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Prognostic value of positive histological margins in patients with pancreatic head ductal adenocarcinoma and lymph node involvement: an international multicentric study

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Prognostic value of positive histological margins in patients with pancreatic head ductal adenocarcinoma and lymph node involvement: an international multicentric study. / Joliat, Gaëtan-Romain; Allemann, Pierre; Labgaa, Ismail; Sulzer, Jesse; Vrochides, Dionisios; Zerbi, Alessandro; Nappo, Gennaro; Perinel, Julie; Adham, Mustapha; Nentwich, Michael F; Izbicki, Jakob R; Demartines, Nicolas; Schäfer, Markus.

In: HPB, Vol. 23, No. 3, 03.2021, p. 379-386.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Joliat, G-R, Allemann, P, Labgaa, I, Sulzer, J, Vrochides, D, Zerbi, A, Nappo, G, Perinel, J, Adham, M, Nentwich, MF, Izbicki, JR, Demartines, N & Schäfer, M 2021, 'Prognostic value of positive histological margins in patients with pancreatic head ductal adenocarcinoma and lymph node involvement: an international multicentric study', HPB, vol. 23, no. 3, pp. 379-386. https://doi.org/10.1016/j.hpb.2020.07.008

APA

Joliat, G-R., Allemann, P., Labgaa, I., Sulzer, J., Vrochides, D., Zerbi, A., Nappo, G., Perinel, J., Adham, M., Nentwich, M. F., Izbicki, J. R., Demartines, N., & Schäfer, M. (2021). Prognostic value of positive histological margins in patients with pancreatic head ductal adenocarcinoma and lymph node involvement: an international multicentric study. HPB, 23(3), 379-386. https://doi.org/10.1016/j.hpb.2020.07.008

Vancouver

Joliat G-R, Allemann P, Labgaa I, Sulzer J, Vrochides D, Zerbi A et al. Prognostic value of positive histological margins in patients with pancreatic head ductal adenocarcinoma and lymph node involvement: an international multicentric study. HPB. 2021 Mar;23(3):379-386. https://doi.org/10.1016/j.hpb.2020.07.008

Bibtex

@article{5ac22cd20ae9462c98043ce4e0942b9c,
title = "Prognostic value of positive histological margins in patients with pancreatic head ductal adenocarcinoma and lymph node involvement: an international multicentric study",
abstract = "BACKGROUND: Resection margin status and lymph node (LN) involvement are known prognostic factors for patients who undergo pancreatoduodenectomy for pancreatic ductal adenocarcinoma (PDAC). This study aimed to compare overall survival (OS) and disease-free survival (DFS) by resection margin status in patients with PDAC and LN involvement.METHODS: A retrospective international multicentric study was performed including four Western centers. Multivariable Cox analysis was performed to identify prognostic factors of OS and DFS. Median OS and DFS were calculated using Kaplan-Meier curves and compared using log-rank tests.RESULTS: A cohort of 814 PDAC patients with pancreatoduodenectomy were analyzed. A total of 651 patients had LN involvement (80%). On multivariable analysis R1 resection was not an independent factor of worse OS and DFS in patients with LN involvement (HR 1.1, p = 0.565; HR 1.2, p = 0.174). Only tumor size, grade, and adjuvant chemotherapy were associated with OS and DFS. Median OS and DFS were similar between patients with R0 and R1 resections (23 vs. 20 months, p = 0.196; 15 vs. 14 months, p = 0.080).CONCLUSION: Resection status was not identified as predictor of OS or DFS in PDAC patients with LN involvement. Extensive surgery to achieve R0 resection in such patients might not influence the disease course.",
author = "Ga{\"e}tan-Romain Joliat and Pierre Allemann and Ismail Labgaa and Jesse Sulzer and Dionisios Vrochides and Alessandro Zerbi and Gennaro Nappo and Julie Perinel and Mustapha Adham and Nentwich, {Michael F} and Izbicki, {Jakob R} and Nicolas Demartines and Markus Sch{\"a}fer",
note = "Copyright {\textcopyright} 2020 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.",
year = "2021",
month = mar,
doi = "10.1016/j.hpb.2020.07.008",
language = "English",
volume = "23",
pages = "379--386",
journal = "HPB",
issn = "1365-182X",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Prognostic value of positive histological margins in patients with pancreatic head ductal adenocarcinoma and lymph node involvement: an international multicentric study

