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Prognostic Impact of Prolonged Cross-Clamp Time in Coronary Artery Bypass Grafting

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Prognostic Impact of Prolonged Cross-Clamp Time in Coronary Artery Bypass Grafting. / Ruggieri, Vito G; Bounader, Karl; Verhoye, Jean Philippe; Onorati, Francesco; Rubino, Antonino S; Gatti, Giuseppe; Tauriainen, Tuomas; De Feo, Marisa; Reichart, Daniel; Dalén, Magnus; Svenarud, Peter; Faggian, Giuseppe; Santarpino, Giuseppe; Maselli, Daniele; Gherli, Riccardo; Mariscalco, Giovanni; Salsano, Antonio; Nicolini, Francesco; Gherli, Tiziano; Saccocci, Matteo; Airaksinen, Juhani K E; Chocron, Sidney; Perrotti, Andrea; Biancari, Fausto.

In: HEART LUNG CIRC, Vol. 27, No. 12, 12.2018, p. 1476-1482.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ruggieri, VG, Bounader, K, Verhoye, JP, Onorati, F, Rubino, AS, Gatti, G, Tauriainen, T, De Feo, M, Reichart, D, Dalén, M, Svenarud, P, Faggian, G, Santarpino, G, Maselli, D, Gherli, R, Mariscalco, G, Salsano, A, Nicolini, F, Gherli, T, Saccocci, M, Airaksinen, JKE, Chocron, S, Perrotti, A & Biancari, F 2018, 'Prognostic Impact of Prolonged Cross-Clamp Time in Coronary Artery Bypass Grafting', HEART LUNG CIRC, vol. 27, no. 12, pp. 1476-1482. https://doi.org/10.1016/j.hlc.2017.09.006

APA

Ruggieri, V. G., Bounader, K., Verhoye, J. P., Onorati, F., Rubino, A. S., Gatti, G., Tauriainen, T., De Feo, M., Reichart, D., Dalén, M., Svenarud, P., Faggian, G., Santarpino, G., Maselli, D., Gherli, R., Mariscalco, G., Salsano, A., Nicolini, F., Gherli, T., ... Biancari, F. (2018). Prognostic Impact of Prolonged Cross-Clamp Time in Coronary Artery Bypass Grafting. HEART LUNG CIRC, 27(12), 1476-1482. https://doi.org/10.1016/j.hlc.2017.09.006

Vancouver

Ruggieri VG, Bounader K, Verhoye JP, Onorati F, Rubino AS, Gatti G et al. Prognostic Impact of Prolonged Cross-Clamp Time in Coronary Artery Bypass Grafting. HEART LUNG CIRC. 2018 Dec;27(12):1476-1482. https://doi.org/10.1016/j.hlc.2017.09.006

Bibtex

@article{249ae59963ce4632a0d701392bc7ecfa,
title = "Prognostic Impact of Prolonged Cross-Clamp Time in Coronary Artery Bypass Grafting",
abstract = "BACKGROUND: The prognostic impact of cross-clamp time (XCT) in patients undergoing isolated coronary artery bypass grafting (CABG) has not been thoroughly investigated.MATERIAL AND METHODS: 2957 patients who underwent on-pump isolated CABG from the prospective multicentre E-CABG study were the subjects of this analysis.RESULTS: The mean XCT in this series was 58±25minutes Cross-clamp time was >60 minutes in 1134 patients (38.3%), >75minutes in 619 patients (20.9%) and >90minutes in 296 patients (10.0%). Multivariate analysis showed that XCT was an independent predictor of 30-day mortality (p<0.0001, OR 1.027, 95%CI 1.015-1.039) along with age (p<0.0001), female gender (p=0.001), pulmonary disease (p=0.001), poor mobility (p=0.002), urgency status (p=0.007), critical preoperative status (p=0.002) and participating centres (p=0.015). Adjusted risk of 30-day mortality was highest for XCT >75minutes (2.9% vs. 1.7%, p=0.002, OR 3.479, 95%CI 1.609-7.520). Analysis of 428 propensity score matched pairs showed that XCT >75minutes was associated with significantly increased risk of early mortality, prolonged use of inotropes, postoperative use of intra-aortic balloon pump, use of extracorporeal membrane oxygenation, atrial fibrillation, prolonged stay in the intensive care unit and of composite major adverse events.CONCLUSIONS: Isolated CABG is currently performed with prolonged XCT in a significant number of patients and this seems to be a determinant of poor early outcome.",
keywords = "Aged, Coronary Artery Bypass/methods, Europe/epidemiology, Female, Follow-Up Studies, Hospital Mortality/trends, Humans, Incidence, Male, Myocardial Ischemia/surgery, Postoperative Complications/epidemiology, Prognosis, Propensity Score, Prospective Studies, Risk Factors, Survival Rate/trends, Time Factors, Treatment Outcome",
author = "Ruggieri, {Vito G} and Karl Bounader and Verhoye, {Jean Philippe} and Francesco Onorati and Rubino, {Antonino S} and Giuseppe Gatti and Tuomas Tauriainen and {De Feo}, Marisa and Daniel Reichart and Magnus Dal{\'e}n and Peter Svenarud and Giuseppe Faggian and Giuseppe Santarpino and Daniele Maselli and Riccardo Gherli and Giovanni Mariscalco and Antonio Salsano and Francesco Nicolini and Tiziano Gherli and Matteo Saccocci and Airaksinen, {Juhani K E} and Sidney Chocron and Andrea Perrotti and Fausto Biancari",
note = "Copyright {\textcopyright} 2017 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.",
year = "2018",
month = dec,
doi = "10.1016/j.hlc.2017.09.006",
language = "English",
volume = "27",
pages = "1476--1482",
journal = "HEART LUNG CIRC",
issn = "1443-9506",
publisher = "Elsevier Limited",
number = "12",

