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Prognostic Value of Serum and Ascites Levels of Estradiol, FSH, LH and Prolactin in Ovarian Cancer.

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Prognostic Value of Serum and Ascites Levels of Estradiol, FSH, LH and Prolactin in Ovarian Cancer. / Chen, Frank Chih-Kang; Oskay-Ozcelik, Guelten; Bühling, Kai J.; Köpstein, Uta; Mentze, Monika; Lichtenegger, Werner; Sehouli, Jalid.

In: ANTICANCER RES, Vol. 29, No. 5, 5, 2009, p. 1575-1578.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Chen, FC-K, Oskay-Ozcelik, G, Bühling, KJ, Köpstein, U, Mentze, M, Lichtenegger, W & Sehouli, J 2009, 'Prognostic Value of Serum and Ascites Levels of Estradiol, FSH, LH and Prolactin in Ovarian Cancer.', ANTICANCER RES, vol. 29, no. 5, 5, pp. 1575-1578. <http://www.ncbi.nlm.nih.gov/pubmed/19443368?dopt=Citation>

APA

Chen, F. C-K., Oskay-Ozcelik, G., Bühling, K. J., Köpstein, U., Mentze, M., Lichtenegger, W., & Sehouli, J. (2009). Prognostic Value of Serum and Ascites Levels of Estradiol, FSH, LH and Prolactin in Ovarian Cancer. ANTICANCER RES, 29(5), 1575-1578. [5]. http://www.ncbi.nlm.nih.gov/pubmed/19443368?dopt=Citation

Vancouver

Chen FC-K, Oskay-Ozcelik G, Bühling KJ, Köpstein U, Mentze M, Lichtenegger W et al. Prognostic Value of Serum and Ascites Levels of Estradiol, FSH, LH and Prolactin in Ovarian Cancer. ANTICANCER RES. 2009;29(5):1575-1578. 5.

Bibtex

@article{4232355cc28143c78622344da4a1d324,
title = "Prognostic Value of Serum and Ascites Levels of Estradiol, FSH, LH and Prolactin in Ovarian Cancer.",
abstract = "The aim of this study was to investigate the influence of sex hormone levels on tumor biology and patients' outcome in ovarian cancer. PATIENTS AND METHODS: One hundred and six patients with ovarian cancer were enrolled into this prospective study. Serum and ascites samples were obtained intraoperatively. Concentrations of estradiol, FSH, LH and prolactin were measured and correlated with parameters of tumor biology, such as FIGO stage, tumor spread and postoperative tumor residual mass. Patients with primary ovarian cancer were compared to patients with recurrent disease. Influence factors on progression-free survival and overall survival were analyzed using the Kaplan-Meyer method. RESULTS: Serum FSH concentrations were significantly higher and estradiol concentrations in ascites were significantly lower in patients with recurrent disease. According the multivariate analysis, only FSH level in ascites was seen to be an independent prognostic factor for patients' survival. CONCLUSION: High level of FSH in the ascites provides prognostic information in patients with ovarian cancer and is inversely correlated with patients' survival.",
author = "Chen, {Frank Chih-Kang} and Guelten Oskay-Ozcelik and B{\"u}hling, {Kai J.} and Uta K{\"o}pstein and Monika Mentze and Werner Lichtenegger and Jalid Sehouli",
year = "2009",
language = "Deutsch",
volume = "29",
pages = "1575--1578",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5",

}

RIS

TY - JOUR

T1 - Prognostic Value of Serum and Ascites Levels of Estradiol, FSH, LH and Prolactin in Ovarian Cancer.

AU - Chen, Frank Chih-Kang

AU - Oskay-Ozcelik, Guelten

AU - Bühling, Kai J.

AU - Köpstein, Uta

AU - Mentze, Monika

AU - Lichtenegger, Werner

AU - Sehouli, Jalid

PY - 2009

Y1 - 2009

N2 - The aim of this study was to investigate the influence of sex hormone levels on tumor biology and patients' outcome in ovarian cancer. PATIENTS AND METHODS: One hundred and six patients with ovarian cancer were enrolled into this prospective study. Serum and ascites samples were obtained intraoperatively. Concentrations of estradiol, FSH, LH and prolactin were measured and correlated with parameters of tumor biology, such as FIGO stage, tumor spread and postoperative tumor residual mass. Patients with primary ovarian cancer were compared to patients with recurrent disease. Influence factors on progression-free survival and overall survival were analyzed using the Kaplan-Meyer method. RESULTS: Serum FSH concentrations were significantly higher and estradiol concentrations in ascites were significantly lower in patients with recurrent disease. According the multivariate analysis, only FSH level in ascites was seen to be an independent prognostic factor for patients' survival. CONCLUSION: High level of FSH in the ascites provides prognostic information in patients with ovarian cancer and is inversely correlated with patients' survival.

AB - The aim of this study was to investigate the influence of sex hormone levels on tumor biology and patients' outcome in ovarian cancer. PATIENTS AND METHODS: One hundred and six patients with ovarian cancer were enrolled into this prospective study. Serum and ascites samples were obtained intraoperatively. Concentrations of estradiol, FSH, LH and prolactin were measured and correlated with parameters of tumor biology, such as FIGO stage, tumor spread and postoperative tumor residual mass. Patients with primary ovarian cancer were compared to patients with recurrent disease. Influence factors on progression-free survival and overall survival were analyzed using the Kaplan-Meyer method. RESULTS: Serum FSH concentrations were significantly higher and estradiol concentrations in ascites were significantly lower in patients with recurrent disease. According the multivariate analysis, only FSH level in ascites was seen to be an independent prognostic factor for patients' survival. CONCLUSION: High level of FSH in the ascites provides prognostic information in patients with ovarian cancer and is inversely correlated with patients' survival.

M3 - SCORING: Zeitschriftenaufsatz

VL - 29

SP - 1575

EP - 1578

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 5

M1 - 5

ER -