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Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation

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Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation. / Bondong, S; Kiefel, H; Hielscher, T; Zeimet, A G; Zeillinger, R; Pils, D; Schuster, E; Castillo-Tong, D C; Cadron, I; Vergote, I; Braicu, I; Sehouli, J; Mahner, S; Fogel, M; Altevogt, P.

In: ANN ONCOL, Vol. 23, No. 7, 01.07.2012, p. 1795-802.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bondong, S, Kiefel, H, Hielscher, T, Zeimet, AG, Zeillinger, R, Pils, D, Schuster, E, Castillo-Tong, DC, Cadron, I, Vergote, I, Braicu, I, Sehouli, J, Mahner, S, Fogel, M & Altevogt, P 2012, 'Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation', ANN ONCOL, vol. 23, no. 7, pp. 1795-802. https://doi.org/10.1093/annonc/mdr568

APA

Bondong, S., Kiefel, H., Hielscher, T., Zeimet, A. G., Zeillinger, R., Pils, D., Schuster, E., Castillo-Tong, D. C., Cadron, I., Vergote, I., Braicu, I., Sehouli, J., Mahner, S., Fogel, M., & Altevogt, P. (2012). Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation. ANN ONCOL, 23(7), 1795-802. https://doi.org/10.1093/annonc/mdr568

Vancouver

Bondong S, Kiefel H, Hielscher T, Zeimet AG, Zeillinger R, Pils D et al. Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation. ANN ONCOL. 2012 Jul 1;23(7):1795-802. https://doi.org/10.1093/annonc/mdr568

Bibtex

@article{b074eebf2e4a4eedbc8a393264d83765,
title = "Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation",
abstract = "BACKGROUND: Overexpression of L1-cell adhesion molecule (L1CAM) has been observed for various carcinomas and correlates with poor prognosis and late-stage disease. In vitro, L1CAM enhances proliferation, cell migration, adhesion and chemoresistance. We tested L1CAM and interleukin-1 beta (IL-1β) expression in tumor samples and ascitic fluid from ovarian carcinoma patients to examine its role as a prognostic marker.PATIENTS AND METHODS: We investigated tumor samples and ascitic fluid from 232 serous ovarian carcinoma patients for L1CAM by enzyme-linked immunosorbent assay. L1CAM expression was correlated with pathoclinical parameters and patients' outcome. IL-1β levels were measured in tumor cell lysates. Ovarian cancer cell lines were analyzed for the contribution of L1CAM to IL-1β production and nuclear factor 'kappa-light-chain-enhancer' of activated B-cells (NF-κB) activation.RESULTS: We observed that L1CAM-expressing tumors show a highly invasive phenotype associated with restricted tumor resectability at primary debulking surgery and increased lymphogenic spread. Soluble L1CAM proved to be a marker for poor progression-free survival and chemoresistance. In ovarian carcinoma cell lines, the specific knock-down of L1CAM reduces IL-1β expression and NF-κB activity.CONCLUSIONS: L1CAM expression contributes to the invasive and metastatic phenotype of serous ovarian carcinoma. L1CAM expression and shedding in the tumor microenvironment could contribute to enhanced invasion and tumor progression through increased IL-1β production and NF-κB activation.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Ascitic Fluid, Carcinoma, Cell Line, Tumor, Disease-Free Survival, Female, Humans, Interleukin-1beta, Kaplan-Meier Estimate, Lymphatic Metastasis, Middle Aged, Multivariate Analysis, NF-kappa B, Neoplasm Invasiveness, Neural Cell Adhesion Molecule L1, Ovarian Neoplasms, Phenotype, Prognosis, Young Adult",
author = "S Bondong and H Kiefel and T Hielscher and Zeimet, {A G} and R Zeillinger and D Pils and E Schuster and Castillo-Tong, {D C} and I Cadron and I Vergote and I Braicu and J Sehouli and S Mahner and M Fogel and P Altevogt",
year = "2012",
month = jul,
day = "1",
doi = "10.1093/annonc/mdr568",
language = "English",
volume = "23",
pages = "1795--802",
journal = "ANN ONCOL",
issn = "0923-7534",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation

AU - Bondong, S

AU - Kiefel, H

AU - Hielscher, T

AU - Zeimet, A G

AU - Zeillinger, R

AU - Pils, D

AU - Schuster, E

AU - Castillo-Tong, D C

AU - Cadron, I

AU - Vergote, I

AU - Braicu, I

AU - Sehouli, J

AU - Mahner, S

AU - Fogel, M

AU - Altevogt, P

PY - 2012/7/1

Y1 - 2012/7/1

N2 - BACKGROUND: Overexpression of L1-cell adhesion molecule (L1CAM) has been observed for various carcinomas and correlates with poor prognosis and late-stage disease. In vitro, L1CAM enhances proliferation, cell migration, adhesion and chemoresistance. We tested L1CAM and interleukin-1 beta (IL-1β) expression in tumor samples and ascitic fluid from ovarian carcinoma patients to examine its role as a prognostic marker.PATIENTS AND METHODS: We investigated tumor samples and ascitic fluid from 232 serous ovarian carcinoma patients for L1CAM by enzyme-linked immunosorbent assay. L1CAM expression was correlated with pathoclinical parameters and patients' outcome. IL-1β levels were measured in tumor cell lysates. Ovarian cancer cell lines were analyzed for the contribution of L1CAM to IL-1β production and nuclear factor 'kappa-light-chain-enhancer' of activated B-cells (NF-κB) activation.RESULTS: We observed that L1CAM-expressing tumors show a highly invasive phenotype associated with restricted tumor resectability at primary debulking surgery and increased lymphogenic spread. Soluble L1CAM proved to be a marker for poor progression-free survival and chemoresistance. In ovarian carcinoma cell lines, the specific knock-down of L1CAM reduces IL-1β expression and NF-κB activity.CONCLUSIONS: L1CAM expression contributes to the invasive and metastatic phenotype of serous ovarian carcinoma. L1CAM expression and shedding in the tumor microenvironment could contribute to enhanced invasion and tumor progression through increased IL-1β production and NF-κB activation.

AB - BACKGROUND: Overexpression of L1-cell adhesion molecule (L1CAM) has been observed for various carcinomas and correlates with poor prognosis and late-stage disease. In vitro, L1CAM enhances proliferation, cell migration, adhesion and chemoresistance. We tested L1CAM and interleukin-1 beta (IL-1β) expression in tumor samples and ascitic fluid from ovarian carcinoma patients to examine its role as a prognostic marker.PATIENTS AND METHODS: We investigated tumor samples and ascitic fluid from 232 serous ovarian carcinoma patients for L1CAM by enzyme-linked immunosorbent assay. L1CAM expression was correlated with pathoclinical parameters and patients' outcome. IL-1β levels were measured in tumor cell lysates. Ovarian cancer cell lines were analyzed for the contribution of L1CAM to IL-1β production and nuclear factor 'kappa-light-chain-enhancer' of activated B-cells (NF-κB) activation.RESULTS: We observed that L1CAM-expressing tumors show a highly invasive phenotype associated with restricted tumor resectability at primary debulking surgery and increased lymphogenic spread. Soluble L1CAM proved to be a marker for poor progression-free survival and chemoresistance. In ovarian carcinoma cell lines, the specific knock-down of L1CAM reduces IL-1β expression and NF-κB activity.CONCLUSIONS: L1CAM expression contributes to the invasive and metastatic phenotype of serous ovarian carcinoma. L1CAM expression and shedding in the tumor microenvironment could contribute to enhanced invasion and tumor progression through increased IL-1β production and NF-κB activation.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Ascitic Fluid

KW - Carcinoma

KW - Cell Line, Tumor

KW - Disease-Free Survival

KW - Female

KW - Humans

KW - Interleukin-1beta

KW - Kaplan-Meier Estimate

KW - Lymphatic Metastasis

KW - Middle Aged

KW - Multivariate Analysis

KW - NF-kappa B

KW - Neoplasm Invasiveness

KW - Neural Cell Adhesion Molecule L1

KW - Ovarian Neoplasms

KW - Phenotype

KW - Prognosis

KW - Young Adult

U2 - 10.1093/annonc/mdr568

DO - 10.1093/annonc/mdr568

M3 - SCORING: Journal article

C2 - 22228447

VL - 23

SP - 1795

EP - 1802

JO - ANN ONCOL

JF - ANN ONCOL

SN - 0923-7534

IS - 7

ER -