Prevalence of non-alcoholic fatty liver disease in four different weight related patient Groups: association with small bowel length and risk factors
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Prevalence of non-alcoholic fatty liver disease in four different weight related patient Groups: association with small bowel length and risk factors. / Hillenbrand, Andreas; Kiebler, Brigitte; Schwab, Cornelia; Scheja, Ludger; Xu, Pengfei; Henne-Bruns, Doris; Wolf, Anna Maria; Knippschild, Uwe.
In: BMC RES NOTES, Vol. 8, 03.07.2015, p. 290.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Prevalence of non-alcoholic fatty liver disease in four different weight related patient Groups: association with small bowel length and risk factors
AU - Hillenbrand, Andreas
AU - Kiebler, Brigitte
AU - Schwab, Cornelia
AU - Scheja, Ludger
AU - Xu, Pengfei
AU - Henne-Bruns, Doris
AU - Wolf, Anna Maria
AU - Knippschild, Uwe
PY - 2015/7/3
Y1 - 2015/7/3
N2 - BACKGROUND: Non-alcoholic steatohepatitis (NASH) is an obesity associated common cause of liver inflammation and there are concerns that it may turn out to be the most common cause of liver failure as prevalence of obesity increases. We determined the prevalence of NASH in relation to gender and body mass index (BMI). Furthermore, we assessed the association of NASH with the length of the small bowel.METHODS: 124 liver samples obtained during routine operations were examined looking for NAFLD Activity Score (nonalcoholic fatty liver disease). The length of small bowel was measured intraoperatively. For evaluation, patients were divided into four groups according to their BMI (group 1: normal weight, group 2: overweight, group 3: grade I/II morbidly obese, and group 4 grade III morbidly obese patients).RESULTS: BMI showed a strong positive correlation with risk of NASH and a weak positive correlation with small bowel length. No normal weight patient was at risk of NASH, whereas in group 2 14% had uncertain and 32% definite NASH. In group 3 11% had uncertain and 27% definite NASH. In group 4 nearly two-thirds were classified as uncertain or definite NASH. Median length of small bowel in all patients was 450 cm (range 226-860 cm). Within group 4, patients with definite/uncertain NASH had a longer small bowel than patients without NASH.CONCLUSIONS: Prevalence of NASH is high in morbidly obese. Small bowel length could influence the complex etiology of the disease.
AB - BACKGROUND: Non-alcoholic steatohepatitis (NASH) is an obesity associated common cause of liver inflammation and there are concerns that it may turn out to be the most common cause of liver failure as prevalence of obesity increases. We determined the prevalence of NASH in relation to gender and body mass index (BMI). Furthermore, we assessed the association of NASH with the length of the small bowel.METHODS: 124 liver samples obtained during routine operations were examined looking for NAFLD Activity Score (nonalcoholic fatty liver disease). The length of small bowel was measured intraoperatively. For evaluation, patients were divided into four groups according to their BMI (group 1: normal weight, group 2: overweight, group 3: grade I/II morbidly obese, and group 4 grade III morbidly obese patients).RESULTS: BMI showed a strong positive correlation with risk of NASH and a weak positive correlation with small bowel length. No normal weight patient was at risk of NASH, whereas in group 2 14% had uncertain and 32% definite NASH. In group 3 11% had uncertain and 27% definite NASH. In group 4 nearly two-thirds were classified as uncertain or definite NASH. Median length of small bowel in all patients was 450 cm (range 226-860 cm). Within group 4, patients with definite/uncertain NASH had a longer small bowel than patients without NASH.CONCLUSIONS: Prevalence of NASH is high in morbidly obese. Small bowel length could influence the complex etiology of the disease.
U2 - 10.1186/s13104-015-1224-7
DO - 10.1186/s13104-015-1224-7
M3 - SCORING: Journal article
C2 - 26138508
VL - 8
SP - 290
JO - BMC RES NOTES
JF - BMC RES NOTES
SN - 1756-0500
ER -