Prognostic implications of netrin-1 expression and its receptors in patients with adenocarcinoma of the pancreas.
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Prognostic implications of netrin-1 expression and its receptors in patients with adenocarcinoma of the pancreas. / Link, Björn-Chr.; Reichelt, Uta; Schreiber, Matthias; Kaifi, Jussuf; Wachowiak, Robin; Bogoevski, Dean; Bubenheim, Michael; Cataldegirmen, Güllü; Gawad, Karim A.; Issa, Rana; Koops, Susan; Izbicki, Jakob R.; Yekebas, Emre F.
In: ANN SURG ONCOL, Vol. 14, No. 9, 9, 2007, p. 2591-2599.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Prognostic implications of netrin-1 expression and its receptors in patients with adenocarcinoma of the pancreas.
AU - Link, Björn-Chr.
AU - Reichelt, Uta
AU - Schreiber, Matthias
AU - Kaifi, Jussuf
AU - Wachowiak, Robin
AU - Bogoevski, Dean
AU - Bubenheim, Michael
AU - Cataldegirmen, Güllü
AU - Gawad, Karim A.
AU - Issa, Rana
AU - Koops, Susan
AU - Izbicki, Jakob R.
AU - Yekebas, Emre F.
PY - 2007
Y1 - 2007
N2 - BACKGROUND: To assess the interaction between the expression of netrin-1 or of its receptors to the prognosis of ductal adenocarcinoma of the pancreas. METHODS: In 82 patients with resectable pancreatic adenocarcinoma who underwent curative operation, the expression patterns of netrin-1, deleted in colorectal carcinomas (DCC), UNC5H3, and neogenin were determined by immunohistochemical staining. Kaplan-Meier analysis was performed to assess the prognostic relevance of the examined expression patterns. RESULTS: Median follow-up was 15 +/- 19.9 months (range, 4-108 months). Patients suffering from tumors with no or little expression of netrin-1 (n = 67) had a median recurrence-free survival of 10 months (95% CI, 7-13 months), while a middle to strong expression (n = 15) was associated with a significantly worse median recurrence-free survival of only four months (95% CI, three to five months, p = 0.0165). Overall and recurrence-free survival showed no significant differences between the different expression patterns of DCC, UNC5H3 or neogenin. Netrin-1 expression had significant impact (p = 0.001) on overall survival of patients suffering from poorly differentiated tumors. Stratification according to the nodal status revealed significant influence (p = 0.007) of UNC5H3 expression on the overall survival of patients with pN1 status. CONCLUSION: Expression of netrin-1 has significant impact on time to tumor relapse in adenocarcinoma of the pancreas. Netrin-1 expression is associated with worse outcome in poorly differentiated pancreatic adenocarcinomas. Risk-stratification according to the UNC5H3 receptor expression pattern shows that node positive patients (pN1) with no to little UNC5H3 expression carry a significantly worse prognosis than those with middle to strong UNC5H3 expression.
AB - BACKGROUND: To assess the interaction between the expression of netrin-1 or of its receptors to the prognosis of ductal adenocarcinoma of the pancreas. METHODS: In 82 patients with resectable pancreatic adenocarcinoma who underwent curative operation, the expression patterns of netrin-1, deleted in colorectal carcinomas (DCC), UNC5H3, and neogenin were determined by immunohistochemical staining. Kaplan-Meier analysis was performed to assess the prognostic relevance of the examined expression patterns. RESULTS: Median follow-up was 15 +/- 19.9 months (range, 4-108 months). Patients suffering from tumors with no or little expression of netrin-1 (n = 67) had a median recurrence-free survival of 10 months (95% CI, 7-13 months), while a middle to strong expression (n = 15) was associated with a significantly worse median recurrence-free survival of only four months (95% CI, three to five months, p = 0.0165). Overall and recurrence-free survival showed no significant differences between the different expression patterns of DCC, UNC5H3 or neogenin. Netrin-1 expression had significant impact (p = 0.001) on overall survival of patients suffering from poorly differentiated tumors. Stratification according to the nodal status revealed significant influence (p = 0.007) of UNC5H3 expression on the overall survival of patients with pN1 status. CONCLUSION: Expression of netrin-1 has significant impact on time to tumor relapse in adenocarcinoma of the pancreas. Netrin-1 expression is associated with worse outcome in poorly differentiated pancreatic adenocarcinomas. Risk-stratification according to the UNC5H3 receptor expression pattern shows that node positive patients (pN1) with no to little UNC5H3 expression carry a significantly worse prognosis than those with middle to strong UNC5H3 expression.
M3 - SCORING: Zeitschriftenaufsatz
VL - 14
SP - 2591
EP - 2599
JO - ANN SURG ONCOL
JF - ANN SURG ONCOL
SN - 1068-9265
IS - 9
M1 - 9
ER -
