Prospective Clinical and Molecular Evaluation of Potential Plasmodium ovale curtisi and wallikeri Relapses in a High-transmission Setting
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Prospective Clinical and Molecular Evaluation of Potential Plasmodium ovale curtisi and wallikeri Relapses in a High-transmission Setting. / Groger, Mirjam; Veletzky, Luzia; Lalremruata, Albert; Cattaneo, Chiara; Mischlinger, Johannes; Manego Zoleko, Rella; Kim, Johanna; Klicpera, Anna; Meyer, Elias L; Blessborn, Daniel; Winterberg, Markus; Adegnika, Ayola A; Agnandji, Selidji T; Kremsner, Peter G; Mordmüller, Benjamin; Mombo-Ngoma, Ghyslain; Fuehrer, Hans-Peter; Ramharter, Michael.
In: CLIN INFECT DIS, Vol. 69, No. 12, 27.11.2019, p. 2119-2126.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Prospective Clinical and Molecular Evaluation of Potential Plasmodium ovale curtisi and wallikeri Relapses in a High-transmission Setting
AU - Groger, Mirjam
AU - Veletzky, Luzia
AU - Lalremruata, Albert
AU - Cattaneo, Chiara
AU - Mischlinger, Johannes
AU - Manego Zoleko, Rella
AU - Kim, Johanna
AU - Klicpera, Anna
AU - Meyer, Elias L
AU - Blessborn, Daniel
AU - Winterberg, Markus
AU - Adegnika, Ayola A
AU - Agnandji, Selidji T
AU - Kremsner, Peter G
AU - Mordmüller, Benjamin
AU - Mombo-Ngoma, Ghyslain
AU - Fuehrer, Hans-Peter
AU - Ramharter, Michael
N1 - © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
PY - 2019/11/27
Y1 - 2019/11/27
N2 - BACKGROUND: Plasmodium ovale curtisi and wallikeri are perceived as relapsing malarial parasites. Contrary to Plasmodium vivax, direct evidence for this hypothesis is scarce. The aim of this prospective study was to characterize the reappearance patterns of ovale parasites.METHODS: P. ovale spp. infected patients were treated with artemether-lumefantrine and followed biweekly for up to 1 year for the detection of reappearing parasitemia. Molecular analysis of reappearing isolates was performed to identify homologous isolates by genotyping and to define cases of relapse following predefined criteria.RESULTS: At inclusion, 26 participants were positive for P. ovale curtisi and/or P. ovale wallikeri. The median duration of follow-up was 35 weeks. Reappearance of the same P. ovale species was observed in 46% of participants; 61% of P. ovale curtisi and 19% of P. ovale wallikeri infection-free intervals were estimated to end with reappearance by week 32. Based on the predefined criteria, 23% of participants were identified with 1 or 2 relapses, all induced by P. ovale curtisi.CONCLUSION: These findings are in line with the currently accepted relapse theory inasmuch as the reappearance of P. ovale curtisi strains following initial blood clearance was conclusively demonstrated. Interestingly, no relapse of P. ovale wallikeri was observed.
AB - BACKGROUND: Plasmodium ovale curtisi and wallikeri are perceived as relapsing malarial parasites. Contrary to Plasmodium vivax, direct evidence for this hypothesis is scarce. The aim of this prospective study was to characterize the reappearance patterns of ovale parasites.METHODS: P. ovale spp. infected patients were treated with artemether-lumefantrine and followed biweekly for up to 1 year for the detection of reappearing parasitemia. Molecular analysis of reappearing isolates was performed to identify homologous isolates by genotyping and to define cases of relapse following predefined criteria.RESULTS: At inclusion, 26 participants were positive for P. ovale curtisi and/or P. ovale wallikeri. The median duration of follow-up was 35 weeks. Reappearance of the same P. ovale species was observed in 46% of participants; 61% of P. ovale curtisi and 19% of P. ovale wallikeri infection-free intervals were estimated to end with reappearance by week 32. Based on the predefined criteria, 23% of participants were identified with 1 or 2 relapses, all induced by P. ovale curtisi.CONCLUSION: These findings are in line with the currently accepted relapse theory inasmuch as the reappearance of P. ovale curtisi strains following initial blood clearance was conclusively demonstrated. Interestingly, no relapse of P. ovale wallikeri was observed.
U2 - 10.1093/cid/ciz131
DO - 10.1093/cid/ciz131
M3 - SCORING: Journal article
C2 - 31066448
VL - 69
SP - 2119
EP - 2126
JO - CLIN INFECT DIS
JF - CLIN INFECT DIS
SN - 1058-4838
IS - 12
ER -