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Prevalence and pattern of focal and potential diffuse myocardial fibrosis in male and female marathon runners using contrast-enhanced cardiac magnetic resonance

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Prevalence and pattern of focal and potential diffuse myocardial fibrosis in male and female marathon runners using contrast-enhanced cardiac magnetic resonance. / Ragab, Haissam; Lund, Gunnar K; Breitsprecher, Lynn; Sinn, Martin R; Muellerleile, Kai; Cavus, Ersin; Stehning, Christian; Tahir, Enver; Blankenberg, Stefan; Patten, Monica; Pressler, Axel; Adam, Gerhard; Avanesov, Maxim.

In: EUR RADIOL, Vol. 33, No. 7, 07.2023, p. 4648-4656.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ragab, H, Lund, GK, Breitsprecher, L, Sinn, MR, Muellerleile, K, Cavus, E, Stehning, C, Tahir, E, Blankenberg, S, Patten, M, Pressler, A, Adam, G & Avanesov, M 2023, 'Prevalence and pattern of focal and potential diffuse myocardial fibrosis in male and female marathon runners using contrast-enhanced cardiac magnetic resonance', EUR RADIOL, vol. 33, no. 7, pp. 4648-4656. https://doi.org/10.1007/s00330-023-09416-3

APA

Ragab, H., Lund, G. K., Breitsprecher, L., Sinn, M. R., Muellerleile, K., Cavus, E., Stehning, C., Tahir, E., Blankenberg, S., Patten, M., Pressler, A., Adam, G., & Avanesov, M. (2023). Prevalence and pattern of focal and potential diffuse myocardial fibrosis in male and female marathon runners using contrast-enhanced cardiac magnetic resonance. EUR RADIOL, 33(7), 4648-4656. https://doi.org/10.1007/s00330-023-09416-3

Vancouver

Ragab H, Lund GK, Breitsprecher L, Sinn MR, Muellerleile K, Cavus E et al. Prevalence and pattern of focal and potential diffuse myocardial fibrosis in male and female marathon runners using contrast-enhanced cardiac magnetic resonance. EUR RADIOL. 2023 Jul;33(7):4648-4656. https://doi.org/10.1007/s00330-023-09416-3

Bibtex

@article{d584504027b4464296854953f2c6a433,
title = "Prevalence and pattern of focal and potential diffuse myocardial fibrosis in male and female marathon runners using contrast-enhanced cardiac magnetic resonance",
abstract = "OBJECTIVES: This study analyzed the prevalence and pattern of focal and potential diffuse myocardial fibrosis detected by late gadolinium enhancement (LGE) and extracellular volume (ECV) imaging in male and female marathon runners using cardiac magnetic resonance (CMR).METHODS: Seventy-four marathon runners were studied including 55 males (44 ± 8 years) and 19 females (36 ± 7 years) and compared to 36 controls with similar age and sex using contrast-enhanced CMR, exercise testing, and blood samples.RESULTS: Contrast-enhanced CMR revealed focal myocardial fibrosis in 8 of 74 runners (11%). The majority of runners were male (7 of 8, 88%). LGE was typically non-ischemic in 7 of 8 runners (88%) and ischemic in one runner. ECV was higher in remote myocardium without LGE in male runners (25.5 ± 2.3%) compared to male controls (24.0 ± 3.0%, p < 0.05), indicating the potential presence of diffuse myocardial fibrosis. LV mass was higher in LGE + males (86 ± 18 g/m2) compared to LGE- males (73 ± 14 g/m2, p < 0.05). Furthermore, LGE + males had lower weight (69 ± 9 vs 77 ± 9 kg, p < 0.05) and shorter best marathon finishing times (3.2 ± 0.3 h) compared to LGE- males (3.6 ± 0.4 h, p < 0.05) suggesting higher training load in these runners to accomplish the marathon in a short time.CONCLUSION: The high frequency of non-ischemic myocardial fibrosis in LGE + male runners can be related to increased LV mass in these runners. Furthermore, a higher training load could explain the higher LV mass and could be one additional cofactor in the genesis of myocardial fibrosis in marathon runners.KEY POINTS: • A high frequency of myocardial fibrosis was found in marathon runners. • Myocardial fibrosis occurred typically in male runners and was typically non-ischemic. • Higher training load could be one cofactor in the genesis of myocardial fibrosis in marathon runners.",
author = "Haissam Ragab and Lund, {Gunnar K} and Lynn Breitsprecher and Sinn, {Martin R} and Kai Muellerleile and Ersin Cavus and Christian Stehning and Enver Tahir and Stefan Blankenberg and Monica Patten and Axel Pressler and Gerhard Adam and Maxim Avanesov",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = jul,
doi = "10.1007/s00330-023-09416-3",
language = "English",
volume = "33",
pages = "4648--4656",
journal = "EUR RADIOL",
issn = "0938-7994",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Prevalence and pattern of focal and potential diffuse myocardial fibrosis in male and female marathon runners using contrast-enhanced cardiac magnetic resonance

AU - Ragab, Haissam

AU - Lund, Gunnar K

AU - Breitsprecher, Lynn

AU - Sinn, Martin R

AU - Muellerleile, Kai

AU - Cavus, Ersin

AU - Stehning, Christian

AU - Tahir, Enver

AU - Blankenberg, Stefan

AU - Patten, Monica

AU - Pressler, Axel

AU - Adam, Gerhard

AU - Avanesov, Maxim

N1 - © 2023. The Author(s).

