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Preterm prelabor rupture of membranes and outcome of very-low-birth-weight infants in the German Neonatal Network

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Preterm prelabor rupture of membranes and outcome of very-low-birth-weight infants in the German Neonatal Network. / Hanke, Kathrin; Hartz, Annika; Manz, Maike; Bendiks, Meike; Heitmann, Friedhelm; Orlikowsky, Thorsten; Müller, Andreas; Olbertz, Dirk; Kühn, Thomas; Siegel, Jens; von der Wense, Axel; Wieg, Christian; Kribs, Angela; Stein, Anja; Pagel, Julia; Herting, Egbert; Göpel, Wolfgang; Härtel, Christoph; German Neonatal Network (GNN).

In: PLOS ONE, Vol. 10, No. 4, 2015, p. e0122564.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hanke, K, Hartz, A, Manz, M, Bendiks, M, Heitmann, F, Orlikowsky, T, Müller, A, Olbertz, D, Kühn, T, Siegel, J, von der Wense, A, Wieg, C, Kribs, A, Stein, A, Pagel, J, Herting, E, Göpel, W, Härtel, C & German Neonatal Network (GNN) 2015, 'Preterm prelabor rupture of membranes and outcome of very-low-birth-weight infants in the German Neonatal Network', PLOS ONE, vol. 10, no. 4, pp. e0122564. https://doi.org/10.1371/journal.pone.0122564

APA

Hanke, K., Hartz, A., Manz, M., Bendiks, M., Heitmann, F., Orlikowsky, T., Müller, A., Olbertz, D., Kühn, T., Siegel, J., von der Wense, A., Wieg, C., Kribs, A., Stein, A., Pagel, J., Herting, E., Göpel, W., Härtel, C., & German Neonatal Network (GNN) (2015). Preterm prelabor rupture of membranes and outcome of very-low-birth-weight infants in the German Neonatal Network. PLOS ONE, 10(4), e0122564. https://doi.org/10.1371/journal.pone.0122564

Vancouver

Hanke K, Hartz A, Manz M, Bendiks M, Heitmann F, Orlikowsky T et al. Preterm prelabor rupture of membranes and outcome of very-low-birth-weight infants in the German Neonatal Network. PLOS ONE. 2015;10(4):e0122564. https://doi.org/10.1371/journal.pone.0122564

Bibtex

@article{9a1666de713442109a78827c03343363,
title = "Preterm prelabor rupture of membranes and outcome of very-low-birth-weight infants in the German Neonatal Network",
abstract = "OBJECTIVE: It was the aim of our study to evaluate the independent effect of preterm prelabor rupture of membranes (PPROM) as a cause of preterm delivery on mortality during primary hospital stay and significant morbidities in very-low-birth-weight (VLBW) infants < 32 weeks of gestation.DESIGN: Observational, epidemiological study design.SETTING: Population-based cohort, German Neonatal Network (GNN).POPULATION: 6102 VLBW infants were enrolled in GNN from 2009-2012, n=4120 fulfilled criteria for primary analysis (< 32 gestational weeks, no pre-eclampsia, HELLP (highly elevated liver enzymes and low platelets syndrome) or placental abruption as cause of preterm birth).METHODS: Multivariable logistic regression analyses included PPROM as potential risk factors for adverse outcomes and well established items such as gestational age in weeks, birth weight, antenatal steroids, center, inborn delivery, multiple birth, gender and being small-for-gestational-age.RESULTS: PPROM as cause of preterm delivery had no independent effect on the risk of early-onset sepsis, clinical sepsis and blood-culture proven sepsis, while gestational age proved to be the most important contributor to sepsis risk. The diagnosis of PPROM was associated with an increased risk for bronchopulmonary dysplasia (BPD; OR: 1.25, 95% CI: 1.02-1.55, p=0.03) but not with other major outcomes.CONCLUSIONS: The diagnosis of PPROM per se is not associated with adverse outcome in VLBW infants < 32 weeks apart from a moderately increased risk for BPD. Randomized controlled trials with primary neonatal outcomes are needed to determine which subgroup of VLBW infants benefit from expectant or intentional management of PPROM.",
keywords = "Cohort Studies, Female, Fetal Membranes, Premature Rupture/epidemiology, Germany/epidemiology, Humans, Infant, Newborn, Infant, Very Low Birth Weight/physiology, Logistic Models, Mortality, Pregnancy, Premature Birth/epidemiology",
author = "Kathrin Hanke and Annika Hartz and Maike Manz and Meike Bendiks and Friedhelm Heitmann and Thorsten Orlikowsky and Andreas M{\"u}ller and Dirk Olbertz and Thomas K{\"u}hn and Jens Siegel and {von der Wense}, Axel and Christian Wieg and Angela Kribs and Anja Stein and Julia Pagel and Egbert Herting and Wolfgang G{\"o}pel and Christoph H{\"a}rtel and {German Neonatal Network (GNN)}",
year = "2015",
doi = "10.1371/journal.pone.0122564",
language = "English",
volume = "10",
pages = "e0122564",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - Preterm prelabor rupture of membranes and outcome of very-low-birth-weight infants in the German Neonatal Network

