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Prognosis of early pre‑discharge and late left ventricular dilatation by cardiac magnetic resonance imaging after acute myocardial infarction

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Prognosis of early pre‑discharge and late left ventricular dilatation by cardiac magnetic resonance imaging after acute myocardial infarction. / Sinn, Martin; Lund, Gunnar; Muellerleile, Kai; Bibiza-Freiwald, Eric; Saeed, Maythem; Avanesov, Maxim; Lenz, Alexander; Starekova, Jitka; Kodolitsch, Yskert; Blankenberg, Stefan; Adam, Gerhard; Tahir, Enver.

In: INT J CARDIOVAS IMAG, Vol. 37, No. 5, 05.2021, p. 1711–1720.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sinn, M, Lund, G, Muellerleile, K, Bibiza-Freiwald, E, Saeed, M, Avanesov, M, Lenz, A, Starekova, J, Kodolitsch, Y, Blankenberg, S, Adam, G & Tahir, E 2021, 'Prognosis of early pre‑discharge and late left ventricular dilatation by cardiac magnetic resonance imaging after acute myocardial infarction', INT J CARDIOVAS IMAG, vol. 37, no. 5, pp. 1711–1720. https://doi.org/10.1007/s10554-020-02136-5

APA

Sinn, M., Lund, G., Muellerleile, K., Bibiza-Freiwald, E., Saeed, M., Avanesov, M., Lenz, A., Starekova, J., Kodolitsch, Y., Blankenberg, S., Adam, G., & Tahir, E. (2021). Prognosis of early pre‑discharge and late left ventricular dilatation by cardiac magnetic resonance imaging after acute myocardial infarction. INT J CARDIOVAS IMAG, 37(5), 1711–1720. https://doi.org/10.1007/s10554-020-02136-5

Vancouver

Sinn M, Lund G, Muellerleile K, Bibiza-Freiwald E, Saeed M, Avanesov M et al. Prognosis of early pre‑discharge and late left ventricular dilatation by cardiac magnetic resonance imaging after acute myocardial infarction. INT J CARDIOVAS IMAG. 2021 May;37(5):1711–1720. https://doi.org/10.1007/s10554-020-02136-5

Bibtex

@article{03bfd1b7d0f44e5ea4b5c4e257965a41,
title = "Prognosis of early pre‑discharge and late left ventricular dilatation by cardiac magnetic resonance imaging after acute myocardial infarction",
abstract = "To study the long-term prognosis of early pre-discharge and late left ventricular (LV) dilatation in patients with first ST-elevation myocardial infarction (STEMI) treated by percutaneous coronary intervention (PCI) and contemporary medical therapy. Long-term follow-up > 15 years was available in 53 consecutive patients (55 ± 13 years) with first STEMI. Late gadolinium enhanced (LGE) cardiac magnetic resonance imaging (CMR) was obtained at baseline 5 ± 3 days and follow-up 8 ± 3 months after STEMI to measure LV function, volumes and infarct size. Early pre-discharge dilatation was defined as increased left ventricular end-diastolic volume index (LVEDVi) at baseline CMR with > 97 ml/m2 for males and > 90 ml/m2 for females. Late dilatation was defined as initially normal LVEDVi, which increased ≥ 20% at follow-up. Early dilatation was present in 7 patients (13%), whereas late dilatation occurred in 11 patients (21%). Patients with early LV dilatation had highest mortality (57%), whereas patients with late dilatation had similar mortality (27%) compared to patients without dilatation (26%). Multivariate Cox analysis showed that age (P < 0.001), ejection fraction at baseline (P < 0.01) and early dilatation (P < 0.01) were independent predictors of death. Early dilatation qualified as an exclusive independent predictor of long-term mortality after adjustment for age and ejection fraction (P < 0.05, hazard ratio: 2.2, 95% confidence interval: 1.2 to 7.9). Early pre-discharge LV dilatation by CMR enabled strong long-term risk stratification after STEMI. The high mortality of early LV dilatation underscores the clinical importance of this post-infarction complication, which occurred despite PCI and contemporary medical therapy.",
author = "Martin Sinn and Gunnar Lund and Kai Muellerleile and Eric Bibiza-Freiwald and Maythem Saeed and Maxim Avanesov and Alexander Lenz and Jitka Starekova and Yskert Kodolitsch and Stefan Blankenberg and Gerhard Adam and Enver Tahir",
year = "2021",
month = may,
doi = "10.1007/s10554-020-02136-5",
language = "English",
volume = "37",
pages = "1711–1720",
journal = "INT J CARDIOVAS IMAG",
issn = "1569-5794",
publisher = "Springer Netherlands",
number = "5",

