Primary Focal Dystonia: Evidence for Distinct Neuropsychiatric and Personality Profiles.
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Primary Focal Dystonia: Evidence for Distinct Neuropsychiatric and Personality Profiles. / Lencer, Rebekka; Steinlechner, Susanne; Stahlberg, Jessica; Rehling, Hilka; Orth, Michael; Bäumer, Tobias; Rumpf, Hans-Juergen; Meyer, Christian; Klein, Christine; Muenchau, Alexander; Hagenah, Johann.
In: J NEUROL NEUROSUR PS, 2009.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Primary Focal Dystonia: Evidence for Distinct Neuropsychiatric and Personality Profiles.
AU - Lencer, Rebekka
AU - Steinlechner, Susanne
AU - Stahlberg, Jessica
AU - Rehling, Hilka
AU - Orth, Michael
AU - Bäumer, Tobias
AU - Rumpf, Hans-Juergen
AU - Meyer, Christian
AU - Klein, Christine
AU - Muenchau, Alexander
AU - Hagenah, Johann
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Primary focal dystonia (PFD) is characterized by motor symptoms. Frequent co-occurrence of abnormal mental conditions has been mentioned for decades but is less well defined. We evaluated prevalence rates of psychiatric disorders, personality disorders and traits in a large cohort of PFD patients. METHODS: Prevalence rates of clinical psychiatric diagnoses in 86 PFD patients were compared to a population-based sample (N=3943) using a multiple regression approach. Furthermore, participants were evaluated for personality disorders with the Five Factor Personality Inventory. RESULTS: Lifetime prevalence for any psychiatric or personality disorder was 70.9%. More specifically, axis I disorders occurred at a 4.5-fold increased chance. Highest odds ratios were found for social phobia (OR 21.6), agoraphobia (OR 16.7) and panic disorder (OR 11.5). We further found an increased prevalence rate of 32.6% for anxious personality disorders comprising obsessive-compulsive (22.1%) and avoidant personality disorders (16.3%). Except for social phobia, psychiatric disorders manifested prior to the occurrence of dystonia symptoms. In the self-rating of personality traits, PFD patients demonstrated pronounced agreeableness, conscientiousness, and reduced openness. CONCLUSIONS: Patients with PFD show distinct neuropsychiatric and personality profiles of the anxiety spectrum. PFD should therefore be viewed as a neuropsychiatric disorder rather than a pure movement disorder.
AB - BACKGROUND: Primary focal dystonia (PFD) is characterized by motor symptoms. Frequent co-occurrence of abnormal mental conditions has been mentioned for decades but is less well defined. We evaluated prevalence rates of psychiatric disorders, personality disorders and traits in a large cohort of PFD patients. METHODS: Prevalence rates of clinical psychiatric diagnoses in 86 PFD patients were compared to a population-based sample (N=3943) using a multiple regression approach. Furthermore, participants were evaluated for personality disorders with the Five Factor Personality Inventory. RESULTS: Lifetime prevalence for any psychiatric or personality disorder was 70.9%. More specifically, axis I disorders occurred at a 4.5-fold increased chance. Highest odds ratios were found for social phobia (OR 21.6), agoraphobia (OR 16.7) and panic disorder (OR 11.5). We further found an increased prevalence rate of 32.6% for anxious personality disorders comprising obsessive-compulsive (22.1%) and avoidant personality disorders (16.3%). Except for social phobia, psychiatric disorders manifested prior to the occurrence of dystonia symptoms. In the self-rating of personality traits, PFD patients demonstrated pronounced agreeableness, conscientiousness, and reduced openness. CONCLUSIONS: Patients with PFD show distinct neuropsychiatric and personality profiles of the anxiety spectrum. PFD should therefore be viewed as a neuropsychiatric disorder rather than a pure movement disorder.
M3 - SCORING: Zeitschriftenaufsatz
JO - J NEUROL NEUROSUR PS
JF - J NEUROL NEUROSUR PS
SN - 0022-3050
ER -