Research ExplorerPublicationsPrognostic value and link to atrial fibrillation of soluble ...

Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients

Standard

Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients. / Nowak, Albina; Friedrich, Björn; Artunc, Ferruh; Serra, Andreas L; Breidthardt, Tobias; Twerenbold, Raphael; Peter, Myriam; Mueller, Christian.

In: PLOS ONE, Vol. 9, No. 7, 2014, p. e100688.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Nowak, A, Friedrich, B, Artunc, F, Serra, AL, Breidthardt, T, Twerenbold, R, Peter, M & Mueller, C 2014, 'Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients', PLOS ONE, vol. 9, no. 7, pp. e100688. https://doi.org/10.1371/journal.pone.0100688

APA

Nowak, A., Friedrich, B., Artunc, F., Serra, A. L., Breidthardt, T., Twerenbold, R., Peter, M., & Mueller, C. (2014). Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients. PLOS ONE, 9(7), e100688. https://doi.org/10.1371/journal.pone.0100688

Vancouver

Nowak A, Friedrich B, Artunc F, Serra AL, Breidthardt T, Twerenbold R et al. Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients. PLOS ONE. 2014;9(7):e100688. https://doi.org/10.1371/journal.pone.0100688

Bibtex

@article{e3f7d1f042c843bc886c618a43ebde59,
title = "Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients",
abstract = "Deranged calcium-phosphate metabolism contributes to the burden of morbidity and mortality in dialysis patients. This study aimed to assess the association of the phosphaturic hormone fibroblast growth factor 23 (FGF23) and soluble Klotho with all-cause mortality. We measured soluble Klotho and FGF23 levels at enrolment and two weeks later in 239 prevalent hemodialysis patients. The primary hypothesis was that low Klotho and high FGF23 are associated with increased mortality. The association between Klotho and atrial fibrillation (AF) at baseline was explored as secondary outcome. AF was defined as presence of paroxysmal, persistent or permanent AF. During a median follow-up of 924 days, 59 (25%) patients died from any cause. Lower Klotho levels were not associated with mortality in a multivariable adjusted analysis when examined either on a continuous scale (HR 1.25 per SD increase, 95% CI 0.84-1.86) or in tertiles, with tertile 1 as the reference category (HR for tertile two 0.65, 95% CI 0.26-1.64; HR for tertile three 2.18, 95% CI 0.91-2.23). Higher Klotho levels were associated with the absence of AF in a muItivariable logistic regression analysis (OR 0.66 per SD increase, 95% CI 0.41-1.00). Higher FGF23 levels were associated with mortality risk in a multivariable adjusted analysis when examined either on a continuous scale (HR 1.45 per SD increase, 95% CI 1.05-1.99) or in tertiles, with the tertile 1 as the reference category (HR for tertile two 1.63, 95% CI 0.64-4.14; HR for tertile three 3.91, 95% CI 1.28-12.20). FGF23 but not Klotho levels are associated with mortality in hemodialysis patients. Klotho may be protective against AF. ",
keywords = "Aged, Aged, 80 and over, Atrial Fibrillation/blood, Disease-Free Survival, Female, Fibroblast Growth Factor-23, Fibroblast Growth Factors/blood, Glucuronidase/blood, Humans, Klotho Proteins, Male, Middle Aged, Prospective Studies, Renal Dialysis, Survival Rate",
author = "Albina Nowak and Bj{\"o}rn Friedrich and Ferruh Artunc and Serra, {Andreas L} and Tobias Breidthardt and Raphael Twerenbold and Myriam Peter and Christian Mueller",
year = "2014",
doi = "10.1371/journal.pone.0100688",
language = "English",
volume = "9",
pages = "e100688",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients

