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Prognostic value of cell cycle and apoptosis regulatory proteins in mismatch repair-proficient colorectal cancer: a tissue microarray-based approach.

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Prognostic value of cell cycle and apoptosis regulatory proteins in mismatch repair-proficient colorectal cancer: a tissue microarray-based approach. / Tornillo, Luigi; Lugli, Alessandro; Zlobec, Inti; Willi, Niels; Glatz, Kathrin; Lehmann, Frank; Spichtin, Hans-Peter; Maurer, Robert; Stoios, Dimitra; Sauter, Guido; Terracciano, Luigi.

In: AM J CLIN PATHOL, Vol. 127, No. 1, 1, 2007, p. 114-123.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tornillo, L, Lugli, A, Zlobec, I, Willi, N, Glatz, K, Lehmann, F, Spichtin, H-P, Maurer, R, Stoios, D, Sauter, G & Terracciano, L 2007, 'Prognostic value of cell cycle and apoptosis regulatory proteins in mismatch repair-proficient colorectal cancer: a tissue microarray-based approach.', AM J CLIN PATHOL, vol. 127, no. 1, 1, pp. 114-123. <http://www.ncbi.nlm.nih.gov/pubmed/17145638?dopt=Citation>

APA

Tornillo, L., Lugli, A., Zlobec, I., Willi, N., Glatz, K., Lehmann, F., Spichtin, H-P., Maurer, R., Stoios, D., Sauter, G., & Terracciano, L. (2007). Prognostic value of cell cycle and apoptosis regulatory proteins in mismatch repair-proficient colorectal cancer: a tissue microarray-based approach. AM J CLIN PATHOL, 127(1), 114-123. [1]. http://www.ncbi.nlm.nih.gov/pubmed/17145638?dopt=Citation

Vancouver

Tornillo L, Lugli A, Zlobec I, Willi N, Glatz K, Lehmann F et al. Prognostic value of cell cycle and apoptosis regulatory proteins in mismatch repair-proficient colorectal cancer: a tissue microarray-based approach. AM J CLIN PATHOL. 2007;127(1):114-123. 1.

Bibtex

@article{ea1914336a7a4bae8aa8673f6a248a6f,
title = "Prognostic value of cell cycle and apoptosis regulatory proteins in mismatch repair-proficient colorectal cancer: a tissue microarray-based approach.",
abstract = "Cell cycle and apoptosis regulatory proteins are markers of tumor progression in colorectal cancer. In a series of 1,274 mismatch repair-proficient colorectal cancers, immunohistochemical analysis of p21, p27, p53, and bcl-2 expression was performed using the tissue microarray technique.In univariate analysis, p21 expression was associated with tumor location and pN0; p27 expression with tumor location, lower tumor grade, early pT, and pN; p53 expression with tumor location; and bcl-2 with early pT and pN. Expression of p27 identified subgroups with worse prognosis in pT3 N0 and pT3 N+ patients. None of the 4 tumor markers were independent prognostic indicators of survival. The multimarker phenotypes p21/p27/p53 and p21/p27/bcl-2 were associated with survival.In mismatch repair-proficient colorectal cancer, p27 expression is associated with a better prognosis, and pT, pN, and vascular invasion are independent prognostic factors. In addition, multimarker phenotypes are useful to identify colorectal cancer subgroups with different prognoses.",
author = "Luigi Tornillo and Alessandro Lugli and Inti Zlobec and Niels Willi and Kathrin Glatz and Frank Lehmann and Hans-Peter Spichtin and Robert Maurer and Dimitra Stoios and Guido Sauter and Luigi Terracciano",
year = "2007",
language = "Deutsch",
volume = "127",
pages = "114--123",
journal = "AM J CLIN PATHOL",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "1",

}

RIS

TY - JOUR

T1 - Prognostic value of cell cycle and apoptosis regulatory proteins in mismatch repair-proficient colorectal cancer: a tissue microarray-based approach.

AU - Tornillo, Luigi

AU - Lugli, Alessandro

AU - Zlobec, Inti

AU - Willi, Niels

AU - Glatz, Kathrin

AU - Lehmann, Frank

AU - Spichtin, Hans-Peter

AU - Maurer, Robert

AU - Stoios, Dimitra

AU - Sauter, Guido

AU - Terracciano, Luigi

PY - 2007

Y1 - 2007

N2 - Cell cycle and apoptosis regulatory proteins are markers of tumor progression in colorectal cancer. In a series of 1,274 mismatch repair-proficient colorectal cancers, immunohistochemical analysis of p21, p27, p53, and bcl-2 expression was performed using the tissue microarray technique.In univariate analysis, p21 expression was associated with tumor location and pN0; p27 expression with tumor location, lower tumor grade, early pT, and pN; p53 expression with tumor location; and bcl-2 with early pT and pN. Expression of p27 identified subgroups with worse prognosis in pT3 N0 and pT3 N+ patients. None of the 4 tumor markers were independent prognostic indicators of survival. The multimarker phenotypes p21/p27/p53 and p21/p27/bcl-2 were associated with survival.In mismatch repair-proficient colorectal cancer, p27 expression is associated with a better prognosis, and pT, pN, and vascular invasion are independent prognostic factors. In addition, multimarker phenotypes are useful to identify colorectal cancer subgroups with different prognoses.

AB - Cell cycle and apoptosis regulatory proteins are markers of tumor progression in colorectal cancer. In a series of 1,274 mismatch repair-proficient colorectal cancers, immunohistochemical analysis of p21, p27, p53, and bcl-2 expression was performed using the tissue microarray technique.In univariate analysis, p21 expression was associated with tumor location and pN0; p27 expression with tumor location, lower tumor grade, early pT, and pN; p53 expression with tumor location; and bcl-2 with early pT and pN. Expression of p27 identified subgroups with worse prognosis in pT3 N0 and pT3 N+ patients. None of the 4 tumor markers were independent prognostic indicators of survival. The multimarker phenotypes p21/p27/p53 and p21/p27/bcl-2 were associated with survival.In mismatch repair-proficient colorectal cancer, p27 expression is associated with a better prognosis, and pT, pN, and vascular invasion are independent prognostic factors. In addition, multimarker phenotypes are useful to identify colorectal cancer subgroups with different prognoses.

M3 - SCORING: Zeitschriftenaufsatz

VL - 127

SP - 114

EP - 123

JO - AM J CLIN PATHOL

JF - AM J CLIN PATHOL

SN - 0002-9173

IS - 1

M1 - 1

ER -