}

RIS

TY - JOUR

T1 - Prognosis of early pre‑discharge and late left ventricular dilatation by cardiac magnetic resonance imaging after acute myocardial infarction

AU - Sinn, Martin

AU - Lund, Gunnar

AU - Muellerleile, Kai

AU - Bibiza-Freiwald, Eric

AU - Saeed, Maythem

AU - Avanesov, Maxim

AU - Lenz, Alexander

AU - Starekova, Jitka

AU - Kodolitsch, Yskert

AU - Blankenberg, Stefan

AU - Adam, Gerhard

AU - Tahir, Enver

PY - 2021/5

Y1 - 2021/5

N2 - To study the long-term prognosis of early pre-discharge and late left ventricular (LV) dilatation in patients with first ST-elevation myocardial infarction (STEMI) treated by percutaneous coronary intervention (PCI) and contemporary medical therapy. Long-term follow-up > 15 years was available in 53 consecutive patients (55 ± 13 years) with first STEMI. Late gadolinium enhanced (LGE) cardiac magnetic resonance imaging (CMR) was obtained at baseline 5 ± 3 days and follow-up 8 ± 3 months after STEMI to measure LV function, volumes and infarct size. Early pre-discharge dilatation was defined as increased left ventricular end-diastolic volume index (LVEDVi) at baseline CMR with > 97 ml/m2 for males and > 90 ml/m2 for females. Late dilatation was defined as initially normal LVEDVi, which increased ≥ 20% at follow-up. Early dilatation was present in 7 patients (13%), whereas late dilatation occurred in 11 patients (21%). Patients with early LV dilatation had highest mortality (57%), whereas patients with late dilatation had similar mortality (27%) compared to patients without dilatation (26%). Multivariate Cox analysis showed that age (P < 0.001), ejection fraction at baseline (P < 0.01) and early dilatation (P < 0.01) were independent predictors of death. Early dilatation qualified as an exclusive independent predictor of long-term mortality after adjustment for age and ejection fraction (P < 0.05, hazard ratio: 2.2, 95% confidence interval: 1.2 to 7.9). Early pre-discharge LV dilatation by CMR enabled strong long-term risk stratification after STEMI. The high mortality of early LV dilatation underscores the clinical importance of this post-infarction complication, which occurred despite PCI and contemporary medical therapy.

AB - To study the long-term prognosis of early pre-discharge and late left ventricular (LV) dilatation in patients with first ST-elevation myocardial infarction (STEMI) treated by percutaneous coronary intervention (PCI) and contemporary medical therapy. Long-term follow-up > 15 years was available in 53 consecutive patients (55 ± 13 years) with first STEMI. Late gadolinium enhanced (LGE) cardiac magnetic resonance imaging (CMR) was obtained at baseline 5 ± 3 days and follow-up 8 ± 3 months after STEMI to measure LV function, volumes and infarct size. Early pre-discharge dilatation was defined as increased left ventricular end-diastolic volume index (LVEDVi) at baseline CMR with > 97 ml/m2 for males and > 90 ml/m2 for females. Late dilatation was defined as initially normal LVEDVi, which increased ≥ 20% at follow-up. Early dilatation was present in 7 patients (13%), whereas late dilatation occurred in 11 patients (21%). Patients with early LV dilatation had highest mortality (57%), whereas patients with late dilatation had similar mortality (27%) compared to patients without dilatation (26%). Multivariate Cox analysis showed that age (P < 0.001), ejection fraction at baseline (P < 0.01) and early dilatation (P < 0.01) were independent predictors of death. Early dilatation qualified as an exclusive independent predictor of long-term mortality after adjustment for age and ejection fraction (P < 0.05, hazard ratio: 2.2, 95% confidence interval: 1.2 to 7.9). Early pre-discharge LV dilatation by CMR enabled strong long-term risk stratification after STEMI. The high mortality of early LV dilatation underscores the clinical importance of this post-infarction complication, which occurred despite PCI and contemporary medical therapy.

U2 - 10.1007/s10554-020-02136-5

DO - 10.1007/s10554-020-02136-5

M3 - SCORING: Journal article

VL - 37

SP - 1711

EP - 1720

JO - INT J CARDIOVAS IMAG

JF - INT J CARDIOVAS IMAG

SN - 1569-5794

IS - 5

ER -