Pretrichodermamides D-F from a Marine Algicolous Fungus Penicillium sp. KMM 4672
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Pretrichodermamides D-F from a Marine Algicolous Fungus Penicillium sp. KMM 4672. / Yurchenko, Anton N; Smetanina, Olga F; Ivanets, Elena V; Kalinovsky, Anatoly I; Khudyakova, Yuliya V; Kirichuk, Natalya N; Popov, Roman S; Bokemeyer, Carsten; von Amsberg, Gunhild; Chingizova, Ekaterina A; Afiyatullov, Shamil Sh; Dyshlovoy, Sergey A.
In: MAR DRUGS, Vol. 14, No. 7, 27.06.2016, p. E122.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Pretrichodermamides D-F from a Marine Algicolous Fungus Penicillium sp. KMM 4672
AU - Yurchenko, Anton N
AU - Smetanina, Olga F
AU - Ivanets, Elena V
AU - Kalinovsky, Anatoly I
AU - Khudyakova, Yuliya V
AU - Kirichuk, Natalya N
AU - Popov, Roman S
AU - Bokemeyer, Carsten
AU - von Amsberg, Gunhild
AU - Chingizova, Ekaterina A
AU - Afiyatullov, Shamil Sh
AU - Dyshlovoy, Sergey A
PY - 2016/6/27
Y1 - 2016/6/27
N2 - Three new epidithiodiketopiperazines pretrichodermamides D-F (1-3), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 1-5 were determined based on spectroscopic methods. The absolute configuration of pretrichodermamide D (1) was established by a combination of modified Mosher's method, NOESY data, and biogenetic considerations. N-Methylpretrichodermamide B (5) showed strong cytotoxicity against 22Rv1 human prostate cancer cells resistant to androgen receptor targeted therapies.
AB - Three new epidithiodiketopiperazines pretrichodermamides D-F (1-3), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 1-5 were determined based on spectroscopic methods. The absolute configuration of pretrichodermamide D (1) was established by a combination of modified Mosher's method, NOESY data, and biogenetic considerations. N-Methylpretrichodermamide B (5) showed strong cytotoxicity against 22Rv1 human prostate cancer cells resistant to androgen receptor targeted therapies.
KW - Journal Article
U2 - 10.3390/md14070122
DO - 10.3390/md14070122
M3 - SCORING: Journal article
C2 - 27355960
VL - 14
SP - E122
JO - MAR DRUGS
JF - MAR DRUGS
SN - 1660-3397
IS - 7
ER -