AU - Nowak, Albina

AU - Friedrich, Björn

AU - Artunc, Ferruh

AU - Serra, Andreas L

AU - Breidthardt, Tobias

AU - Twerenbold, Raphael

AU - Peter, Myriam

AU - Mueller, Christian

PY - 2014

Y1 - 2014

N2 - Deranged calcium-phosphate metabolism contributes to the burden of morbidity and mortality in dialysis patients. This study aimed to assess the association of the phosphaturic hormone fibroblast growth factor 23 (FGF23) and soluble Klotho with all-cause mortality. We measured soluble Klotho and FGF23 levels at enrolment and two weeks later in 239 prevalent hemodialysis patients. The primary hypothesis was that low Klotho and high FGF23 are associated with increased mortality. The association between Klotho and atrial fibrillation (AF) at baseline was explored as secondary outcome. AF was defined as presence of paroxysmal, persistent or permanent AF. During a median follow-up of 924 days, 59 (25%) patients died from any cause. Lower Klotho levels were not associated with mortality in a multivariable adjusted analysis when examined either on a continuous scale (HR 1.25 per SD increase, 95% CI 0.84-1.86) or in tertiles, with tertile 1 as the reference category (HR for tertile two 0.65, 95% CI 0.26-1.64; HR for tertile three 2.18, 95% CI 0.91-2.23). Higher Klotho levels were associated with the absence of AF in a muItivariable logistic regression analysis (OR 0.66 per SD increase, 95% CI 0.41-1.00). Higher FGF23 levels were associated with mortality risk in a multivariable adjusted analysis when examined either on a continuous scale (HR 1.45 per SD increase, 95% CI 1.05-1.99) or in tertiles, with the tertile 1 as the reference category (HR for tertile two 1.63, 95% CI 0.64-4.14; HR for tertile three 3.91, 95% CI 1.28-12.20). FGF23 but not Klotho levels are associated with mortality in hemodialysis patients. Klotho may be protective against AF.

AB - Deranged calcium-phosphate metabolism contributes to the burden of morbidity and mortality in dialysis patients. This study aimed to assess the association of the phosphaturic hormone fibroblast growth factor 23 (FGF23) and soluble Klotho with all-cause mortality. We measured soluble Klotho and FGF23 levels at enrolment and two weeks later in 239 prevalent hemodialysis patients. The primary hypothesis was that low Klotho and high FGF23 are associated with increased mortality. The association between Klotho and atrial fibrillation (AF) at baseline was explored as secondary outcome. AF was defined as presence of paroxysmal, persistent or permanent AF. During a median follow-up of 924 days, 59 (25%) patients died from any cause. Lower Klotho levels were not associated with mortality in a multivariable adjusted analysis when examined either on a continuous scale (HR 1.25 per SD increase, 95% CI 0.84-1.86) or in tertiles, with tertile 1 as the reference category (HR for tertile two 0.65, 95% CI 0.26-1.64; HR for tertile three 2.18, 95% CI 0.91-2.23). Higher Klotho levels were associated with the absence of AF in a muItivariable logistic regression analysis (OR 0.66 per SD increase, 95% CI 0.41-1.00). Higher FGF23 levels were associated with mortality risk in a multivariable adjusted analysis when examined either on a continuous scale (HR 1.45 per SD increase, 95% CI 1.05-1.99) or in tertiles, with the tertile 1 as the reference category (HR for tertile two 1.63, 95% CI 0.64-4.14; HR for tertile three 3.91, 95% CI 1.28-12.20). FGF23 but not Klotho levels are associated with mortality in hemodialysis patients. Klotho may be protective against AF.

KW - Aged

KW - Aged, 80 and over

KW - Atrial Fibrillation/blood

KW - Disease-Free Survival

KW - Female

KW - Fibroblast Growth Factor-23

KW - Fibroblast Growth Factors/blood

KW - Glucuronidase/blood

KW - Humans

KW - Klotho Proteins

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Renal Dialysis

KW - Survival Rate

U2 - 10.1371/journal.pone.0100688

DO - 10.1371/journal.pone.0100688

M3 - SCORING: Journal article

C2 - 24991914

VL - 9

SP - e100688

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 7

ER -