Prospective respiratory-triggered 64-slice CT pulmonary angiography for detection of pulmonary embolism--a feasibility study in a porcine model.
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Prospective respiratory-triggered 64-slice CT pulmonary angiography for detection of pulmonary embolism--a feasibility study in a porcine model. / Henes, Frank Oliver; Groth, Michael; Regier, Marc; Bley, Thorsten; Nagel, Hans-Dieter; Adam, Gerhard; Begemann, Philipp.
In: EMERG RADIOL, Vol. 17, No. 6, 6, 2010, p. 465-471.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Prospective respiratory-triggered 64-slice CT pulmonary angiography for detection of pulmonary embolism--a feasibility study in a porcine model.
AU - Henes, Frank Oliver
AU - Groth, Michael
AU - Regier, Marc
AU - Bley, Thorsten
AU - Nagel, Hans-Dieter
AU - Adam, Gerhard
AU - Begemann, Philipp
PY - 2010
Y1 - 2010
N2 - The objective of this study is to investigate the feasibility of prospectively respiratory-triggered CT pulmonary angiography (CTPA) for detection of pulmonary embolism (PE) in a porcine model. A free-breathing respiratory-triggered multislice CTPA (120 kV, 140 mAs(eff), 2.5-mm slice thickness) and two CTPA in breath-hold technique (120 kV, 140 mAs(eff.) and 250mAs(eff), 1-mm and 3-mm image reconstruction) were performed in six pigs with pulmonary embolism. Diagnostic accuracy was computed, and differences in detection rates between both techniques were assessed on a per-embolus basis with the Wilcoxon test. Thin-sliced 1-mm images, acquired with 250mAs(eff), served as the standard of reference. Respiratory-triggered CTPA reached high diagnostic accuracy in detection of lobar and segmental PE equal to the results with the breath-hold technique (p > 0.05). For detection of subsegmental emboli, standard breath-hold techniques performed significantly better than respiratory-gated CTPA (sensitivity, 68.3% versus 24.4%; p <0.05). Free-breathing respiratory-triggered CTPA is feasible for detection of lobar and segmental PE, with diagnostic accuracy equivalent to that of a standard CTPA in breath-hold. Although this technique is not recommended for assessment of emboli in the subsegmental vasculature, prospective respiratory-triggered CTPA may be of added value in patients who cannot hold their breath appropriately for CTPA scanning.
AB - The objective of this study is to investigate the feasibility of prospectively respiratory-triggered CT pulmonary angiography (CTPA) for detection of pulmonary embolism (PE) in a porcine model. A free-breathing respiratory-triggered multislice CTPA (120 kV, 140 mAs(eff), 2.5-mm slice thickness) and two CTPA in breath-hold technique (120 kV, 140 mAs(eff.) and 250mAs(eff), 1-mm and 3-mm image reconstruction) were performed in six pigs with pulmonary embolism. Diagnostic accuracy was computed, and differences in detection rates between both techniques were assessed on a per-embolus basis with the Wilcoxon test. Thin-sliced 1-mm images, acquired with 250mAs(eff), served as the standard of reference. Respiratory-triggered CTPA reached high diagnostic accuracy in detection of lobar and segmental PE equal to the results with the breath-hold technique (p > 0.05). For detection of subsegmental emboli, standard breath-hold techniques performed significantly better than respiratory-gated CTPA (sensitivity, 68.3% versus 24.4%; p <0.05). Free-breathing respiratory-triggered CTPA is feasible for detection of lobar and segmental PE, with diagnostic accuracy equivalent to that of a standard CTPA in breath-hold. Although this technique is not recommended for assessment of emboli in the subsegmental vasculature, prospective respiratory-triggered CTPA may be of added value in patients who cannot hold their breath appropriately for CTPA scanning.
M3 - SCORING: Zeitschriftenaufsatz
VL - 17
SP - 465
EP - 471
JO - EMERG RADIOL
JF - EMERG RADIOL
SN - 1070-3004
IS - 6
M1 - 6
ER -