}

RIS

TY - JOUR

T1 - Prognostic Impact of Prolonged Cross-Clamp Time in Coronary Artery Bypass Grafting

AU - Ruggieri, Vito G

AU - Bounader, Karl

AU - Verhoye, Jean Philippe

AU - Onorati, Francesco

AU - Rubino, Antonino S

AU - Gatti, Giuseppe

AU - Tauriainen, Tuomas

AU - De Feo, Marisa

AU - Reichart, Daniel

AU - Dalén, Magnus

AU - Svenarud, Peter

AU - Faggian, Giuseppe

AU - Santarpino, Giuseppe

AU - Maselli, Daniele

AU - Gherli, Riccardo

AU - Mariscalco, Giovanni

AU - Salsano, Antonio

AU - Nicolini, Francesco

AU - Gherli, Tiziano

AU - Saccocci, Matteo

AU - Airaksinen, Juhani K E

AU - Chocron, Sidney

AU - Perrotti, Andrea

AU - Biancari, Fausto

N1 - Copyright © 2017 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.

PY - 2018/12

Y1 - 2018/12

N2 - BACKGROUND: The prognostic impact of cross-clamp time (XCT) in patients undergoing isolated coronary artery bypass grafting (CABG) has not been thoroughly investigated.MATERIAL AND METHODS: 2957 patients who underwent on-pump isolated CABG from the prospective multicentre E-CABG study were the subjects of this analysis.RESULTS: The mean XCT in this series was 58±25minutes Cross-clamp time was >60 minutes in 1134 patients (38.3%), >75minutes in 619 patients (20.9%) and >90minutes in 296 patients (10.0%). Multivariate analysis showed that XCT was an independent predictor of 30-day mortality (p<0.0001, OR 1.027, 95%CI 1.015-1.039) along with age (p<0.0001), female gender (p=0.001), pulmonary disease (p=0.001), poor mobility (p=0.002), urgency status (p=0.007), critical preoperative status (p=0.002) and participating centres (p=0.015). Adjusted risk of 30-day mortality was highest for XCT >75minutes (2.9% vs. 1.7%, p=0.002, OR 3.479, 95%CI 1.609-7.520). Analysis of 428 propensity score matched pairs showed that XCT >75minutes was associated with significantly increased risk of early mortality, prolonged use of inotropes, postoperative use of intra-aortic balloon pump, use of extracorporeal membrane oxygenation, atrial fibrillation, prolonged stay in the intensive care unit and of composite major adverse events.CONCLUSIONS: Isolated CABG is currently performed with prolonged XCT in a significant number of patients and this seems to be a determinant of poor early outcome.

AB - BACKGROUND: The prognostic impact of cross-clamp time (XCT) in patients undergoing isolated coronary artery bypass grafting (CABG) has not been thoroughly investigated.MATERIAL AND METHODS: 2957 patients who underwent on-pump isolated CABG from the prospective multicentre E-CABG study were the subjects of this analysis.RESULTS: The mean XCT in this series was 58±25minutes Cross-clamp time was >60 minutes in 1134 patients (38.3%), >75minutes in 619 patients (20.9%) and >90minutes in 296 patients (10.0%). Multivariate analysis showed that XCT was an independent predictor of 30-day mortality (p<0.0001, OR 1.027, 95%CI 1.015-1.039) along with age (p<0.0001), female gender (p=0.001), pulmonary disease (p=0.001), poor mobility (p=0.002), urgency status (p=0.007), critical preoperative status (p=0.002) and participating centres (p=0.015). Adjusted risk of 30-day mortality was highest for XCT >75minutes (2.9% vs. 1.7%, p=0.002, OR 3.479, 95%CI 1.609-7.520). Analysis of 428 propensity score matched pairs showed that XCT >75minutes was associated with significantly increased risk of early mortality, prolonged use of inotropes, postoperative use of intra-aortic balloon pump, use of extracorporeal membrane oxygenation, atrial fibrillation, prolonged stay in the intensive care unit and of composite major adverse events.CONCLUSIONS: Isolated CABG is currently performed with prolonged XCT in a significant number of patients and this seems to be a determinant of poor early outcome.

KW - Aged

KW - Coronary Artery Bypass/methods

KW - Europe/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Hospital Mortality/trends

KW - Humans

KW - Incidence

KW - Male

KW - Myocardial Ischemia/surgery

KW - Postoperative Complications/epidemiology

KW - Prognosis

KW - Propensity Score

KW - Prospective Studies

KW - Risk Factors

KW - Survival Rate/trends

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1016/j.hlc.2017.09.006

DO - 10.1016/j.hlc.2017.09.006

M3 - SCORING: Journal article

C2 - 29276146

VL - 27

SP - 1476

EP - 1482

JO - HEART LUNG CIRC

JF - HEART LUNG CIRC

SN - 1443-9506

IS - 12

ER -