Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols.
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Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. / Bielack, Stefan S; Kempf-Bielack, Beate; Delling, Günter; Exner, G Ulrich; Flege, Silke; Helmke, Knut; Kotz, Rainer; Salzer-Kuntschik, Mechthild; Werner, Matthias; Winkelmann, Winfried; Zoubek, Andreas; Jürgens, Heribert; Winkler, Kurt.
In: J CLIN ONCOL, Vol. 20, No. 3, 3, 2002, p. 776-790.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols.
AU - Bielack, Stefan S
AU - Kempf-Bielack, Beate
AU - Delling, Günter
AU - Exner, G Ulrich
AU - Flege, Silke
AU - Helmke, Knut
AU - Kotz, Rainer
AU - Salzer-Kuntschik, Mechthild
AU - Werner, Matthias
AU - Winkelmann, Winfried
AU - Zoubek, Andreas
AU - Jürgens, Heribert
AU - Winkler, Kurt
PY - 2002
Y1 - 2002
N2 - PURPOSE: To define prognostic factors for response and long-term outcome for a wide spectrum of osteosarcomas, extending well beyond those of the typical young patient with seemingly localized extremity disease. PATIENTS AND METHODS: A total of 1,702 consecutive newly diagnosed patients with high-grade osteosarcoma of the trunk or limbs registered into the neoadjuvant studies of the Cooperative Osteosarcoma Study Group before July 1998 were entered into an analysis of demographic, tumor-related, and treatment-related variables, response, and survival. The intended therapeutic strategy included preoperative and postoperative chemotherapy with multiple agents as well as surgery of all operable lesions. RESULTS: Axial tumor site, male sex, and a long history of symptoms were associated with poor response to chemotherapy in univariate and multivariate analysis. Actuarial 10-year overall and event-free survival rates were 59.8% and 48.9%. Among the variables assessable at diagnosis, patient age (actuarial 10-year survival > or = 40, 41.6%; <40, 60.2%; P =.012), tumor site (axial, 29.2%; limb, 61.7%; P or = one third, 52.5%; <one third, 66.7%; P
AB - PURPOSE: To define prognostic factors for response and long-term outcome for a wide spectrum of osteosarcomas, extending well beyond those of the typical young patient with seemingly localized extremity disease. PATIENTS AND METHODS: A total of 1,702 consecutive newly diagnosed patients with high-grade osteosarcoma of the trunk or limbs registered into the neoadjuvant studies of the Cooperative Osteosarcoma Study Group before July 1998 were entered into an analysis of demographic, tumor-related, and treatment-related variables, response, and survival. The intended therapeutic strategy included preoperative and postoperative chemotherapy with multiple agents as well as surgery of all operable lesions. RESULTS: Axial tumor site, male sex, and a long history of symptoms were associated with poor response to chemotherapy in univariate and multivariate analysis. Actuarial 10-year overall and event-free survival rates were 59.8% and 48.9%. Among the variables assessable at diagnosis, patient age (actuarial 10-year survival > or = 40, 41.6%; <40, 60.2%; P =.012), tumor site (axial, 29.2%; limb, 61.7%; P or = one third, 52.5%; <one third, 66.7%; P
M3 - SCORING: Zeitschriftenaufsatz
VL - 20
SP - 776
EP - 790
JO - J CLIN ONCOL
JF - J CLIN ONCOL
SN - 0732-183X
IS - 3
M1 - 3
ER -