PY - 2023/7

Y1 - 2023/7

N2 - OBJECTIVES: This study analyzed the prevalence and pattern of focal and potential diffuse myocardial fibrosis detected by late gadolinium enhancement (LGE) and extracellular volume (ECV) imaging in male and female marathon runners using cardiac magnetic resonance (CMR).METHODS: Seventy-four marathon runners were studied including 55 males (44 ± 8 years) and 19 females (36 ± 7 years) and compared to 36 controls with similar age and sex using contrast-enhanced CMR, exercise testing, and blood samples.RESULTS: Contrast-enhanced CMR revealed focal myocardial fibrosis in 8 of 74 runners (11%). The majority of runners were male (7 of 8, 88%). LGE was typically non-ischemic in 7 of 8 runners (88%) and ischemic in one runner. ECV was higher in remote myocardium without LGE in male runners (25.5 ± 2.3%) compared to male controls (24.0 ± 3.0%, p < 0.05), indicating the potential presence of diffuse myocardial fibrosis. LV mass was higher in LGE + males (86 ± 18 g/m2) compared to LGE- males (73 ± 14 g/m2, p < 0.05). Furthermore, LGE + males had lower weight (69 ± 9 vs 77 ± 9 kg, p < 0.05) and shorter best marathon finishing times (3.2 ± 0.3 h) compared to LGE- males (3.6 ± 0.4 h, p < 0.05) suggesting higher training load in these runners to accomplish the marathon in a short time.CONCLUSION: The high frequency of non-ischemic myocardial fibrosis in LGE + male runners can be related to increased LV mass in these runners. Furthermore, a higher training load could explain the higher LV mass and could be one additional cofactor in the genesis of myocardial fibrosis in marathon runners.KEY POINTS: • A high frequency of myocardial fibrosis was found in marathon runners. • Myocardial fibrosis occurred typically in male runners and was typically non-ischemic. • Higher training load could be one cofactor in the genesis of myocardial fibrosis in marathon runners.

AB - OBJECTIVES: This study analyzed the prevalence and pattern of focal and potential diffuse myocardial fibrosis detected by late gadolinium enhancement (LGE) and extracellular volume (ECV) imaging in male and female marathon runners using cardiac magnetic resonance (CMR).METHODS: Seventy-four marathon runners were studied including 55 males (44 ± 8 years) and 19 females (36 ± 7 years) and compared to 36 controls with similar age and sex using contrast-enhanced CMR, exercise testing, and blood samples.RESULTS: Contrast-enhanced CMR revealed focal myocardial fibrosis in 8 of 74 runners (11%). The majority of runners were male (7 of 8, 88%). LGE was typically non-ischemic in 7 of 8 runners (88%) and ischemic in one runner. ECV was higher in remote myocardium without LGE in male runners (25.5 ± 2.3%) compared to male controls (24.0 ± 3.0%, p < 0.05), indicating the potential presence of diffuse myocardial fibrosis. LV mass was higher in LGE + males (86 ± 18 g/m2) compared to LGE- males (73 ± 14 g/m2, p < 0.05). Furthermore, LGE + males had lower weight (69 ± 9 vs 77 ± 9 kg, p < 0.05) and shorter best marathon finishing times (3.2 ± 0.3 h) compared to LGE- males (3.6 ± 0.4 h, p < 0.05) suggesting higher training load in these runners to accomplish the marathon in a short time.CONCLUSION: The high frequency of non-ischemic myocardial fibrosis in LGE + male runners can be related to increased LV mass in these runners. Furthermore, a higher training load could explain the higher LV mass and could be one additional cofactor in the genesis of myocardial fibrosis in marathon runners.KEY POINTS: • A high frequency of myocardial fibrosis was found in marathon runners. • Myocardial fibrosis occurred typically in male runners and was typically non-ischemic. • Higher training load could be one cofactor in the genesis of myocardial fibrosis in marathon runners.

U2 - 10.1007/s00330-023-09416-3

DO - 10.1007/s00330-023-09416-3

M3 - SCORING: Journal article

C2 - 36683089

VL - 33

SP - 4648

EP - 4656

JO - EUR RADIOL

JF - EUR RADIOL

SN - 0938-7994

IS - 7

ER -