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Prognostic Value of Tricuspid Valve Gradient After Transcatheter Edge-to-Edge Repair: Insights From the TriValve Registry

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Prognostic Value of Tricuspid Valve Gradient After Transcatheter Edge-to-Edge Repair: Insights From the TriValve Registry. / Coisne, Augustin; Scotti, Andrea; Taramasso, Maurizio; Granada, Juan F; Ludwig, Sebastian; Rodés-Cabau, Josep; Lurz, Philipp; Hausleiter, Jörg; Fam, Neil; Kodali, Susheel K; Pozzoli, Alberto; Alessandrini, Hannes; Biasco, Luigi; Brochet, Eric; Denti, Paolo; Estevez-Loureiro, Rodrigo; Frerker, Christian; Ho, Edwin C; Monivas, Vanessa; Nickenig, Georg; Praz, Fabien; Puri, Rishi; Sievert, Horst; Tang, Gilbert H L; Andreas, Martin; Von Bardeleben, Ralph Stephan; Rommel, Karl-Philipp; Muntané-Carol, Guillem; Gavazzoni, Mara; Braun, Daniel; Lubos, Edith; Kalbacher, Daniel; Connelly, Kim A; Juliard, Jean-Michel; Harr, Claudia; Pedrazzini, Giovanni; Philippon, François; Schofer, Joachim; Thiele, Holger; Unterhuber, Matthias; Himbert, Dominique; Alcázar, Marina Ureña; Wild, Mirjam G; Jorde, Ulrich; Windecker, Stephan; Maisano, Francesco; Leon, Martin B; Hahn, Rebecca T; Latib, Azeem.

In: JACC-CARDIOVASC INTE, Vol. 16, No. 6, 27.03.2023, p. 706-717.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Coisne, A, Scotti, A, Taramasso, M, Granada, JF, Ludwig, S, Rodés-Cabau, J, Lurz, P, Hausleiter, J, Fam, N, Kodali, SK, Pozzoli, A, Alessandrini, H, Biasco, L, Brochet, E, Denti, P, Estevez-Loureiro, R, Frerker, C, Ho, EC, Monivas, V, Nickenig, G, Praz, F, Puri, R, Sievert, H, Tang, GHL, Andreas, M, Von Bardeleben, RS, Rommel, K-P, Muntané-Carol, G, Gavazzoni, M, Braun, D, Lubos, E, Kalbacher, D, Connelly, KA, Juliard, J-M, Harr, C, Pedrazzini, G, Philippon, F, Schofer, J, Thiele, H, Unterhuber, M, Himbert, D, Alcázar, MU, Wild, MG, Jorde, U, Windecker, S, Maisano, F, Leon, MB, Hahn, RT & Latib, A 2023, 'Prognostic Value of Tricuspid Valve Gradient After Transcatheter Edge-to-Edge Repair: Insights From the TriValve Registry', JACC-CARDIOVASC INTE, vol. 16, no. 6, pp. 706-717. https://doi.org/10.1016/j.jcin.2023.01.375

APA

Coisne, A., Scotti, A., Taramasso, M., Granada, J. F., Ludwig, S., Rodés-Cabau, J., Lurz, P., Hausleiter, J., Fam, N., Kodali, S. K., Pozzoli, A., Alessandrini, H., Biasco, L., Brochet, E., Denti, P., Estevez-Loureiro, R., Frerker, C., Ho, E. C., Monivas, V., ... Latib, A. (2023). Prognostic Value of Tricuspid Valve Gradient After Transcatheter Edge-to-Edge Repair: Insights From the TriValve Registry. JACC-CARDIOVASC INTE, 16(6), 706-717. https://doi.org/10.1016/j.jcin.2023.01.375

Vancouver

Coisne A, Scotti A, Taramasso M, Granada JF, Ludwig S, Rodés-Cabau J et al. Prognostic Value of Tricuspid Valve Gradient After Transcatheter Edge-to-Edge Repair: Insights From the TriValve Registry. JACC-CARDIOVASC INTE. 2023 Mar 27;16(6):706-717. https://doi.org/10.1016/j.jcin.2023.01.375

