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Prognostic relevance of postoperative platelet count in upper tract urothelial carcinoma after radical nephroureterectomy

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Prognostic relevance of postoperative platelet count in upper tract urothelial carcinoma after radical nephroureterectomy. / Gakis, Georgios; Fritsche, Hans-Martin; Hassan, Fahmy; Kluth, Luis; Miller, Florian; Soave, Armin; Otto, Wolfgang; Schwentner, Christian; Todenhöfer, Tilman; Dahlem, Roland; Burger, Maximillian; Fisch, Margit; Stenzl, Arnulf; Aziz, Atiqullah; Rink, Michael.

In: EUR J CANCER, Vol. 50, No. 15, 01.10.2014, p. 2583-2591.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gakis, G, Fritsche, H-M, Hassan, F, Kluth, L, Miller, F, Soave, A, Otto, W, Schwentner, C, Todenhöfer, T, Dahlem, R, Burger, M, Fisch, M, Stenzl, A, Aziz, A & Rink, M 2014, 'Prognostic relevance of postoperative platelet count in upper tract urothelial carcinoma after radical nephroureterectomy', EUR J CANCER, vol. 50, no. 15, pp. 2583-2591. https://doi.org/10.1016/j.ejca.2014.07.003

APA

Gakis, G., Fritsche, H-M., Hassan, F., Kluth, L., Miller, F., Soave, A., Otto, W., Schwentner, C., Todenhöfer, T., Dahlem, R., Burger, M., Fisch, M., Stenzl, A., Aziz, A., & Rink, M. (2014). Prognostic relevance of postoperative platelet count in upper tract urothelial carcinoma after radical nephroureterectomy. EUR J CANCER, 50(15), 2583-2591. https://doi.org/10.1016/j.ejca.2014.07.003

Vancouver

Gakis G, Fritsche H-M, Hassan F, Kluth L, Miller F, Soave A et al. Prognostic relevance of postoperative platelet count in upper tract urothelial carcinoma after radical nephroureterectomy. EUR J CANCER. 2014 Oct 1;50(15):2583-2591. https://doi.org/10.1016/j.ejca.2014.07.003

Bibtex

@article{a24ac18aacbd4d0ab6b5f3471ed76e8a,
title = "Prognostic relevance of postoperative platelet count in upper tract urothelial carcinoma after radical nephroureterectomy",
abstract = "AIM OF THE STUDY: To assess the impact of perioperative platelet count (PLT) kinetics on recurrence-free survival (RFS) after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC).METHODS: From three prospectively maintained databases of three tertiary care centres a total of 269 patients undergoing RNU without perioperative treatment between 1996 and 2011 were considered for this analysis. Pre- and postoperatively elevated PLT count was defined as >400×10(9)/L. PLT levels were measured 1-3 days preoperatively and 7-10 days postoperatively. The median follow-up was 24 months (Interquartile range (IQR): 10-52). A new weighted scoring model was developed to predict recurrence after RNU based on significant parameters of multivariable analysis.RESULTS: The 5-year RFS in patients with preoperatively normal and elevated PLT count was 58.3% and 29.3%, respectively (p<0.001). The 5-year-RFS was 57.6% in patients with normal postoperative PLT count and 29.7% in those with elevated PLT levels (p<0.001). In multivariable analysis, pT-stage, lymphovascular invasion, ureteral margin status and postoperative thrombocytosis remained independent predictors for RFS. The 5-year RFS in patients with a score of 0 (low-risk), 1 (intermediate-risk) and 2-4 (high-risk) was 77.7%, 47.5% and 12.3%, respectively (p<0.001). Consideration of the variable postoperative thrombocytosis in the final model increased its predictive accuracy by 1.9% with a concordance index of 0.758 (p=0.015).CONCLUSION: PLT kinetics is significantly associated with RFS after RNU for UTUC. We constructed a simple, PLT-based prognostic model for recurrence after RNU.",
keywords = "Aged, Carcinoma, Transitional Cell, Databases, Factual, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Multivariate Analysis, Nephrectomy, Outcome Assessment (Health Care), Platelet Count, Postoperative Period, Prognosis, Proportional Hazards Models, Tertiary Care Centers, Ureter, Urinary Tract, Urologic Neoplasms",
author = "Georgios Gakis and Hans-Martin Fritsche and Fahmy Hassan and Luis Kluth and Florian Miller and Armin Soave and Wolfgang Otto and Christian Schwentner and Tilman Todenh{\"o}fer and Roland Dahlem and Maximillian Burger and Margit Fisch and Arnulf Stenzl and Atiqullah Aziz and Michael Rink",
note = "Copyright {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",
year = "2014",
month = oct,
day = "1",
doi = "10.1016/j.ejca.2014.07.003",
language = "English",
volume = "50",
pages = "2583--2591",
journal = "EUR J CANCER",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "15",

