Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma
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Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma. / Gakis, Georgios; Morgan, Todd M; Efstathiou, Jason A; Keegan, Kirk A; Mischinger, Johannes; Todenhoefer, Tilman; Schubert, Tina; Zaid, Harras B; Hrbacek, Jan; Ali-El-Dein, Bedeir; Clayman, Rebecca H; Galland, Sigolene; Olugbade, Kola; Rink, Michael; Fritsche, Hans-Martin; Burger, Maximilian; Chang, Sam S; Babjuk, Marko; Thalmann, George N; Stenzl, Arnulf; Daneshmand, Siamak.
In: WORLD J UROL, Vol. 34, No. 1, 01.2016, p. 97-103.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma
AU - Gakis, Georgios
AU - Morgan, Todd M
AU - Efstathiou, Jason A
AU - Keegan, Kirk A
AU - Mischinger, Johannes
AU - Todenhoefer, Tilman
AU - Schubert, Tina
AU - Zaid, Harras B
AU - Hrbacek, Jan
AU - Ali-El-Dein, Bedeir
AU - Clayman, Rebecca H
AU - Galland, Sigolene
AU - Olugbade, Kola
AU - Rink, Michael
AU - Fritsche, Hans-Martin
AU - Burger, Maximilian
AU - Chang, Sam S
AU - Babjuk, Marko
AU - Thalmann, George N
AU - Stenzl, Arnulf
AU - Daneshmand, Siamak
PY - 2016/1
Y1 - 2016/1
N2 - PURPOSE: To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC).METHODS: A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death.RESULTS: Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026).CONCLUSIONS: These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
AB - PURPOSE: To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC).METHODS: A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death.RESULTS: Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026).CONCLUSIONS: These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
U2 - 10.1007/s00345-015-1583-7
DO - 10.1007/s00345-015-1583-7
M3 - SCORING: Journal article
C2 - 25981402
VL - 34
SP - 97
EP - 103
JO - WORLD J UROL
JF - WORLD J UROL
SN - 0724-4983
IS - 1
ER -