Bibtex

@article{06db5f91782847c4b30e1d23f84db1ee,
title = "Prognostic Value of Tricuspid Valve Gradient After Transcatheter Edge-to-Edge Repair: Insights From the TriValve Registry",
abstract = "BACKGROUND: Data regarding the impact of the tricuspid valve gradient (TVG) after tricuspid transcatheter edge-to-edge repair (TEER) are scarce.OBJECTIVES: This study sought to evaluate the association between the mean TVG and clinical outcomes among patients who underwent tricuspid TEER for significant tricuspid regurgitation.METHODS: Patients with significant tricuspid regurgitation who underwent tricuspid TEER within the TriValve (International Multisite Transcatheter Tricuspid Valve Therapies) registry were divided into quartiles based on the mean TVG at discharge. The primary endpoint was the composite of all-cause mortality and heart failure hospitalization. Outcomes were assessed up to the 1-year follow-up.RESULTS: A total of 308 patients were included from 24 centers. Patients were divided into quartiles of the mean TVG as follows: quartile 1 (n = 77), 0.9 ± 0.3 mm Hg; quartile 2 (n = 115), 1.8 ± 0.3 mm Hg; quartile 3 (n = 65), 2.8 ± 0.3 mm Hg; and quartile 4 (n = 51), 4.7 ± 2.0 mm Hg. The baseline TVG and the number of implanted clips were associated with a higher post-TEER TVG. There was no significant difference across TVG quartiles in the 1-year composite endpoint (quartiles 1-4: 35%, 30%, 40%, and 34%, respectively; P = 0.60) or the proportion of patients in New York Heart Association class III to IV at the last follow-up (P = 0.63). The results were similar after adjustment for clinical and echocardiographic characteristics (composite endpoint quartile 4 vs quartile 1-quartile 3 adjusted HR: 1.05; 95% CI: 0.52-2.12; P = 0.88) or exploring post-TEER TVG as a continuous variable.CONCLUSIONS: In this retrospective analysis of the TriValve registry, an increased discharge TVG was not significantly associated with adverse outcomes after tricuspid TEER. These findings apply for the explored TVG range and up to the 1-year follow-up. Further investigations on higher gradients and longer follow-up are needed to better guide the intraprocedural decision-making process.",
author = "Augustin Coisne and Andrea Scotti and Maurizio Taramasso and Granada, {Juan F} and Sebastian Ludwig and Josep Rod{\'e}s-Cabau and Philipp Lurz and J{\"o}rg Hausleiter and Neil Fam and Kodali, {Susheel K} and Alberto Pozzoli and Hannes Alessandrini and Luigi Biasco and Eric Brochet and Paolo Denti and Rodrigo Estevez-Loureiro and Christian Frerker and Ho, {Edwin C} and Vanessa Monivas and Georg Nickenig and Fabien Praz and Rishi Puri and Horst Sievert and Tang, {Gilbert H L} and Martin Andreas and {Von Bardeleben}, {Ralph Stephan} and Karl-Philipp Rommel and Guillem Muntan{\'e}-Carol and Mara Gavazzoni and Daniel Braun and Edith Lubos and Daniel Kalbacher and Connelly, {Kim A} and Jean-Michel Juliard and Claudia Harr and Giovanni Pedrazzini and Fran{\c c}ois Philippon and Joachim Schofer and Holger Thiele and Matthias Unterhuber and Dominique Himbert and Alc{\'a}zar, {Marina Ure{\~n}a} and Wild, {Mirjam G} and Ulrich Jorde and Stephan Windecker and Francesco Maisano and Leon, {Martin B} and Hahn, {Rebecca T} and Azeem Latib",
note = "Copyright {\textcopyright} 2023. Published by Elsevier Inc.",
year = "2023",
month = mar,
day = "27",
doi = "10.1016/j.jcin.2023.01.375",
language = "English",
volume = "16",
pages = "706--717",
journal = "JACC-CARDIOVASC INTE",
issn = "1936-8798",
publisher = "Elsevier Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Prognostic Value of Tricuspid Valve Gradient After Transcatheter Edge-to-Edge Repair: Insights From the TriValve Registry

AU - Coisne, Augustin

AU - Scotti, Andrea

AU - Taramasso, Maurizio

AU - Granada, Juan F

AU - Ludwig, Sebastian

AU - Rodés-Cabau, Josep

AU - Lurz, Philipp

AU - Hausleiter, Jörg

AU - Fam, Neil

AU - Kodali, Susheel K

AU - Pozzoli, Alberto

AU - Alessandrini, Hannes

AU - Biasco, Luigi

AU - Brochet, Eric

AU - Denti, Paolo

AU - Estevez-Loureiro, Rodrigo

AU - Frerker, Christian

AU - Ho, Edwin C

AU - Monivas, Vanessa

AU - Nickenig, Georg

AU - Praz, Fabien

AU - Puri, Rishi

AU - Sievert, Horst

AU - Tang, Gilbert H L

AU - Andreas, Martin

AU - Von Bardeleben, Ralph Stephan

AU - Rommel, Karl-Philipp

AU - Muntané-Carol, Guillem

AU - Gavazzoni, Mara

AU - Braun, Daniel

AU - Lubos, Edith

AU - Kalbacher, Daniel

AU - Connelly, Kim A

AU - Juliard, Jean-Michel

AU - Harr, Claudia

AU - Pedrazzini, Giovanni

AU - Philippon, François

AU - Schofer, Joachim

AU - Thiele, Holger

AU - Unterhuber, Matthias

AU - Himbert, Dominique

AU - Alcázar, Marina Ureña

AU - Wild, Mirjam G

AU - Jorde, Ulrich

AU - Windecker, Stephan

AU - Maisano, Francesco

AU - Leon, Martin B

AU - Hahn, Rebecca T

AU - Latib, Azeem

N1 - Copyright © 2023. Published by Elsevier Inc.

