Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck.
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Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck. / Knecht, Rainald; Elez, R; Oechler, M; Solbach, C; von Ilberg, C; Strebhardt, K.
In: CANCER RES, Vol. 59, No. 12, 12, 1999, p. 2794-2797.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck.
AU - Knecht, Rainald
AU - Elez, R
AU - Oechler, M
AU - Solbach, C
AU - von Ilberg, C
AU - Strebhardt, K
PY - 1999
Y1 - 1999
N2 - Previously, we demonstrated that the mammalian polo-like kinase (PLK), which participates in the regulation of the cell cycle, is a novel marker of cellular proliferation. Because current prognostic tools for the evaluation of patients with head and neck squamous cell cancer (HNSCC) need to be improved, we analyzed 89 patients and found elevated PLK expression in most tumors. Nodal stage as a crucial prognostic factor in HNSCC also correlated to PLK transcript levels (P = 0.0043). A Kaplan-Meier analysis showed that HNSCC patients with moderate versus high PLK expression survived significantly longer (5-year survival rates, 43% versus 12%; P = 0.0047). Interestingly, a combination of nodal stage and PLK expression contributed to discriminate patients with a better prognosis in the pN(0/1) and pN(2/3) groups, which could improve the definition of a suitable therapy.
AB - Previously, we demonstrated that the mammalian polo-like kinase (PLK), which participates in the regulation of the cell cycle, is a novel marker of cellular proliferation. Because current prognostic tools for the evaluation of patients with head and neck squamous cell cancer (HNSCC) need to be improved, we analyzed 89 patients and found elevated PLK expression in most tumors. Nodal stage as a crucial prognostic factor in HNSCC also correlated to PLK transcript levels (P = 0.0043). A Kaplan-Meier analysis showed that HNSCC patients with moderate versus high PLK expression survived significantly longer (5-year survival rates, 43% versus 12%; P = 0.0047). Interestingly, a combination of nodal stage and PLK expression contributed to discriminate patients with a better prognosis in the pN(0/1) and pN(2/3) groups, which could improve the definition of a suitable therapy.
M3 - SCORING: Zeitschriftenaufsatz
VL - 59
SP - 2794
EP - 2797
JO - CANCER RES
JF - CANCER RES
SN - 0008-5472
IS - 12
M1 - 12
ER -
