Prognostic Factors After Definitive Radio(Chemo)Therapy of Locally Advanced Head and Neck Cancer
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Prognostic Factors After Definitive Radio(Chemo)Therapy of Locally Advanced Head and Neck Cancer. / Seidl, Daniel; Janssen, Stefan; Strojan, Primoz; Bajrovic, Amira; Schild, Steven E; Rades, Dirk.
In: ANTICANCER RES, Vol. 36, No. 5, 05.2016, p. 2523-6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Prognostic Factors After Definitive Radio(Chemo)Therapy of Locally Advanced Head and Neck Cancer
AU - Seidl, Daniel
AU - Janssen, Stefan
AU - Strojan, Primoz
AU - Bajrovic, Amira
AU - Schild, Steven E
AU - Rades, Dirk
N1 - Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
PY - 2016/5
Y1 - 2016/5
N2 - AIM: To identify predictors of locoregional control (LRC) and overall survival (OS) after definitive radio(chemo)therapy for squamous cell carcinoma of the head and neck (SCCHN).PATIENTS AND METHODS: Two hundred and seventy-five patients were evaluated; 261 patients received radiochemotherapy with 30-40 mg/m(2) of cisplatin weekly, three courses of cisplatin 100 mg/m(2), two courses of cisplatin 5x20 mg/m(2) or two courses of cisplatin 5×20 mg/m(2)plus 5-fluorouracil. Ten characteristics were analyzed: Pre-radiotherapy hemoglobin, T-/N-category, Karnofsky performance-score (KPS), gender, age, chemotherapy type, tumor site, grading and radiation dose.RESULTS: On multivariate analyses, hemoglobin 12-14 g/dl (p=0.040), lower T-category (p=0.010), lower N-category (p=0.042) and female gender (p=0.006) were predictive of LRC. Hemoglobin >12 g/dl (p=0.020), lower N-category (p<0.001), KPS ≥80 (p<0.001), female gender (p=0.024) and cisplatin 100 mg/m(2) or 5×20 mg/m(2) (p<0.001) were predictors of improved OS.CONCLUSION: Predictors of LRC and OS were identified that can improve personalization of treatment. Since chemotherapy type was associated with OS, studies comparing different regimens are warranted.
AB - AIM: To identify predictors of locoregional control (LRC) and overall survival (OS) after definitive radio(chemo)therapy for squamous cell carcinoma of the head and neck (SCCHN).PATIENTS AND METHODS: Two hundred and seventy-five patients were evaluated; 261 patients received radiochemotherapy with 30-40 mg/m(2) of cisplatin weekly, three courses of cisplatin 100 mg/m(2), two courses of cisplatin 5x20 mg/m(2) or two courses of cisplatin 5×20 mg/m(2)plus 5-fluorouracil. Ten characteristics were analyzed: Pre-radiotherapy hemoglobin, T-/N-category, Karnofsky performance-score (KPS), gender, age, chemotherapy type, tumor site, grading and radiation dose.RESULTS: On multivariate analyses, hemoglobin 12-14 g/dl (p=0.040), lower T-category (p=0.010), lower N-category (p=0.042) and female gender (p=0.006) were predictive of LRC. Hemoglobin >12 g/dl (p=0.020), lower N-category (p<0.001), KPS ≥80 (p<0.001), female gender (p=0.024) and cisplatin 100 mg/m(2) or 5×20 mg/m(2) (p<0.001) were predictors of improved OS.CONCLUSION: Predictors of LRC and OS were identified that can improve personalization of treatment. Since chemotherapy type was associated with OS, studies comparing different regimens are warranted.
KW - Antineoplastic Combined Chemotherapy Protocols
KW - Carcinoma, Squamous Cell
KW - Chemoradiotherapy
KW - Cisplatin
KW - Female
KW - Fluorouracil
KW - Head and Neck Neoplasms
KW - Humans
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Survival Rate
KW - Journal Article
M3 - SCORING: Journal article
C2 - 27127167
VL - 36
SP - 2523
EP - 2526
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 5
ER -
