Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study.
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Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study. / Kocher, Thomas; Zheng, Min; Bolli, Martin; Simon, Ronald; Forster, Thomas; Schultz-Thater, Elke; Remmel, Eugenia; Noppen, Christoph; Schmid, Ulrico; Ackermann, Daniel; Mihatsch, Michael J; Gasser, Thomas; Heberer, Michael; Sauter, Guido; Spagnoli, Giulio C.
In: INT J CANCER, Vol. 100, No. 6, 6, 2002, p. 702-705.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study.
AU - Kocher, Thomas
AU - Zheng, Min
AU - Bolli, Martin
AU - Simon, Ronald
AU - Forster, Thomas
AU - Schultz-Thater, Elke
AU - Remmel, Eugenia
AU - Noppen, Christoph
AU - Schmid, Ulrico
AU - Ackermann, Daniel
AU - Mihatsch, Michael J
AU - Gasser, Thomas
AU - Heberer, Michael
AU - Sauter, Guido
AU - Spagnoli, Giulio C
PY - 2002
Y1 - 2002
N2 - TAAs of the MAGE family are mostly studied as targets of specific immune responses. Their potential relevance as tumor markers has also been underlined. We used a MAb, 57B, recognizing MAGE-A4 protein in paraffin-embedded sections, to evaluate its expression in bladder cancers by employing TMA including 2,317 samples from 1,849 patients. In 2,090/2,317 cases (90.2%), immunostaining yielded interpretable results. Since for some patients more than 1 sample was available, only interpretable first biopsies (n = 1,628) were considered. MAGE-A4 protein was expressed at significantly (p <0.001) higher frequency in squamous (25/55, 45.5%) than in adeno (4/15, 26.7%), sarcomatoid (4/14, 28.6%), small cell (5/20, 25%) or transitional cell (281/1,522, 18.5%) carcinomas. In TCCs, overall MAGE-A4 positivity was significantly correlated with invasive phenotype (p <0.001) and high tumor grade (p <0.0001). Clinical data from 908 TCC patients were retrospectively evaluated, revealing that strong 57B staining was highly significantly associated with decreased tumor-specific survival (p <0.0001). These data suggest that evaluation of MAGE-A4 protein expression is useful in the identification of groups of TCCs characterized by severe prognosis, thus possibly providing indications for early MAGE TAA-targeted immunotherapy.
AB - TAAs of the MAGE family are mostly studied as targets of specific immune responses. Their potential relevance as tumor markers has also been underlined. We used a MAb, 57B, recognizing MAGE-A4 protein in paraffin-embedded sections, to evaluate its expression in bladder cancers by employing TMA including 2,317 samples from 1,849 patients. In 2,090/2,317 cases (90.2%), immunostaining yielded interpretable results. Since for some patients more than 1 sample was available, only interpretable first biopsies (n = 1,628) were considered. MAGE-A4 protein was expressed at significantly (p <0.001) higher frequency in squamous (25/55, 45.5%) than in adeno (4/15, 26.7%), sarcomatoid (4/14, 28.6%), small cell (5/20, 25%) or transitional cell (281/1,522, 18.5%) carcinomas. In TCCs, overall MAGE-A4 positivity was significantly correlated with invasive phenotype (p <0.001) and high tumor grade (p <0.0001). Clinical data from 908 TCC patients were retrospectively evaluated, revealing that strong 57B staining was highly significantly associated with decreased tumor-specific survival (p <0.0001). These data suggest that evaluation of MAGE-A4 protein expression is useful in the identification of groups of TCCs characterized by severe prognosis, thus possibly providing indications for early MAGE TAA-targeted immunotherapy.
M3 - SCORING: Zeitschriftenaufsatz
VL - 100
SP - 702
EP - 705
JO - INT J CANCER
JF - INT J CANCER
SN - 0020-7136
IS - 6
M1 - 6
ER -
