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Prospective evaluation of the short access cholangioscopy for stone clearance and evaluation of indeterminate strictures

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Prospective evaluation of the short access cholangioscopy for stone clearance and evaluation of indeterminate strictures. / Sioulas, Athanasios D; El-Masry, Muhammad A; Groth, Stefan; Schachschal, Guido; Anders, Mario; Rosch, Thomas; Denzer, Ulrike.

In: HEPATOB PANCREAT DIS, Vol. 16, No. 1, 02.2017, p. 96-103.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sioulas, AD, El-Masry, MA, Groth, S, Schachschal, G, Anders, M, Rosch, T & Denzer, U 2017, 'Prospective evaluation of the short access cholangioscopy for stone clearance and evaluation of indeterminate strictures', HEPATOB PANCREAT DIS, vol. 16, no. 1, pp. 96-103.

APA

Sioulas, A. D., El-Masry, M. A., Groth, S., Schachschal, G., Anders, M., Rosch, T., & Denzer, U. (2017). Prospective evaluation of the short access cholangioscopy for stone clearance and evaluation of indeterminate strictures. HEPATOB PANCREAT DIS, 16(1), 96-103.

Vancouver

Sioulas AD, El-Masry MA, Groth S, Schachschal G, Anders M, Rosch T et al. Prospective evaluation of the short access cholangioscopy for stone clearance and evaluation of indeterminate strictures. HEPATOB PANCREAT DIS. 2017 Feb;16(1):96-103.

Bibtex

@article{948af51a3f7d47ffbe8ac2322614133e,
title = "Prospective evaluation of the short access cholangioscopy for stone clearance and evaluation of indeterminate strictures",
abstract = "BACKGROUND: Peroral cholangioscopy facilitates diagnosis and therapy of biliary disorders. This study prospectively evaluated a new short access cholangioscopy.METHODS: Consecutive patients were included as follows: difficult stones (group 1) underwent cholangioscopy with electrohydraulic lithotripsy and indeterminate biliary strictures (group 2) were evaluated with macroscopic assessment and cholangioscopy guided biopsy sampling. We evaluated the complete stone clearance rate (group 1) and diagnostic accuracy (group 2). Follow-up was performed over a median of 13 and 16 months, respectively.RESULTS: Group 1 (n=21): complete stone clearance defined as lack of stones in cholangiography and stone removal during cholangioscopy was achieved in 15 (71.4%) patients. Clinical stone clearance defined as lack of symptoms, laboratory abnormalities and hospital visits during follow-up, irrespective of stone clearance was evident in 17 (81.0%) patients. One serious adverse event occurred (bile duct perforation). Group 2 (n=28): malignancy was confirmed in 15 patients. Sensitivity, specificity and diagnostic accuracy of cholangioscopy were 85.7%, 75.0% and 80.7%, respectively. Sensitivity, specificity and diagnostic accuracy of biopsies were 54.5%, 100.0% and 72.2%, respectively. No serious adverse events occurred, and one patient was lost to follow-up.CONCLUSIONS: The novel system enabled complex stone treatment and biliary stricture diagnosis. Cholangioscopy outperformed direct biopsy regarding characterization of indeterminate strictures.",
keywords = "Adult, Aged, Aged, 80 and over, Bile Ducts, Biopsy, Cholestasis, Constriction, Pathologic, Endoscopes, Endoscopy, Digestive System, Equipment Design, Feasibility Studies, Female, Gallstones, Germany, Humans, Lithotripsy, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Reproducibility of Results, Time Factors, Treatment Outcome, Comparative Study, Journal Article",
author = "Sioulas, {Athanasios D} and El-Masry, {Muhammad A} and Stefan Groth and Guido Schachschal and Mario Anders and Thomas Rosch and Ulrike Denzer",
year = "2017",
month = feb,
language = "English",
volume = "16",
pages = "96--103",
journal = "HEPATOB PANCREAT DIS",
issn = "1499-3872",
publisher = "HBPD INT Press",
number = "1",

}

RIS

TY - JOUR

T1 - Prospective evaluation of the short access cholangioscopy for stone clearance and evaluation of indeterminate strictures