}

RIS

TY - JOUR

T1 - Prognostic relevance of postoperative platelet count in upper tract urothelial carcinoma after radical nephroureterectomy

AU - Gakis, Georgios

AU - Fritsche, Hans-Martin

AU - Hassan, Fahmy

AU - Kluth, Luis

AU - Miller, Florian

AU - Soave, Armin

AU - Otto, Wolfgang

AU - Schwentner, Christian

AU - Todenhöfer, Tilman

AU - Dahlem, Roland

AU - Burger, Maximillian

AU - Fisch, Margit

AU - Stenzl, Arnulf

AU - Aziz, Atiqullah

AU - Rink, Michael

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - AIM OF THE STUDY: To assess the impact of perioperative platelet count (PLT) kinetics on recurrence-free survival (RFS) after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC).METHODS: From three prospectively maintained databases of three tertiary care centres a total of 269 patients undergoing RNU without perioperative treatment between 1996 and 2011 were considered for this analysis. Pre- and postoperatively elevated PLT count was defined as >400×10(9)/L. PLT levels were measured 1-3 days preoperatively and 7-10 days postoperatively. The median follow-up was 24 months (Interquartile range (IQR): 10-52). A new weighted scoring model was developed to predict recurrence after RNU based on significant parameters of multivariable analysis.RESULTS: The 5-year RFS in patients with preoperatively normal and elevated PLT count was 58.3% and 29.3%, respectively (p<0.001). The 5-year-RFS was 57.6% in patients with normal postoperative PLT count and 29.7% in those with elevated PLT levels (p<0.001). In multivariable analysis, pT-stage, lymphovascular invasion, ureteral margin status and postoperative thrombocytosis remained independent predictors for RFS. The 5-year RFS in patients with a score of 0 (low-risk), 1 (intermediate-risk) and 2-4 (high-risk) was 77.7%, 47.5% and 12.3%, respectively (p<0.001). Consideration of the variable postoperative thrombocytosis in the final model increased its predictive accuracy by 1.9% with a concordance index of 0.758 (p=0.015).CONCLUSION: PLT kinetics is significantly associated with RFS after RNU for UTUC. We constructed a simple, PLT-based prognostic model for recurrence after RNU.

AB - AIM OF THE STUDY: To assess the impact of perioperative platelet count (PLT) kinetics on recurrence-free survival (RFS) after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC).METHODS: From three prospectively maintained databases of three tertiary care centres a total of 269 patients undergoing RNU without perioperative treatment between 1996 and 2011 were considered for this analysis. Pre- and postoperatively elevated PLT count was defined as >400×10(9)/L. PLT levels were measured 1-3 days preoperatively and 7-10 days postoperatively. The median follow-up was 24 months (Interquartile range (IQR): 10-52). A new weighted scoring model was developed to predict recurrence after RNU based on significant parameters of multivariable analysis.RESULTS: The 5-year RFS in patients with preoperatively normal and elevated PLT count was 58.3% and 29.3%, respectively (p<0.001). The 5-year-RFS was 57.6% in patients with normal postoperative PLT count and 29.7% in those with elevated PLT levels (p<0.001). In multivariable analysis, pT-stage, lymphovascular invasion, ureteral margin status and postoperative thrombocytosis remained independent predictors for RFS. The 5-year RFS in patients with a score of 0 (low-risk), 1 (intermediate-risk) and 2-4 (high-risk) was 77.7%, 47.5% and 12.3%, respectively (p<0.001). Consideration of the variable postoperative thrombocytosis in the final model increased its predictive accuracy by 1.9% with a concordance index of 0.758 (p=0.015).CONCLUSION: PLT kinetics is significantly associated with RFS after RNU for UTUC. We constructed a simple, PLT-based prognostic model for recurrence after RNU.

KW - Aged

KW - Carcinoma, Transitional Cell

KW - Databases, Factual

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Nephrectomy

KW - Outcome Assessment (Health Care)

KW - Platelet Count

KW - Postoperative Period

KW - Prognosis

KW - Proportional Hazards Models

KW - Tertiary Care Centers

KW - Ureter

KW - Urinary Tract

KW - Urologic Neoplasms

U2 - 10.1016/j.ejca.2014.07.003

DO - 10.1016/j.ejca.2014.07.003

M3 - SCORING: Journal article

C2 - 25088206

VL - 50

SP - 2583

EP - 2591

JO - EUR J CANCER

JF - EUR J CANCER

SN - 0959-8049

IS - 15

ER -