Prognostic value of the pre-operative serum albumin to globulin ratio in patients with non-metastatic prostate cancer undergoing radical prostatectomy
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Prognostic value of the pre-operative serum albumin to globulin ratio in patients with non-metastatic prostate cancer undergoing radical prostatectomy. / Aydh, Abdulmajeed; Mori, Keiichiro; D'Andrea, David; Motlagh, Reza Sari; Abufaraj, Mohammad; Pradere, Benjamin; Mostafaei, Hadi; Laukhtina, Ekaterina; Quhal, Fahad; Karakiewicz, Pierre I; Luzzago, Stefano; Briganti, Alberto; Trinh, Quoc-Dien; Parizi, Mehdi Kardoust; Tilki, Derya; Enikeev, Dmitry V; Shariat, Shahrokh F.
In: INT J CLIN ONCOL, Vol. 26, No. 9, 09.2021, p. 1729-1735.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Prognostic value of the pre-operative serum albumin to globulin ratio in patients with non-metastatic prostate cancer undergoing radical prostatectomy
AU - Aydh, Abdulmajeed
AU - Mori, Keiichiro
AU - D'Andrea, David
AU - Motlagh, Reza Sari
AU - Abufaraj, Mohammad
AU - Pradere, Benjamin
AU - Mostafaei, Hadi
AU - Laukhtina, Ekaterina
AU - Quhal, Fahad
AU - Karakiewicz, Pierre I
AU - Luzzago, Stefano
AU - Briganti, Alberto
AU - Trinh, Quoc-Dien
AU - Parizi, Mehdi Kardoust
AU - Tilki, Derya
AU - Enikeev, Dmitry V
AU - Shariat, Shahrokh F
N1 - © 2021. The Author(s).
PY - 2021/9
Y1 - 2021/9
N2 - PURPOSE: To evaluate the potential predictive value of the preoperative serum albumin to globulin ratio (AGR) for oncological outcomes in patients treated with radical prostatectomy (RP) for clinically non-metastatic prostate cancer (PCa).METHODS: Pre-operative AGR was assessed in a multi-institutional cohort of 6041 patients treated with RP. Logistic regression analyses were performed to assess the association of the AGR with advanced disease. We performed Cox regression analyses to determine the relationship between AGR and biochemical recurrence (BCR).RESULTS: The optimal cut-off value was determined to be 1.31 according to receiver operating curve analysis. Compared to patients with a higher AGR, those with a lower preoperative AGR had worse BCR-free survival (P < 0.01) in the Kaplan-Meier analysis. Pre- and post-operative multivariable models that adjusted for the effects of established clinicopathologic features, confirmed its independent association with BCR [hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.31-1.75, P < 0.01, HR 1.55, 95% CI 1.34-1.79, P < 0.01, respectively]. However, the addition of AGR to established prognostic models did not improve their discrimination.CONCLUSION: While AGR is significantly associated with BCR, in the present study, the clinical impact of AGR was not large enough to affect patient management. Longer follow-up is necessary to observe the true effect of AGR.
AB - PURPOSE: To evaluate the potential predictive value of the preoperative serum albumin to globulin ratio (AGR) for oncological outcomes in patients treated with radical prostatectomy (RP) for clinically non-metastatic prostate cancer (PCa).METHODS: Pre-operative AGR was assessed in a multi-institutional cohort of 6041 patients treated with RP. Logistic regression analyses were performed to assess the association of the AGR with advanced disease. We performed Cox regression analyses to determine the relationship between AGR and biochemical recurrence (BCR).RESULTS: The optimal cut-off value was determined to be 1.31 according to receiver operating curve analysis. Compared to patients with a higher AGR, those with a lower preoperative AGR had worse BCR-free survival (P < 0.01) in the Kaplan-Meier analysis. Pre- and post-operative multivariable models that adjusted for the effects of established clinicopathologic features, confirmed its independent association with BCR [hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.31-1.75, P < 0.01, HR 1.55, 95% CI 1.34-1.79, P < 0.01, respectively]. However, the addition of AGR to established prognostic models did not improve their discrimination.CONCLUSION: While AGR is significantly associated with BCR, in the present study, the clinical impact of AGR was not large enough to affect patient management. Longer follow-up is necessary to observe the true effect of AGR.
U2 - 10.1007/s10147-021-01952-6
DO - 10.1007/s10147-021-01952-6
M3 - SCORING: Journal article
C2 - 34184136
VL - 26
SP - 1729
EP - 1735
JO - INT J CLIN ONCOL
JF - INT J CLIN ONCOL
SN - 1341-9625
IS - 9
ER -