PY - 2023/3/27

Y1 - 2023/3/27

N2 - BACKGROUND: Data regarding the impact of the tricuspid valve gradient (TVG) after tricuspid transcatheter edge-to-edge repair (TEER) are scarce.OBJECTIVES: This study sought to evaluate the association between the mean TVG and clinical outcomes among patients who underwent tricuspid TEER for significant tricuspid regurgitation.METHODS: Patients with significant tricuspid regurgitation who underwent tricuspid TEER within the TriValve (International Multisite Transcatheter Tricuspid Valve Therapies) registry were divided into quartiles based on the mean TVG at discharge. The primary endpoint was the composite of all-cause mortality and heart failure hospitalization. Outcomes were assessed up to the 1-year follow-up.RESULTS: A total of 308 patients were included from 24 centers. Patients were divided into quartiles of the mean TVG as follows: quartile 1 (n = 77), 0.9 ± 0.3 mm Hg; quartile 2 (n = 115), 1.8 ± 0.3 mm Hg; quartile 3 (n = 65), 2.8 ± 0.3 mm Hg; and quartile 4 (n = 51), 4.7 ± 2.0 mm Hg. The baseline TVG and the number of implanted clips were associated with a higher post-TEER TVG. There was no significant difference across TVG quartiles in the 1-year composite endpoint (quartiles 1-4: 35%, 30%, 40%, and 34%, respectively; P = 0.60) or the proportion of patients in New York Heart Association class III to IV at the last follow-up (P = 0.63). The results were similar after adjustment for clinical and echocardiographic characteristics (composite endpoint quartile 4 vs quartile 1-quartile 3 adjusted HR: 1.05; 95% CI: 0.52-2.12; P = 0.88) or exploring post-TEER TVG as a continuous variable.CONCLUSIONS: In this retrospective analysis of the TriValve registry, an increased discharge TVG was not significantly associated with adverse outcomes after tricuspid TEER. These findings apply for the explored TVG range and up to the 1-year follow-up. Further investigations on higher gradients and longer follow-up are needed to better guide the intraprocedural decision-making process.

AB - BACKGROUND: Data regarding the impact of the tricuspid valve gradient (TVG) after tricuspid transcatheter edge-to-edge repair (TEER) are scarce.OBJECTIVES: This study sought to evaluate the association between the mean TVG and clinical outcomes among patients who underwent tricuspid TEER for significant tricuspid regurgitation.METHODS: Patients with significant tricuspid regurgitation who underwent tricuspid TEER within the TriValve (International Multisite Transcatheter Tricuspid Valve Therapies) registry were divided into quartiles based on the mean TVG at discharge. The primary endpoint was the composite of all-cause mortality and heart failure hospitalization. Outcomes were assessed up to the 1-year follow-up.RESULTS: A total of 308 patients were included from 24 centers. Patients were divided into quartiles of the mean TVG as follows: quartile 1 (n = 77), 0.9 ± 0.3 mm Hg; quartile 2 (n = 115), 1.8 ± 0.3 mm Hg; quartile 3 (n = 65), 2.8 ± 0.3 mm Hg; and quartile 4 (n = 51), 4.7 ± 2.0 mm Hg. The baseline TVG and the number of implanted clips were associated with a higher post-TEER TVG. There was no significant difference across TVG quartiles in the 1-year composite endpoint (quartiles 1-4: 35%, 30%, 40%, and 34%, respectively; P = 0.60) or the proportion of patients in New York Heart Association class III to IV at the last follow-up (P = 0.63). The results were similar after adjustment for clinical and echocardiographic characteristics (composite endpoint quartile 4 vs quartile 1-quartile 3 adjusted HR: 1.05; 95% CI: 0.52-2.12; P = 0.88) or exploring post-TEER TVG as a continuous variable.CONCLUSIONS: In this retrospective analysis of the TriValve registry, an increased discharge TVG was not significantly associated with adverse outcomes after tricuspid TEER. These findings apply for the explored TVG range and up to the 1-year follow-up. Further investigations on higher gradients and longer follow-up are needed to better guide the intraprocedural decision-making process.

U2 - 10.1016/j.jcin.2023.01.375

DO - 10.1016/j.jcin.2023.01.375

M3 - SCORING: Journal article

C2 - 36948892

VL - 16

SP - 706

EP - 717

JO - JACC-CARDIOVASC INTE

JF - JACC-CARDIOVASC INTE

SN - 1936-8798

IS - 6

ER -