AU - Sioulas, Athanasios D

AU - El-Masry, Muhammad A

AU - Groth, Stefan

AU - Schachschal, Guido

AU - Anders, Mario

AU - Rosch, Thomas

AU - Denzer, Ulrike

PY - 2017/2

Y1 - 2017/2

N2 - BACKGROUND: Peroral cholangioscopy facilitates diagnosis and therapy of biliary disorders. This study prospectively evaluated a new short access cholangioscopy.METHODS: Consecutive patients were included as follows: difficult stones (group 1) underwent cholangioscopy with electrohydraulic lithotripsy and indeterminate biliary strictures (group 2) were evaluated with macroscopic assessment and cholangioscopy guided biopsy sampling. We evaluated the complete stone clearance rate (group 1) and diagnostic accuracy (group 2). Follow-up was performed over a median of 13 and 16 months, respectively.RESULTS: Group 1 (n=21): complete stone clearance defined as lack of stones in cholangiography and stone removal during cholangioscopy was achieved in 15 (71.4%) patients. Clinical stone clearance defined as lack of symptoms, laboratory abnormalities and hospital visits during follow-up, irrespective of stone clearance was evident in 17 (81.0%) patients. One serious adverse event occurred (bile duct perforation). Group 2 (n=28): malignancy was confirmed in 15 patients. Sensitivity, specificity and diagnostic accuracy of cholangioscopy were 85.7%, 75.0% and 80.7%, respectively. Sensitivity, specificity and diagnostic accuracy of biopsies were 54.5%, 100.0% and 72.2%, respectively. No serious adverse events occurred, and one patient was lost to follow-up.CONCLUSIONS: The novel system enabled complex stone treatment and biliary stricture diagnosis. Cholangioscopy outperformed direct biopsy regarding characterization of indeterminate strictures.

AB - BACKGROUND: Peroral cholangioscopy facilitates diagnosis and therapy of biliary disorders. This study prospectively evaluated a new short access cholangioscopy.METHODS: Consecutive patients were included as follows: difficult stones (group 1) underwent cholangioscopy with electrohydraulic lithotripsy and indeterminate biliary strictures (group 2) were evaluated with macroscopic assessment and cholangioscopy guided biopsy sampling. We evaluated the complete stone clearance rate (group 1) and diagnostic accuracy (group 2). Follow-up was performed over a median of 13 and 16 months, respectively.RESULTS: Group 1 (n=21): complete stone clearance defined as lack of stones in cholangiography and stone removal during cholangioscopy was achieved in 15 (71.4%) patients. Clinical stone clearance defined as lack of symptoms, laboratory abnormalities and hospital visits during follow-up, irrespective of stone clearance was evident in 17 (81.0%) patients. One serious adverse event occurred (bile duct perforation). Group 2 (n=28): malignancy was confirmed in 15 patients. Sensitivity, specificity and diagnostic accuracy of cholangioscopy were 85.7%, 75.0% and 80.7%, respectively. Sensitivity, specificity and diagnostic accuracy of biopsies were 54.5%, 100.0% and 72.2%, respectively. No serious adverse events occurred, and one patient was lost to follow-up.CONCLUSIONS: The novel system enabled complex stone treatment and biliary stricture diagnosis. Cholangioscopy outperformed direct biopsy regarding characterization of indeterminate strictures.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Bile Ducts

KW - Biopsy

KW - Cholestasis

KW - Constriction, Pathologic

KW - Endoscopes

KW - Endoscopy, Digestive System

KW - Equipment Design

KW - Feasibility Studies

KW - Female

KW - Gallstones

KW - Germany

KW - Humans

KW - Lithotripsy

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Reproducibility of Results

KW - Time Factors

KW - Treatment Outcome

KW - Comparative Study

KW - Journal Article

M3 - SCORING: Journal article

C2 - 28119264

VL - 16

SP - 96

EP - 103

JO - HEPATOB PANCREAT DIS

JF - HEPATOB PANCREAT DIS

SN - 1499-3872

IS - 1

ER -