Progression of microstructural putamen alterations in a case of symptomatic recurrent seizures using diffusion tensor imaging
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Progression of microstructural putamen alterations in a case of symptomatic recurrent seizures using diffusion tensor imaging. / Gerdes, Jan S; Keller, Simon S; Schwindt, Wolfram; Evers, Stefan; Mohammadi, Siawoosh; Deppe, Michael.
In: SEIZURE-EUR J EPILEP, Vol. 21, No. 6, 01.07.2012, p. 478-81.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Progression of microstructural putamen alterations in a case of symptomatic recurrent seizures using diffusion tensor imaging
AU - Gerdes, Jan S
AU - Keller, Simon S
AU - Schwindt, Wolfram
AU - Evers, Stefan
AU - Mohammadi, Siawoosh
AU - Deppe, Michael
N1 - Copyright © 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Microstructural alterations of the putamen were recently reported in patients with partial and generalized epilepsy disorders. However, it is unknown whether these alterations pre-exist or are secondary to recurrent seizures. Here we investigated the progression of putamen fractional anisotropy (FA) alterations in a case of recurrent psychomotor seizures using longitudinal diffusion tensor imaging (DTI) shortly before (DTI-1) and after a psychomotor seizure (DTI-2). We obtained FA values of a hypothesis-guided putamen region-of-interest (ROI) and seven exploratory ROIs. FA values from both DTIs were compared with reference values from 19 controls. Relative to controls, the patient's putamen FA was increased at DTI-1 (13% left putamen, 7% right putamen), an effect that was exacerbated at DTI-2 (24% left putamen (p<0.05), 20% right putamen). In the exploratory ROIs we found FA reductions in the corticospinal tract, temporal lobe, and occipital lobe (p<0.05) relative to controls at DTI-1 and DTI-2. In contrast to the putamen, all exploratory ROIs showed no relevant FA change between DTI-1 and DTI-2. These results suggest that recurrent seizures may lead to progressive microstructural putamen alterations.
AB - Microstructural alterations of the putamen were recently reported in patients with partial and generalized epilepsy disorders. However, it is unknown whether these alterations pre-exist or are secondary to recurrent seizures. Here we investigated the progression of putamen fractional anisotropy (FA) alterations in a case of recurrent psychomotor seizures using longitudinal diffusion tensor imaging (DTI) shortly before (DTI-1) and after a psychomotor seizure (DTI-2). We obtained FA values of a hypothesis-guided putamen region-of-interest (ROI) and seven exploratory ROIs. FA values from both DTIs were compared with reference values from 19 controls. Relative to controls, the patient's putamen FA was increased at DTI-1 (13% left putamen, 7% right putamen), an effect that was exacerbated at DTI-2 (24% left putamen (p<0.05), 20% right putamen). In the exploratory ROIs we found FA reductions in the corticospinal tract, temporal lobe, and occipital lobe (p<0.05) relative to controls at DTI-1 and DTI-2. In contrast to the putamen, all exploratory ROIs showed no relevant FA change between DTI-1 and DTI-2. These results suggest that recurrent seizures may lead to progressive microstructural putamen alterations.
KW - Anisotropy
KW - Diffusion Tensor Imaging
KW - Disease Progression
KW - Epilepsies, Partial
KW - Female
KW - Humans
KW - Middle Aged
KW - Putamen
KW - Recurrence
KW - Seizures
U2 - 10.1016/j.seizure.2012.03.015
DO - 10.1016/j.seizure.2012.03.015
M3 - SCORING: Journal article
C2 - 22546528
VL - 21
SP - 478
EP - 481
JO - SEIZURE-EUR J EPILEP
JF - SEIZURE-EUR J EPILEP
SN - 1059-1311
IS - 6
ER -