AU - Hanke, Kathrin

AU - Hartz, Annika

AU - Manz, Maike

AU - Bendiks, Meike

AU - Heitmann, Friedhelm

AU - Orlikowsky, Thorsten

AU - Müller, Andreas

AU - Olbertz, Dirk

AU - Kühn, Thomas

AU - Siegel, Jens

AU - von der Wense, Axel

AU - Wieg, Christian

AU - Kribs, Angela

AU - Stein, Anja

AU - Pagel, Julia

AU - Herting, Egbert

AU - Göpel, Wolfgang

AU - Härtel, Christoph

AU - German Neonatal Network (GNN)

PY - 2015

Y1 - 2015

N2 - OBJECTIVE: It was the aim of our study to evaluate the independent effect of preterm prelabor rupture of membranes (PPROM) as a cause of preterm delivery on mortality during primary hospital stay and significant morbidities in very-low-birth-weight (VLBW) infants < 32 weeks of gestation.DESIGN: Observational, epidemiological study design.SETTING: Population-based cohort, German Neonatal Network (GNN).POPULATION: 6102 VLBW infants were enrolled in GNN from 2009-2012, n=4120 fulfilled criteria for primary analysis (< 32 gestational weeks, no pre-eclampsia, HELLP (highly elevated liver enzymes and low platelets syndrome) or placental abruption as cause of preterm birth).METHODS: Multivariable logistic regression analyses included PPROM as potential risk factors for adverse outcomes and well established items such as gestational age in weeks, birth weight, antenatal steroids, center, inborn delivery, multiple birth, gender and being small-for-gestational-age.RESULTS: PPROM as cause of preterm delivery had no independent effect on the risk of early-onset sepsis, clinical sepsis and blood-culture proven sepsis, while gestational age proved to be the most important contributor to sepsis risk. The diagnosis of PPROM was associated with an increased risk for bronchopulmonary dysplasia (BPD; OR: 1.25, 95% CI: 1.02-1.55, p=0.03) but not with other major outcomes.CONCLUSIONS: The diagnosis of PPROM per se is not associated with adverse outcome in VLBW infants < 32 weeks apart from a moderately increased risk for BPD. Randomized controlled trials with primary neonatal outcomes are needed to determine which subgroup of VLBW infants benefit from expectant or intentional management of PPROM.

AB - OBJECTIVE: It was the aim of our study to evaluate the independent effect of preterm prelabor rupture of membranes (PPROM) as a cause of preterm delivery on mortality during primary hospital stay and significant morbidities in very-low-birth-weight (VLBW) infants < 32 weeks of gestation.DESIGN: Observational, epidemiological study design.SETTING: Population-based cohort, German Neonatal Network (GNN).POPULATION: 6102 VLBW infants were enrolled in GNN from 2009-2012, n=4120 fulfilled criteria for primary analysis (< 32 gestational weeks, no pre-eclampsia, HELLP (highly elevated liver enzymes and low platelets syndrome) or placental abruption as cause of preterm birth).METHODS: Multivariable logistic regression analyses included PPROM as potential risk factors for adverse outcomes and well established items such as gestational age in weeks, birth weight, antenatal steroids, center, inborn delivery, multiple birth, gender and being small-for-gestational-age.RESULTS: PPROM as cause of preterm delivery had no independent effect on the risk of early-onset sepsis, clinical sepsis and blood-culture proven sepsis, while gestational age proved to be the most important contributor to sepsis risk. The diagnosis of PPROM was associated with an increased risk for bronchopulmonary dysplasia (BPD; OR: 1.25, 95% CI: 1.02-1.55, p=0.03) but not with other major outcomes.CONCLUSIONS: The diagnosis of PPROM per se is not associated with adverse outcome in VLBW infants < 32 weeks apart from a moderately increased risk for BPD. Randomized controlled trials with primary neonatal outcomes are needed to determine which subgroup of VLBW infants benefit from expectant or intentional management of PPROM.

KW - Cohort Studies

KW - Female

KW - Fetal Membranes, Premature Rupture/epidemiology

KW - Germany/epidemiology

KW - Humans

KW - Infant, Newborn

KW - Infant, Very Low Birth Weight/physiology

KW - Logistic Models

KW - Mortality

KW - Pregnancy

KW - Premature Birth/epidemiology

U2 - 10.1371/journal.pone.0122564

DO - 10.1371/journal.pone.0122564

M3 - SCORING: Journal article

C2 - 25856083

VL - 10

SP - e0122564

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 4

ER -