AU - Joliat, Gaëtan-Romain

AU - Allemann, Pierre

AU - Labgaa, Ismail

AU - Sulzer, Jesse

AU - Vrochides, Dionisios

AU - Zerbi, Alessandro

AU - Nappo, Gennaro

AU - Perinel, Julie

AU - Adham, Mustapha

AU - Nentwich, Michael F

AU - Izbicki, Jakob R

AU - Demartines, Nicolas

AU - Schäfer, Markus

N1 - Copyright © 2020 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.

PY - 2021/3

Y1 - 2021/3

N2 - BACKGROUND: Resection margin status and lymph node (LN) involvement are known prognostic factors for patients who undergo pancreatoduodenectomy for pancreatic ductal adenocarcinoma (PDAC). This study aimed to compare overall survival (OS) and disease-free survival (DFS) by resection margin status in patients with PDAC and LN involvement.METHODS: A retrospective international multicentric study was performed including four Western centers. Multivariable Cox analysis was performed to identify prognostic factors of OS and DFS. Median OS and DFS were calculated using Kaplan-Meier curves and compared using log-rank tests.RESULTS: A cohort of 814 PDAC patients with pancreatoduodenectomy were analyzed. A total of 651 patients had LN involvement (80%). On multivariable analysis R1 resection was not an independent factor of worse OS and DFS in patients with LN involvement (HR 1.1, p = 0.565; HR 1.2, p = 0.174). Only tumor size, grade, and adjuvant chemotherapy were associated with OS and DFS. Median OS and DFS were similar between patients with R0 and R1 resections (23 vs. 20 months, p = 0.196; 15 vs. 14 months, p = 0.080).CONCLUSION: Resection status was not identified as predictor of OS or DFS in PDAC patients with LN involvement. Extensive surgery to achieve R0 resection in such patients might not influence the disease course.

AB - BACKGROUND: Resection margin status and lymph node (LN) involvement are known prognostic factors for patients who undergo pancreatoduodenectomy for pancreatic ductal adenocarcinoma (PDAC). This study aimed to compare overall survival (OS) and disease-free survival (DFS) by resection margin status in patients with PDAC and LN involvement.METHODS: A retrospective international multicentric study was performed including four Western centers. Multivariable Cox analysis was performed to identify prognostic factors of OS and DFS. Median OS and DFS were calculated using Kaplan-Meier curves and compared using log-rank tests.RESULTS: A cohort of 814 PDAC patients with pancreatoduodenectomy were analyzed. A total of 651 patients had LN involvement (80%). On multivariable analysis R1 resection was not an independent factor of worse OS and DFS in patients with LN involvement (HR 1.1, p = 0.565; HR 1.2, p = 0.174). Only tumor size, grade, and adjuvant chemotherapy were associated with OS and DFS. Median OS and DFS were similar between patients with R0 and R1 resections (23 vs. 20 months, p = 0.196; 15 vs. 14 months, p = 0.080).CONCLUSION: Resection status was not identified as predictor of OS or DFS in PDAC patients with LN involvement. Extensive surgery to achieve R0 resection in such patients might not influence the disease course.

U2 - 10.1016/j.hpb.2020.07.008

DO - 10.1016/j.hpb.2020.07.008

M3 - SCORING: Journal article

C2 - 32782224

VL - 23

SP - 379

EP - 386

JO - HPB

JF - HPB

SN - 1365-182X

IS - 3

ER -