus and specific antibodies among HCWs in a German hospital as a model system for the potential spread of the pandemic.METHODS: Between March and June 2020, we used a combination of RT-PCR testing to detect SARS-CoV-2 RNA and an enzyme-linked immunosorbent assay to detect the presence of anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies among HCWs in a German hospital based on repetitive oropharyngeal swabs (OPSs) and blood samples.RESULTS: In total, 871/1081 employees participated in this prospective longitudinal study. During the study period of 9 weeks, 5329 OPSs and 2136 blood samples were analyzed. SARS-CoV-2 RNA was detected in three participants (0.34%). Anti-SARS-CoV-2 IgG antibodies were detected in 38 (4.36%) participants.CONCLUSION: Our study determined a low prevalence of COVID-19 in HCW, which may reflect the effectiveness of hygiene protocols. However, it could also indicate a low prevalence of SARS CoV-2 in hospital employees. Our study protocol may serve as an instructive example for future pandemic containment protocols in hospitals.

AB - OBJECTIVES: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the pulmonary disease coronavirus disease 2019 (COVID-19, which has challenged health care facilities worldwide. The sustainability of health care systems is largely reliant on the health status of their health care workers (HCW). This study aimed to detect the SARS-CoV-2 virus and specific antibodies among HCWs in a German hospital as a model system for the potential spread of the pandemic.METHODS: Between March and June 2020, we used a combination of RT-PCR testing to detect SARS-CoV-2 RNA and an enzyme-linked immunosorbent assay to detect the presence of anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies among HCWs in a German hospital based on repetitive oropharyngeal swabs (OPSs) and blood samples.RESULTS: In total, 871/1081 employees participated in this prospective longitudinal study. During the study period of 9 weeks, 5329 OPSs and 2136 blood samples were analyzed. SARS-CoV-2 RNA was detected in three participants (0.34%). Anti-SARS-CoV-2 IgG antibodies were detected in 38 (4.36%) participants.CONCLUSION: Our study determined a low prevalence of COVID-19 in HCW, which may reflect the effectiveness of hygiene protocols. However, it could also indicate a low prevalence of SARS CoV-2 in hospital employees. Our study protocol may serve as an instructive example for future pandemic containment protocols in hospitals.

U2 - 10.1016/j.ijid.2020.10.026

DO - 10.1016/j.ijid.2020.10.026

M3 - SCORING: Journal article

C2 - 33075538

VL - 102

SP - 136

EP - 143

JO - INT J INFECT DIS

JF - INT J INFECT DIS

SN - 1201-9712

ER -